SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3khd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		5 / 12 MET A 285
ASP A 111
LEU A 109
THR A 359
MET A 324
 None
 1.41A 1xoqA-3khdA:
undetectable		 1xoqA-3khdA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		4 / 7 ALA A 242
ASP A 244
GLY A 270
ILE A 272
 None
 0.93A 2fxdB-3khdA:
undetectable		 2fxdB-3khdA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		4 / 8 LEU A 157
SER A 160
LEU A 204
ASP A 210
 None
 0.96A 2j2pA-3khdA:
undetectable
2j2pB-3khdA:
undetectable		 2j2pA-3khdA:
17.75
2j2pB-3khdA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		4 / 7 ASN A 512
GLY A 502
THR A 431
SER A 401
 None
 1.19A 2o5yH-3khdA:
undetectable
2o5yL-3khdA:
undetectable		 2o5yH-3khdA:
18.27
2o5yL-3khdA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		4 / 8 ILE A 396
ASN A 312
TYR A 438
SER A 391
 None
 1.10A 2zw9B-3khdA:
undetectable		 2zw9B-3khdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		3 / 3 THR A 329
LYS A 200
GLU A 326
 None
 1.02A 3ijdB-3khdA:
9.8		 3ijdB-3khdA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		3 / 3 THR A 329
LYS A 264
GLU A 326
 None
 0.97A 3ijdB-3khdA:
9.8		 3ijdB-3khdA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		8 / 10 THR A  53
PRO A  56
ARG A  76
ASN A  78
HIS A  81
GLY A  82
GLY A 357
ALA A 360
 None
 0.52A 3pp7B-3khdA:
56.6		 3pp7B-3khdA:
43.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		4 / 8 PHE A  77
PHE A  91
PHE A 225
ALA A 226
 None
 0.88A 3t3sF-3khdA:
undetectable		 3t3sF-3khdA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		5 / 12 ILE A 284
LEU A 110
ILE A 239
ILE A 248
LEU A 252
 None
 0.99A 3w67B-3khdA:
1.5		 3w67B-3khdA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		3 / 3 GLU A 404
ARG A 408
GLN A 314
 None
 0.78A 4rtbA-3khdA:
2.2		 4rtbA-3khdA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		4 / 6 LEU A 347
ILE A 319
THR A 350
MET A 324
 None
 1.27A 5ljeA-3khdA:
undetectable		 5ljeA-3khdA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 3khd PYRUVATE KINASE
(Plasmodium
falciparum) 		5 / 10 ILE A 214
ILE A 213
THR A 112
ILE A 234
ILE A 261
 None
 0.99A 5murE-3khdA:
undetectable		 5murE-3khdA:
9.35