SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ARG A 147
GLY A  83
GLY A  89
PRO A  99
VAL A 104
 None
NDP  A 301 (-3.5A)
EDO  A 215 (-3.3A)
None
None
 0.98A 1k6cB-3kgyA:
undetectable		 1k6cB-3kgyA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 ILE A 146
ALA A 141
GLY A 142
GLU A 143
HIS A  80
 None
 1.21A 1n6cA-3kgyA:
undetectable		 1n6cA-3kgyA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 8 GLU A  97
PHE A  74
HIS A 101
GLY A 119
 None
 1.13A 2ha4A-3kgyA:
undetectable		 2ha4A-3kgyA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ILE A   8
GLY A 151
LEU A 163
VAL A 164
ILE A 148
 NDP  A 301 (-3.6A)
NDP  A 301 (-3.3A)
EDO  A 216 ( 4.6A)
None
None
 1.24A 3adsB-3kgyA:
undetectable		 3adsB-3kgyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 6 HIS A 206
SER A   9
GLU A 168
ASP A 145
 None
NDP  A 301 (-4.5A)
None
None
 1.41A 4blvA-3kgyA:
undetectable		 4blvA-3kgyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 ILE A 146
ALA A 141
GLY A 142
GLU A 143
HIS A  80
 None
 1.21A 4e47A-3kgyA:
undetectable		 4e47A-3kgyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 ILE A 146
ALA A 141
GLY A 142
GLU A 143
HIS A  80
 None
 1.21A 4e47B-3kgyA:
undetectable		 4e47B-3kgyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 ILE A 146
ALA A 141
GLY A 142
GLU A 143
HIS A  80
 None
 1.20A 4e47C-3kgyA:
undetectable		 4e47C-3kgyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 VAL A 164
GLY A 151
GLY A  83
ILE A 148
ILE A   8
 None
NDP  A 301 (-3.3A)
NDP  A 301 (-3.5A)
None
NDP  A 301 (-3.6A)
 1.00A 4iv0A-3kgyA:
undetectable		 4iv0A-3kgyA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 ILE A 146
ALA A 141
GLY A 142
GLU A 143
HIS A  80
 None
 1.27A 4jdsA-3kgyA:
undetectable		 4jdsA-3kgyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 ILE A 146
ALA A 141
GLY A 142
GLU A 143
HIS A  80
 None
 1.25A 4jdsB-3kgyA:
undetectable		 4jdsB-3kgyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 ILE A 146
ALA A 141
GLY A 142
GLU A 143
HIS A  80
 None
 1.20A 4jdsC-3kgyA:
undetectable		 4jdsC-3kgyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ILE A 146
ALA A 141
GLY A 142
GLU A 143
HIS A  80
 None
 1.19A 4jlgA-3kgyA:
undetectable		 4jlgA-3kgyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 VAL A 164
GLY A 151
GLY A  83
ILE A 148
ILE A   8
 None
NDP  A 301 (-3.3A)
NDP  A 301 (-3.5A)
None
NDP  A 301 (-3.6A)
 1.03A 4mwzB-3kgyA:
undetectable		 4mwzB-3kgyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 5 ARG A 117
ALA A  98
GLY A 119
PRO A 118
 None
 0.87A 4u9uA-3kgyA:
2.5		 4u9uA-3kgyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 5 ARG A 117
ALA A  98
GLY A 119
PRO A 118
 None
 0.96A 4u9uB-3kgyA:
2.4		 4u9uB-3kgyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 ILE A 146
ALA A 141
GLY A 142
GLU A 143
HIS A  80
 None
 1.22A 5ayfA-3kgyA:
undetectable		 5ayfA-3kgyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 6 GLU A  19
GLY A  93
ARG A  92
GLY A  89
 None
None
None
EDO  A 215 (-3.3A)
 0.76A 5cdnA-3kgyA:
undetectable
5cdnB-3kgyA:
undetectable		 5cdnA-3kgyA:
20.30
5cdnB-3kgyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 5 HIS A  80
ILE A 148
ILE A 146
TYR A 158
 None
 1.23A 5dnuA-3kgyA:
undetectable		 5dnuA-3kgyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 5 HIS A  80
ILE A 148
ILE A 146
TYR A 158
 None
 1.26A 5dnvA-3kgyA:
undetectable		 5dnvA-3kgyA:
20.29