SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3khy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		4 / 7 MET A 275
SER A 297
ALA A 292
ILE A 293
 None
 0.88A 1fxhA-3khyA:
undetectable
1fxhB-3khyA:
undetectable		 1fxhA-3khyA:
18.75
1fxhB-3khyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		4 / 8 MET A 275
SER A 297
ALA A 292
ILE A 293
 None
 0.94A 1pnlA-3khyA:
undetectable
1pnlB-3khyA:
undetectable		 1pnlA-3khyA:
18.75
1pnlB-3khyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		5 / 12 ALA A 139
ASN A   8
HIS A 121
ILE A  35
TYR A  59
 None
 1.50A 1xvaB-3khyA:
0.3		 1xvaB-3khyA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		4 / 5 CYH A 205
PRO A 224
THR A 370
THR A 320
 None
 1.24A 1ymxB-3khyA:
undetectable		 1ymxB-3khyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		3 / 3 CYH A 128
PHE A 127
PHE A  63
 None
 1.03A 3cr5X-3khyA:
undetectable		 3cr5X-3khyA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		3 / 3 HIS A 121
PHE A 127
PHE A  63
 None
 0.55A 3lk0D-3khyA:
undetectable		 3lk0D-3khyA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		5 / 12 GLY A  30
TYR A  59
CYH A  40
LYS A  41
ILE A  35
 None
 1.48A 3opeA-3khyA:
undetectable		 3opeA-3khyA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		5 / 12 GLY A 265
ALA A 292
ALA A 289
ALA A 282
ASP A 286
 None
 0.98A 3sudD-3khyA:
undetectable		 3sudD-3khyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		4 / 5 LEU A 201
GLY A 321
THR A 370
VAL A 181
 None
 0.93A 3wrkD-3khyA:
undetectable		 3wrkD-3khyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		4 / 7 PHE A 303
TYR A 307
ILE A 216
HIS A 146
 None
 1.18A 4g5jA-3khyA:
undetectable		 4g5jA-3khyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		5 / 10 ASN A 371
GLY A 322
ILE A 323
VAL A 318
VAL A 181
 None
 1.09A 4j5jB-3khyA:
undetectable		 4j5jB-3khyA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		5 / 11 VAL A 210
ALA A 209
GLY A 175
PHE A 145
SER A 206
 None
 1.21A 4mm9A-3khyA:
undetectable		 4mm9A-3khyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		5 / 12 ILE A 245
ILE A 295
LEU A 291
GLY A 268
ASN A 258
 None
 0.97A 4o1eA-3khyA:
undetectable		 4o1eA-3khyA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		5 / 12 ILE A 245
ILE A 295
LEU A 291
GLY A 268
ASN A 258
 None
 0.98A 4o1eB-3khyA:
undetectable		 4o1eB-3khyA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		4 / 5 THR A 370
THR A 320
THR A 218
HIS A 146
 None
 1.21A 4pgfB-3khyA:
2.4		 4pgfB-3khyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		5 / 12 GLY A  30
TYR A  59
CYH A  40
LYS A  41
ILE A  35
 None
 1.40A 4ynpA-3khyA:
undetectable		 4ynpA-3khyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		5 / 12 LEU A 228
HIS A 178
GLY A 202
GLY A 231
HIS A 174
 None
 1.21A 5nnaC-3khyA:
undetectable		 5nnaC-3khyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		4 / 5 THR A 320
THR A 218
HIS A 146
GLY A 204
 None
 1.04A 6gbnC-3khyA:
undetectable		 6gbnC-3khyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 3khy PROPIONATE KINASE
(Francisella
tularensis) 		5 / 12 VAL A 304
VAL A 300
PHE A 343
PHE A 319
ILE A 345
 None
 1.32A 6mxtA-3khyA:
undetectable		 6mxtA-3khyA:
23.12