SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ki8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		5 / 12 VAL A 173
PHE A 124
LEU A  95
ASN A  49
PHE A  50
 ACY  A3001 (-3.8A)
None
None
None
None
 1.33A 1nw3A-3ki8A:
undetectable		 1nw3A-3ki8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		4 / 6 PHE A 206
ASN A  10
ILE A  13
GLY A  47
 None
 0.85A 1oniA-3ki8A:
undetectable
1oniB-3ki8A:
undetectable		 1oniA-3ki8A:
21.83
1oniB-3ki8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		4 / 6 ILE A  13
GLU A 201
PHE A 123
ARG A 119
 None
 1.17A 1oniA-3ki8A:
undetectable
1oniC-3ki8A:
undetectable		 1oniA-3ki8A:
21.83
1oniC-3ki8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		4 / 6 PHE A 206
ASN A  10
ILE A  13
GLY A  47
 None
 0.89A 1oniD-3ki8A:
undetectable
1oniF-3ki8A:
undetectable		 1oniD-3ki8A:
21.83
1oniF-3ki8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		4 / 7 PHE A 138
VAL A  38
VAL A 165
VAL A 141
 None
 0.95A 2qbnA-3ki8A:
undetectable		 2qbnA-3ki8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		4 / 5 VAL A  39
VAL A  38
GLN A  36
PHE A 134
 None
 1.28A 3bjwH-3ki8A:
undetectable		 3bjwH-3ki8A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		4 / 5 VAL A  39
VAL A  38
GLN A  36
PHE A 134
 None
 1.32A 3bjwB-3ki8A:
undetectable		 3bjwB-3ki8A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		4 / 6 ASN A 171
ARG A 197
ASN A  49
GLU A 201
 None
 1.44A 3galA-3ki8A:
undetectable		 3galA-3ki8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		4 / 6 ASN A 171
ARG A 197
ASN A  49
GLU A 201
 None
 1.46A 3galB-3ki8A:
undetectable		 3galB-3ki8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		4 / 7 GLU A 120
TYR A 111
GLU A  42
TYR A  48
 None
 1.33A 3ku9B-3ki8A:
undetectable		 3ku9B-3ki8A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		5 / 12 ILE A 166
VAL A 143
ILE A  27
LEU A  40
PRO A  41
 None
 0.80A 3mb5A-3ki8A:
undetectable		 3mb5A-3ki8A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		6 / 12 LEU A  37
LEU A  40
VAL A  81
GLY A 103
ALA A  76
LEU A  72
 None
 1.46A 3pghC-3ki8A:
undetectable		 3pghC-3ki8A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		6 / 12 LEU A  37
LEU A  40
VAL A  81
GLY A 103
ALA A  76
LEU A  72
 None
 1.46A 3pghD-3ki8A:
undetectable		 3pghD-3ki8A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		5 / 12 VAL A 190
ASN A 188
GLU A 153
HIS A 168
VAL A 133
 None
 1.34A 4a97B-3ki8A:
undetectable
4a97C-3ki8A:
undetectable		 4a97B-3ki8A:
21.45
4a97C-3ki8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		3 / 3 ARG A 119
GLU A  51
ASN A  49
 None
 0.88A 4imaD-3ki8A:
2.4		 4imaD-3ki8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		3 / 3 ARG A 119
GLU A  51
ASN A  49
 None
 0.91A 4ip7D-3ki8A:
undetectable		 4ip7D-3ki8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		5 / 12 ASP A 148
SER A 154
ALA A 163
ALA A 159
TYR A 111
 None
 1.30A 4u15B-3ki8A:
undetectable		 4u15B-3ki8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		5 / 12 ASP A 148
SER A 154
ALA A 163
ALA A 159
TYR A 111
 None
 1.37A 5cxvA-3ki8A:
undetectable		 5cxvA-3ki8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA302_0
(AMIDASE)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		5 / 9 GLU A  42
TYR A  48
LYS A 113
GLU A 120
LEU A 172
 None
None
None
None
ACY  A3001 (-4.2A)
 0.85A 5ny7A-3ki8A:
33.9		 5ny7A-3ki8A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)
(Pyrococcus
abyssi) 		5 / 12 GLY A  86
THR A  46
ILE A  27
VAL A  75
ILE A  83
 None
 0.92A 6emuA-3ki8A:
undetectable		 6emuA-3ki8A:
21.77