SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3khw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3khw POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 LEU A 618
PHE A 621
ALA A 622
LEU A 599
 None
 0.95A 1ukbA-3khwA:
undetectable		 1ukbA-3khwA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 3khw POLYMERASE PB2
(Influenza
A
virus) 		5 / 12 ILE A 647
VAL A 640
TYR A 550
GLN A 581
PHE A 621
 None
 1.11A 2ziaB-3khwA:
undetectable		 2ziaB-3khwA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 3khw POLYMERASE PB2
(Influenza
A
virus) 		4 / 7 VAL A 638
LEU A 546
TYR A 550
GLN A 581
 None
 0.82A 3qeoB-3khwA:
undetectable		 3qeoB-3khwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 3khw POLYMERASE PB2
(Influenza
A
virus) 		5 / 10 TYR A 550
ILE A 553
ILE A 554
TRP A 557
TYR A 658
 None
 0.88A 5mvnD-3khwA:
undetectable		 5mvnD-3khwA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 3khw POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 VAL A 667
LEU A 571
MET A 603
ARG A 597
 None
 1.31A 6brdB-3khwA:
undetectable		 6brdB-3khwA:
21.08