SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3khe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3khe CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3
(Toxoplasma
gondii) 		4 / 8 PHE A 129
ILE A 140
LEU A 145
LEU A 148
 None
 0.91A 1eupA-3kheA:
undetectable		 1eupA-3kheA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3khe CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3
(Toxoplasma
gondii) 		5 / 12 VAL A  96
SER A  95
SER A  18
LEU A 119
LEU A  42
 None
 1.39A 2zlcA-3kheA:
undetectable		 2zlcA-3kheA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 3khe CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3
(Toxoplasma
gondii) 		4 / 8 PHE A 132
ILE A 140
VAL A 174
MET A 182
 None
 0.50A 4rjdA-3kheA:
9.2		 4rjdA-3kheA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3khe CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3
(Toxoplasma
gondii) 		5 / 9 LEU A  42
GLU A  38
LEU A 118
LEU A 119
ARG A 124
 None
 1.31A 5dxgA-3kheA:
0.0		 5dxgA-3kheA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3khe CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3
(Toxoplasma
gondii) 		5 / 10 LEU A  42
GLU A  38
LEU A 118
LEU A 119
ARG A 124
 None
 1.30A 5hyrA-3kheA:
undetectable		 5hyrA-3kheA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 3khe CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3
(Toxoplasma
gondii) 		4 / 6 TYR A 106
THR A  43
ASP A  50
GLY A  55
 None
None
CA  A 195 ( 3.1A)
None
 0.63A 5mraA-3kheA:
2.0
5mraB-3kheA:
3.3		 5mraA-3kheA:
23.50
5mraB-3kheA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 3khe CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3
(Toxoplasma
gondii) 		5 / 12 ILE A 104
TYR A  66
GLY A   7
ALA A   8
LEU A  42
 None
 1.23A 5zwrA-3kheA:
undetectable		 5zwrA-3kheA:
19.60