SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kin'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 3kin KINESIN HEAVY CHAIN
(Rattus
norvegicus) 		4 / 6 LEU A 210
ASP A 145
MET B 284
LEU B 288
 None
 1.10A 1errB-3kinA:
undetectable		 1errB-3kinA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 8 SER B 305
ARG A  16
PHE A  15
ASN B 310
 None
 1.32A 1p6kA-3kinB:
undetectable		 1p6kA-3kinB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 8 SER B 305
ARG A  16
PHE A  15
ASN B 310
 None
 1.28A 1p6kB-3kinB:
undetectable		 1p6kB-3kinB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 8 SER B 305
ARG A  16
PHE A  15
ASN B 310
 None
 1.32A 1rs6B-3kinB:
undetectable		 1rs6B-3kinB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 8 SER B 305
ARG A  16
PHE A  15
ASN B 310
 None
 1.20A 1rs7B-3kinB:
undetectable		 1rs7B-3kinB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 7 TYR B 279
THR A  81
THR B 298
VAL B 265
 None
 1.13A 1tv8A-3kinB:
undetectable		 1tv8A-3kinB:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 8 SER B 305
ARG A  16
PHE A  15
ASN B 310
 None
 1.35A 1zzqA-3kinB:
undetectable		 1zzqA-3kinB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 8 SER B 305
ARG A  16
PHE A  15
ASN B 310
 None
 1.30A 1zzqB-3kinB:
undetectable		 1zzqB-3kinB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 8 SER B 305
ARG A  16
PHE A  15
ASN B 310
 None
 1.26A 1zzuB-3kinB:
undetectable		 1zzuB-3kinB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 3kin KINESIN HEAVY CHAIN
(Rattus
norvegicus) 		5 / 12 LEU B 259
ILE B 300
ILE A   9
ILE B 266
TYR A  85
 None
 1.42A 2efjA-3kinB:
undetectable		 2efjA-3kinB:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 8 TYR B 279
THR A  81
THR B 298
VAL B 265
 None
 1.12A 2fb2A-3kinB:
undetectable		 2fb2A-3kinB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 7 TYR B 279
THR A  81
THR B 298
VAL B 265
 None
 1.13A 2fb2B-3kinB:
undetectable		 2fb2B-3kinB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 3kin KINESIN HEAVY CHAIN
(Rattus
norvegicus) 		4 / 5 LEU A 210
ASP A 145
MET B 284
LEU B 288
 None
 1.07A 2jfaA-3kinA:
undetectable		 2jfaA-3kinA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 3kin KINESIN HEAVY CHAIN
(Rattus
norvegicus) 		5 / 12 ALA B 268
LEU B 269
ALA B 270
THR B 326
ILE B 300
 None
 1.05A 2jjpA-3kinB:
undetectable		 2jjpA-3kinB:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 3kin KINESIN HEAVY CHAIN
(Rattus
norvegicus) 		4 / 5 LEU A 210
ASP A 145
MET B 284
LEU B 288
 None
 1.10A 2qxsA-3kinA:
undetectable		 2qxsA-3kinA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 3kin KINESIN HEAVY CHAIN
(Rattus
norvegicus) 		4 / 5 LEU A 210
ASP A 145
MET B 284
LEU B 288
 None
 1.10A 2qxsB-3kinA:
undetectable		 2qxsB-3kinA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3kin KINESIN HEAVY CHAIN
(Rattus
norvegicus) 		5 / 12 ALA A 113
ILE A 109
SER A 207
LEU A 147
ARG A 172
 None
 1.25A 3cl9A-3kinA:
undetectable		 3cl9A-3kinA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 12 GLY B 294
GLY B 293
VAL A  74
ASP A  73
LEU A 230
 None
 0.81A 3m6vA-3kinB:
undetectable		 3m6vA-3kinB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 12 GLY B 294
GLY B 293
VAL A  74
ASP A  73
LEU A 230
 None
 0.80A 3m6vB-3kinB:
undetectable		 3m6vB-3kinB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 12 GLY B 294
GLY B 293
VAL A  74
ASP A  73
LEU A 230
 None
 0.82A 3m6wA-3kinB:
undetectable		 3m6wA-3kinB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 3kin KINESIN HEAVY CHAIN
(Rattus
norvegicus) 		4 / 8 ASP B 290
GLY B 294
TYR B 279
PRO A 164
 None
 1.04A 3s3mA-3kinB:
undetectable		 3s3mA-3kinB:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3kin KINESIN HEAVY CHAIN
(Rattus
norvegicus) 		4 / 6 PHE A  83
GLY B 263
LEU B 292
VAL B 265
 None
 0.83A 4dubB-3kinA:
undetectable		 4dubB-3kinA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3kin KINESIN HEAVY CHAIN
(Rattus
norvegicus) 		4 / 8 GLY A  86
ILE B 302
THR B 314
THR B 317
 None
 0.83A 4em2A-3kinA:
undetectable		 4em2A-3kinA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3kin KINESIN HEAVY CHAIN
(Rattus
norvegicus) 		5 / 10 ILE A 184
ILE A 109
VAL A 180
ASP A 115
ILE A 211
 None
 1.25A 5lg3H-3kinA:
undetectable		 5lg3H-3kinA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3kin KINESIN HEAVY CHAIN
(Rattus
norvegicus) 		4 / 8 THR B 314
THR B 317
TYR A  85
PRO A  55
 None
 1.34A 5x2sI-3kinB:
undetectable
5x2sJ-3kinB:
undetectable
5x2sK-3kinB:
undetectable		 5x2sI-3kinB:
20.55
5x2sJ-3kinB:
19.18
5x2sK-3kinB:
20.55