SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3khk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		3 / 3 TRP A 103
VAL A 104
PRO A 105
 None
 0.75A 1rg1A-3khkA:
1.9		 1rg1A-3khkA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		3 / 3 TRP A 103
VAL A 104
PRO A 105
 None
 0.75A 1rh0A-3khkA:
1.8		 1rh0A-3khkA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ASP A 482
LEU A 486
GLN A 503
PHE A 506
ILE A 462
 None
 1.36A 1xosA-3khkA:
undetectable		 1xosA-3khkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 THR A 228
GLY A 253
SER A 254
GLY A 256
ASP A 317
 None
 0.75A 2b25B-3khkA:
10.3		 2b25B-3khkA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ARG A 516
TYR A 527
PHE A 520
GLY A 407
LEU A 381
 None
 1.43A 2nyrB-3khkA:
2.4		 2nyrB-3khkA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		6 / 12 ALA A 251
GLY A 253
GLY A 256
SER A 318
ASN A 335
PRO A 337
 None
 0.67A 2okcA-3khkA:
29.9		 2okcA-3khkA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		6 / 12 TYR A 226
ALA A 251
GLY A 253
GLY A 256
SER A 318
ASN A 335
 None
 0.67A 2okcA-3khkA:
29.9		 2okcA-3khkA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		6 / 12 ALA A 251
GLY A 253
GLY A 256
SER A 318
ASN A 335
PRO A 337
 None
 0.69A 2okcB-3khkA:
29.4		 2okcB-3khkA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ILE A 236
ALA A 251
SER A 318
ASN A 335
PRO A 337
 None
 1.20A 2okcB-3khkA:
29.4		 2okcB-3khkA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		6 / 12 TYR A 226
ALA A 251
GLY A 253
GLY A 256
SER A 318
ASN A 335
 None
 0.73A 2okcB-3khkA:
29.4		 2okcB-3khkA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ASN A 335
LEU A 392
VAL A 423
LEU A 425
THR A 431
 None
 1.32A 2q7kA-3khkA:
undetectable		 2q7kA-3khkA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		4 / 5 LEU A 425
PRO A 426
LEU A 429
ILE A 232
 None
 0.85A 2qd4A-3khkA:
undetectable		 2qd4A-3khkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		6 / 12 THR A 228
ALA A 251
GLY A 253
GLY A 256
ASN A 335
PRO A 337
 None
 0.78A 2y7hB-3khkA:
25.3		 2y7hB-3khkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 THR A 228
ALA A 251
GLY A 255
ASN A 335
PRO A 337
 None
 0.81A 2y7hB-3khkA:
25.3		 2y7hB-3khkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		6 / 12 THR A 228
ALA A 251
GLY A 253
GLY A 256
ASN A 335
PRO A 337
 None
 0.79A 2y7hC-3khkA:
25.4		 2y7hC-3khkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 THR A 228
ALA A 251
GLY A 255
ASN A 335
PRO A 337
 None
 0.82A 2y7hC-3khkA:
25.4		 2y7hC-3khkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		3 / 3 ASP A 519
PHE A 520
LEU A 522
 None
 0.71A 2zi9A-3khkA:
undetectable		 2zi9A-3khkA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 GLY A 253
SER A 254
SER A 290
ASN A 335
PRO A 337
 None
 0.63A 3v8vA-3khkA:
11.9		 3v8vA-3khkA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 11 GLY A 253
SER A 290
ASP A 317
ASN A 335
PRO A 337
 None
 0.77A 3v8vB-3khkA:
8.9		 3v8vB-3khkA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		3 / 3 TRP A 354
TRP A 344
THR A 369
 None
 1.39A 4bboB-3khkA:
undetectable		 4bboB-3khkA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		4 / 6 LEU A 297
LEU A 212
GLU A 209
TYR A 208
 None
