SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kh8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici)
5 / 10 THR A 259
PHE A 271
ALA A 273
VAL A  55
ILE A  32
None
0.97A 1claA-3kh8A:
undetectable
1claA-3kh8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici)
4 / 7 LEU A 218
ASP A 194
ILE A  74
GLN A  94
None
1.00A 2qqcG-3kh8A:
undetectable
2qqcJ-3kh8A:
undetectable
2qqcG-3kh8A:
10.65
2qqcJ-3kh8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici)
4 / 7 LEU A 218
ASP A 194
ILE A  74
GLN A  94
None
1.04A 2qqcI-3kh8A:
undetectable
2qqcL-3kh8A:
undetectable
2qqcI-3kh8A:
10.65
2qqcL-3kh8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici)
3 / 3 LYS A 230
ARG A 226
LYS A 276
None
1.20A 3okxA-3kh8A:
undetectable
3okxA-3kh8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici)
4 / 7 PHE A 271
VAL A 245
ILE A 243
SER A 220
None
0.96A 3pglA-3kh8A:
undetectable
3pglA-3kh8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici)
4 / 5 GLU A 264
GLY A 265
TYR A 290
GLN A 292
None
1.24A 3w9tB-3kh8A:
undetectable
3w9tB-3kh8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici)
5 / 11 LEU A  52
VAL A  96
PHE A 271
SER A 225
PHE A 288
None
1.46A 4evrA-3kh8A:
undetectable
4evrA-3kh8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici)
5 / 12 LEU A 143
VAL A  55
PHE A 240
SER A 225
PHE A  50
None
1.45A 4iarA-3kh8A:
undetectable
4iarA-3kh8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici)
5 / 12 PHE A 271
GLY A 222
ALA A 224
ILE A 282
THR A 259
None
1.02A 4xdrA-3kh8A:
undetectable
4xdrA-3kh8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici)
5 / 12 TYR A 155
LEU A 152
ILE A  89
MET A  81
LEU A   9
None
1.43A 5ycpA-3kh8A:
undetectable
5ycpA-3kh8A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici)
3 / 3 ASP A  24
ARG A  23
ASP A  65
None
0.85A 5zvgA-3kh8A:
undetectable
5zvgA-3kh8A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici)
3 / 3 ASP A  24
ARG A  23
ASP A  65
None
0.82A 5zvgB-3kh8A:
undetectable
5zvgB-3kh8A:
23.41