SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3khs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 12 GLY A 115
GLU A 198
VAL A 214
MET A 216
SER A 239
None
None
None
TRS  A 294 (-3.7A)
None
0.68A 1jdvE-3khsA:
23.3
1jdvF-3khsA:
22.5
1jdvE-3khsA:
25.68
1jdvF-3khsA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 115
GLU A 198
SER A 239
ASN A 240
ILE A 242
None
1.01A 1odiA-3khsA:
15.4
1odiA-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 116
GLU A 198
SER A 239
ASN A 240
ILE A 242
None
1.39A 1odiA-3khsA:
15.4
1odiA-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 115
GLU A 198
SER A 239
ASN A 240
ILE A 242
None
0.99A 1odiB-3khsA:
21.3
1odiB-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 116
GLU A 198
SER A 239
ASN A 240
ILE A 242
None
1.40A 1odiB-3khsA:
21.3
1odiB-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 115
GLU A 198
SER A 239
ASN A 240
ILE A 242
None
1.01A 1odiC-3khsA:
21.2
1odiC-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 116
GLU A 198
SER A 239
ASN A 240
ILE A 242
None
1.40A 1odiC-3khsA:
21.2
1odiC-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 MET A 216
GLY A 116
SER A 239
ASN A 240
ILE A 242
TRS  A 294 (-3.7A)
None
None
None
None
1.11A 1odiC-3khsA:
21.2
1odiC-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 115
GLU A 198
SER A 239
ASN A 240
ILE A 242
None
0.98A 1odiD-3khsA:
20.9
1odiD-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 116
GLU A 198
SER A 239
ASN A 240
ILE A 242
None
1.41A 1odiD-3khsA:
20.9
1odiD-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 115
GLU A 198
SER A 239
ASN A 240
ILE A 242
None
0.98A 1odiE-3khsA:
21.0
1odiE-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 116
GLU A 198
SER A 239
ASN A 240
ILE A 242
None
1.41A 1odiE-3khsA:
21.0
1odiE-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 115
GLU A 198
SER A 239
ASN A 240
ILE A 242
None
0.99A 1odiF-3khsA:
21.0
1odiF-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 116
GLU A 198
SER A 239
ASN A 240
ILE A 242
None
1.42A 1odiF-3khsA:
21.0
1odiF-3khsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 8 GLY A 115
VAL A 214
MET A 216
ILE A 242
None
None
TRS  A 294 (-3.7A)
None
0.58A 1pk7B-3khsA:
22.3
1pk7B-3khsA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 8 GLY A 115
VAL A 214
MET A 216
SER A 239
None
None
TRS  A 294 (-3.7A)
None
0.50A 1pk7B-3khsA:
22.3
1pk7B-3khsA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 115
VAL A 214
MET A 216
SER A 239
ILE A 242
None
None
TRS  A 294 (-3.7A)
None
None
0.69A 1pk9C-3khsA:
21.8
1pk9C-3khsA:
24.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
7 / 10 GLY A 115
PHE A 197
GLU A 198
VAL A 214
GLY A 215
MET A 216
ASN A 240
None
TRS  A 294 (-4.9A)
None
None
TRS  A 294 ( 3.9A)
TRS  A 294 (-3.7A)
None
0.52A 1pwyE-3khsA:
37.7
1pwyE-3khsA:
49.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 10 GLY A 215
PHE A 197
GLU A 198
VAL A 192
GLY A 194
TRS  A 294 ( 3.9A)
TRS  A 294 (-4.9A)
None
None
None
1.11A 1pwyE-3khsA:
37.7
1pwyE-3khsA:
49.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 10 GLY A 215
PHE A 197
VAL A 192
GLY A 194
VAL A 214
TRS  A 294 ( 3.9A)
TRS  A 294 (-4.9A)
None
None
None
1.22A 1pwyE-3khsA:
37.7
1pwyE-3khsA:
49.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
7 / 10 GLY A 115
PHE A 197
GLU A 198
VAL A 214
GLY A 215
MET A 216
ASN A 240
None
TRS  A 294 (-4.9A)
None
None
TRS  A 294 ( 3.9A)
TRS  A 294 (-3.7A)
None
0.43A 1v3qE-3khsA:
37.5
1v3qE-3khsA:
49.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 10 GLY A 215
PHE A 197
GLU A 198
VAL A 192
GLY A 194
TRS  A 294 ( 3.9A)
TRS  A 294 (-4.9A)
None
None
None
1.18A 1v3qE-3khsA:
37.5
1v3qE-3khsA:
49.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 8 LEU A 103
ILE A  50
TYR A  47
PHE A  53
PHE A  67
None
1.37A 2weyB-3khsA:
undetectable
2weyB-3khsA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 5 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.02A 2y69C-3khsA:
undetectable
2y69J-3khsA:
undetectable
2y69C-3khsA:
21.71