 1.00A 4f3tA-3khkA:
undetectable		 4f3tA-3khkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		4 / 4 LEU A 425
PRO A 426
LEU A 429
ILE A 232
 None
 0.94A 4f4dB-3khkA:
undetectable		 4f4dB-3khkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		3 / 3 THR A 294
PRO A 292
THR A 293
 None
 0.86A 4hivD-3khkA:
undetectable		 4hivD-3khkA:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 TYR A 226
ASN A 432
GLY A 253
SER A 254
ASN A 291
 None
 1.23A 4obwA-3khkA:
11.8		 4obwA-3khkA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A  42
LEU A  39
GLY A  38
MET A 300
ILE A 160
 None
 1.24A 4oktA-3khkA:
undetectable		 4oktA-3khkA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		4 / 5 SER A 389
GLY A 388
GLU A 420
PHE A 441
 None
 1.31A 4r82A-3khkA:
undetectable
4r82B-3khkA:
undetectable		 4r82A-3khkA:
15.35
4r82B-3khkA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		4 / 6 LEU A 297
LEU A 212
GLU A 209
TYR A 208
 None
 0.94A 4w5nA-3khkA:
undetectable		 4w5nA-3khkA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		3 / 3 THR A 228
ASP A 249
GLU A 289
 None
 0.86A 5fa8A-3khkA:
undetectable		 5fa8A-3khkA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ASP A 317
PRO A 337
GLY A 253
GLU A 289
SER A 290
 None
 0.63A 5hfjA-3khkA:
2.9		 5hfjA-3khkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		6 / 12 ASP A 317
PRO A 337
GLY A 253
SER A 254
GLU A 289
SER A 290
 None
 0.55A 5hfjD-3khkA:
2.5		 5hfjD-3khkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ASP A 317
GLY A 253
SER A 254
GLU A 289
SER A 290
 None
 0.55A 5hfjE-3khkA:
2.8		 5hfjE-3khkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ASP A 317
ALA A 316
GLY A 253
SER A 254
GLU A 289
 None
 1.29A 5hfjF-3khkA:
2.9		 5hfjF-3khkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ASP A 317
PRO A 250
GLY A 253
SER A 254
GLU A 289
 None
 1.24A 5hfjF-3khkA:
2.9		 5hfjF-3khkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		6 / 12 ASP A 317
PRO A 337
GLY A 253
SER A 254
GLU A 289
SER A 290
 None
 0.75A 5hfjF-3khkA:
2.9		 5hfjF-3khkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 11 GLY A 253
GLU A 289
ASN A 291
ASP A 317
PRO A 337
 None
 0.72A 5hjiA-3khkA:
11.6		 5hjiA-3khkA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		4 / 8 VAL A 423
LEU A 425
ILE A 483
MET A 239
 None
 0.75A 5nujA-3khkA:
undetectable		 5nujA-3khkA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		4 / 7 GLN A 503
ASP A 463
ALA A 424
LEU A 425
 None
 1.01A 5nwvA-3khkA:
undetectable		 5nwvA-3khkA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		4 / 7 ALA A 251
GLY A 253
GLY A 255
GLU A 289
 None
 0.43A 5ybbB-3khkA:
27.5		 5ybbB-3khkA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ASP A 249
LEU A 425
LEU A 235
SER A 260
GLY A 224
 None
 1.10A 6b0iB-3khkA:
undetectable		 6b0iB-3khkA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 11 ILE A 232
LEU A 235
MET A 239
LEU A 392
PHE A 441
 None
 1.17A 6hupA-3khkA:
1.3
6hupB-3khkA:
undetectable		 6hupA-3khkA:
9.31
6hupB-3khkA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT
(Methanosarcina
mazei) 		5 / 11 ILE A 232
LEU A 235
MET A 390
LEU A 392
PHE A 441
 None
 1.13A 6hupA-3khkA:
1.3
6hupB-3khkA:
undetectable		 6hupA-3khkA:
9.31
6hupB-3khkA:
10.93