SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3khp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 236
ALA A 238
THR A 252
ILE A 254
LEU A 225
 None
 1.15A 1ddsA-3khpA:
undetectable		 1ddsA-3khpA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 221
ALA A 223
MET A 171
THR A 252
 None
 1.37A 3vasB-3khpA:
undetectable		 3vasB-3khpA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 231
GLN A  51
GLY A 228
VAL A 222
ASN A 232
 None
 1.18A 4a3uA-3khpA:
undetectable		 4a3uA-3khpA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  67
GLY A  65
GLY A  71
ASN A  74
PHE A  73
 None
 0.99A 4obwA-3khpA:
undetectable		 4obwA-3khpA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  67
GLY A  65
GLY A  71
ASN A  74
PHE A  73
 None
 1.07A 4obwB-3khpA:
undetectable		 4obwB-3khpA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  67
GLY A  65
GLY A  71
ASN A  74
PHE A  73
 None
 1.07A 4obwD-3khpA:
undetectable		 4obwD-3khpA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 236
ALA A 238
THR A 252
ILE A 254
LEU A 225
 None
 1.13A 5e8qB-3khpA:
undetectable		 5e8qB-3khpA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 148
ASP A 108
ASN A 114
 None
 0.58A 5jglA-3khpA:
undetectable		 5jglA-3khpA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 131
GLY A 123
VAL A 100
SER A  98
 None
 0.94A 5m8rC-3khpA:
undetectable		 5m8rC-3khpA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 236
ALA A 238
THR A 252
ILE A 254
LEU A 225
 None
 1.15A 5ujxB-3khpA:
undetectable		 5ujxB-3khpA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_SALA601_1
(SALICYLATE-AMP
LIGASE)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 CYH A  60
GLY A 121
VAL A  99
GLY A 123
LEU A  97
 None
 1.02A 5wm2A-3khpA:
undetectable		 5wm2A-3khpA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 139
VAL A 118
GLY A  84
THR A  55
LEU A 280
 None
 0.97A 5x24A-3khpA:
undetectable		 5x24A-3khpA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 284
GLY A 260
ALA A 238
ARG A 239
PRO A 158
 None
 1.07A 5zvgA-3khpA:
undetectable		 5zvgA-3khpA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3khp MAOC FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 284
GLY A 260
ALA A 238
ARG A 239
PRO A 158
 None
 1.08A 5zvgB-3khpA:
undetectable		 5zvgB-3khpA:
21.88