2y69J-3khsA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 5 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.09A 2y69P-3khsA:
undetectable
2y69W-3khsA:
undetectable
2y69P-3khsA:
21.71
2y69W-3khsA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 5 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.03A 3abmC-3khsA:
undetectable
3abmJ-3khsA:
undetectable
3abmC-3khsA:
21.71
3abmJ-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 5 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.06A 3abmP-3khsA:
undetectable
3abmW-3khsA:
undetectable
3abmP-3khsA:
21.71
3abmW-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 5 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.08A 3ag3C-3khsA:
undetectable
3ag3J-3khsA:
undetectable
3ag3C-3khsA:
21.71
3ag3J-3khsA:
17.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 GLY A 115
GLU A 198
GLY A 215
MET A 216
None
None
TRS  A 294 ( 3.9A)
TRS  A 294 (-3.7A)
0.83A 3e9rA-3khsA:
36.8
3e9rA-3khsA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 GLY A 115
GLY A 215
MET A 216
ASN A 240
None
TRS  A 294 ( 3.9A)
TRS  A 294 (-3.7A)
None
0.49A 3e9rA-3khsA:
36.8
3e9rA-3khsA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 GLY A 115
GLU A 198
GLY A 215
MET A 216
None
None
TRS  A 294 ( 3.9A)
TRS  A 294 (-3.7A)
0.86A 3e9rC-3khsA:
37.0
3e9rC-3khsA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 GLY A 115
GLY A 215
MET A 216
ASN A 240
None
TRS  A 294 ( 3.9A)
TRS  A 294 (-3.7A)
None
0.50A 3e9rC-3khsA:
37.0
3e9rC-3khsA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
9 / 12 SER A  30
TYR A  85
ALA A 113
GLY A 115
GLU A 198
VAL A 214
GLY A 215
MET A 216
ASN A 240
PO4  A 290 (-2.6A)
None
PO4  A 290 ( 4.0A)
None
None
None
TRS  A 294 ( 3.9A)
TRS  A 294 (-3.7A)
None
0.63A 3f8wA-3khsA:
38.2
3f8wA-3khsA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
9 / 12 SER A  30
HIS A  83
TYR A  85
GLY A 115
GLU A 198
VAL A 214
GLY A 215
MET A 216
ASN A 240
PO4  A 290 (-2.6A)
PO4  A 290 (-4.0A)
None
None
None
None
TRS  A 294 ( 3.9A)
TRS  A 294 (-3.7A)
None
0.62A 3f8wB-3khsA:
38.1
3f8wB-3khsA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
10 / 12 SER A  30
HIS A  83
TYR A  85
ALA A 113
GLY A 115
GLU A 198
VAL A 214
GLY A 215
MET A 216
ASN A 240
PO4  A 290 (-2.6A)
PO4  A 290 (-4.0A)
None
PO4  A 290 ( 4.0A)
None
None
None
TRS  A 294 ( 3.9A)
TRS  A 294 (-3.7A)
None
0.62A 3f8wC-3khsA:
38.4
3f8wC-3khsA:
46.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 LEU A 271
VAL A 214
VAL A 129
ILE A 238
None
1.26A 3k5vB-3khsA:
undetectable
3k5vB-3khsA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 THR A 218
ASN A 112
GLY A  29
ILE A  26
None
PO4  A 290 (-4.9A)
PO4  A 290 (-3.5A)
None
0.99A 3w9tF-3khsA:
undetectable
3w9tF-3khsA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
3 / 3 ASP A 125
ARG A 122
ASP A 212
None
0.87A 4fp9A-3khsA:
undetectable
4fp9A-3khsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 9 THR A 145
ALA A  90
THR A  89
ALA A  93
GLY A 140
None
1.10A 4qvnK-3khsA:
undetectable
4qvnL-3khsA:
undetectable
4qvnK-3khsA:
22.84
4qvnL-3khsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 9 THR A 145
ALA A  90
THR A  89
ALA A  93
GLY A 140
None
1.10A 4qvnY-3khsA:
undetectable
4qvnZ-3khsA:
undetectable
4qvnY-3khsA:
22.84
4qvnZ-3khsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 9 THR A 145
ALA A  90
THR A  89
ALA A  93
GLY A 140
None
1.08A 4qvqK-3khsA:
undetectable
4qvqL-3khsA:
undetectable
4qvqK-3khsA:
22.49
4qvqL-3khsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 9 THR A 145
ALA A  90
THR A  89
ALA A  93
GLY A 140
None
1.08A 4qvqY-3khsA:
undetectable
4qvqZ-3khsA:
undetectable
4qvqY-3khsA:
22.49
4qvqZ-3khsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 THR A 145
ALA A  90
THR A  89
ALA A  93
GLY A 140
None
1.08A 4qvwK-3khsA:
undetectable
4qvwL-3khsA:
undetectable
4qvwK-3khsA:
21.00
4qvwL-3khsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 THR A 145
ALA A  90
THR A  89
ALA A  93
GLY A 140
None
1.08A 4qvwY-3khsA:
undetectable
4qvwZ-3khsA:
undetectable
4qvwY-3khsA:
21.00
4qvwZ-3khsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 9 THR A 145
ALA A  90
THR A  89
ALA A  93
GLY A 140
None
1.11A 4qwuK-3khsA:
undetectable
4qwuL-3khsA:
undetectable
4qwuK-3khsA:
22.49
4qwuL-3khsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 9 THR A 145
ALA A  90
THR A  89
ALA A  93
GLY A 140
None
1.11A 4qwuY-3khsA:
undetectable
4qwuZ-3khsA:
undetectable
4qwuY-3khsA:
22.49
4qwuZ-3khsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 12 VAL A  70
VAL A 272
ILE A 276
ILE A  35
GLY A  33
None
0.91A 4y8wC-3khsA:
undetectable
4y8wC-3khsA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.17A 5b1bC-3khsA:
undetectable
5b1bJ-3khsA:
undetectable
5b1bC-3khsA:
21.71
5b1bJ-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 GLY A 115
VAL A 214
MET A 216
SER A 239
ILE A 242
None
None
TRS  A 294 (-3.7A)
None
None
0.67A 5i3cC-3khsA:
22.5
5i3cC-3khsA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 LEU A  65
SER A  64
ILE A  50
PHE A  53
None
0.70A 5jw1A-3khsA:
undetectable
5jw1A-3khsA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 9 THR A 145
ALA A  90
THR A  89
ALA A  93
GLY A 140
None
1.05A 5l5zK-3khsA:
undetectable
5l5zL-3khsA:
undetectable
5l5zK-3khsA:
21.28
5l5zL-3khsA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 9 THR A 145
ALA A  90
THR A  89
ALA A  93
GLY A 140
None
1.05A 5l5zY-3khsA:
undetectable
5l5zZ-3khsA:
undetectable
5l5zY-3khsA:
21.28
5l5zZ-3khsA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 7 THR A 111
LEU A 110
VAL A 162
TYR A 163
None
0.96A 5ov9A-3khsA:
undetectable
5ov9A-3khsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 8 THR A 111
PHE A 100
VAL A 235
ILE A 107
None
1.04A 5vkqB-3khsA:
undetectable
5vkqC-3khsA:
undetectable
5vkqB-3khsA:
10.41
5vkqC-3khsA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 5 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.02A 5wauC-3khsA:
undetectable
5wauJ-3khsA:
undetectable
5wauC-3khsA:
21.71
5wauJ-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 5 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.00A 5wauc-3khsA:
undetectable
5wauj-3khsA:
undetectable
5wauc-3khsA:
21.71
5wauj-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 5 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.05A 5xdqC-3khsA:
undetectable
5xdqJ-3khsA:
undetectable
5xdqC-3khsA:
21.71
5xdqJ-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 5 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.05A 5xdqP-3khsA:
undetectable
5xdqW-3khsA:
undetectable
5xdqP-3khsA:
21.71
5xdqW-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 TYR A 189
LEU A 135
GLU A 198
LEU A 206
None
1.46A 5xooA-3khsA:
undetectable
5xooA-3khsA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 11 ALA A 264
ASP A  37
VAL A 109
ILE A  26
ILE A 276
None
1.14A 5y80A-3khsA:
undetectable
5y80A-3khsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
6 / 12 LEU A  39
ILE A  26
GLY A  25
LEU A 167
VAL A 275
ILE A 276
None
1.42A 5ycnA-3khsA:
undetectable
5ycnA-3khsA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.05A 5z84P-3khsA:
undetectable
5z84W-3khsA:
undetectable
5z84P-3khsA:
21.71
5z84W-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.08A 5z85P-3khsA:
undetectable
5z85W-3khsA:
undetectable
5z85P-3khsA:
21.71
5z85W-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.02A 5z86C-3khsA:
undetectable
5z86J-3khsA:
undetectable
5z86C-3khsA:
21.71
5z86J-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.04A 5z86P-3khsA:
undetectable
5z86W-3khsA:
undetectable
5z86P-3khsA:
21.71
5z86W-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.05A 5zcoP-3khsA:
undetectable
5zcoW-3khsA:
undetectable
5zcoP-3khsA:
21.71
5zcoW-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.01A 5zcpC-3khsA:
undetectable
5zcpJ-3khsA:
undetectable
5zcpC-3khsA:
21.71
5zcpJ-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
4 / 6 PHE A  95
PHE A  53
LEU A  65
PHE A  67
None
1.07A 5zcpP-3khsA:
undetectable
5zcpW-3khsA:
undetectable
5zcpP-3khsA:
21.71
5zcpW-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus)
5 / 12 MET A 127
ILE A 238
VAL A 272
VAL A 275
SER A 265
None
1.40A 6bzoC-3khsA:
undetectable
6bzoC-3khsA:
12.49