SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3kio RIBONUCLEASE H2
SUBUNIT A
(Mus
musculus) 		5 / 12 LEU A 101
SER A 103
LEU A 107
THR A 121
TRP A 239
 None
 1.35A 1kw0A-3kioA:
undetectable		 1kw0A-3kioA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 3kio RIBONUCLEASE H2
SUBUNIT B
(Mus
musculus) 		3 / 3 LEU B  19
PRO B  20
LEU B  23
 None
 0.46A 2qd5B-3kioB:
undetectable		 2qd5B-3kioB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kio RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus) 		5 / 9 PRO C  33
LEU C  32
LEU C  68
ALA C  61
PHE C  48
 None
 1.20A 2vcvD-3kioC:
undetectable		 2vcvD-3kioC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kio RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus) 		5 / 9 PRO C  33
LEU C  32
LEU C  68
ALA C  61
PHE C  48
 None
 1.13A 2vcvE-3kioC:
undetectable		 2vcvE-3kioC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kio RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus) 		5 / 9 PRO C  33
LEU C  32
LEU C  68
ALA C  61
PHE C  48
 None
 1.12A 2vcvH-3kioC:
undetectable		 2vcvH-3kioC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kio RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus) 		5 / 9 PRO C  33
LEU C  32
LEU C  68
ALA C  61
PHE C  48
 None
 1.11A 2vcvI-3kioC:
undetectable		 2vcvI-3kioC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3kio RIBONUCLEASE H2
SUBUNIT A
(Mus
musculus) 		5 / 9 PHE A 173
PRO A 174
VAL A 175
GLY A  32
ILE A 126
 None
 1.31A 3csjB-3kioA:
undetectable		 3csjB-3kioA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3kio RIBONUCLEASE H2
SUBUNIT A
(Mus
musculus) 		4 / 8 VAL A 136
TYR A 128
ILE A 126
GLN A 127
 None
 0.88A 3remA-3kioA:
undetectable		 3remA-3kioA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3kio RIBONUCLEASE H2
SUBUNIT A
(Mus
musculus) 		4 / 8 VAL A 136
TYR A 128
ILE A 126
GLN A 127
 None
 0.87A 3remB-3kioA:
undetectable		 3remB-3kioA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3kio RIBONUCLEASE H2
SUBUNIT B
(Mus
musculus) 		3 / 3 LEU B  19
PRO B  20
LEU B  23
 None
 0.45A 3w1wB-3kioB:
undetectable		 3w1wB-3kioB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3kio RIBONUCLEASE H2
SUBUNIT A
(Mus
musculus) 		3 / 3 SER A 103
MET A 106
ASP A  95
 None
 0.89A 4mm4B-3kioA:
undetectable		 4mm4B-3kioA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus;
Mus
musculus) 		5 / 12 LEU A 221
PHE A 237
VAL A  41
GLU A 198
PHE C  47
 None
 1.18A 4q15B-3kioA:
undetectable		 4q15B-3kioA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus) 		5 / 12 GLY C  65
ASP C 102
VAL A 253
VAL C  44
PHE A 229
 None
 0.98A 4wnwA-3kioC:
undetectable		 4wnwA-3kioC:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus;
Mus
musculus) 		5 / 12 LEU A 221
PHE A 237
VAL A  41
GLU A 198
PHE C  47
 None
 1.21A 4ydqA-3kioA:
undetectable		 4ydqA-3kioA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3kio RIBONUCLEASE H2
SUBUNIT A
(Mus
musculus) 		3 / 3 ASN A 113
SER A 116
ARG A 153
 None
 0.89A 5b2qA-3kioA:
2.7		 5b2qA-3kioA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3kio RIBONUCLEASE H2
SUBUNIT A
(Mus
musculus) 		4 / 6 ARG A  13
GLY A  12
SER A  98
LEU A  97
 None
 0.87A 5bphA-3kioA:
undetectable		 5bphA-3kioA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus;
Mus
musculus) 		5 / 12 GLY C  67
THR A 104
ALA C  61
PHE A 229
LEU C  59
 None
 1.21A 5hw4A-3kioC:
undetectable		 5hw4A-3kioC:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus;
Mus
musculus) 		5 / 12 GLY C  67
THR A 104
ALA C  61
PHE A 229
LEU C  59
 None
 1.19A 5hw4C-3kioC:
undetectable		 5hw4C-3kioC:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3kio RIBONUCLEASE H2
SUBUNIT A
(Mus
musculus) 		5 / 12 ASP A 204
GLU A 198
LEU A 246
ARG A 222
LEU A  42
 None
 1.09A 5nd2B-3kioA:
undetectable		 5nd2B-3kioA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3kio RIBONUCLEASE H2
SUBUNIT B
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus) 		5 / 12 VAL C  44
ASP C  45
ASP C 102
HIS C  30
SER B  78
 None
 1.36A 5syfB-3kioC:
undetectable		 5syfB-3kioC:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus;
Mus
musculus) 		5 / 12 LEU A 221
PHE A 237
VAL A  41
GLU A 198
PHE C  47
 None
 1.10A 5xiqA-3kioA:
undetectable		 5xiqA-3kioA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus;
Mus
musculus) 		5 / 12 LEU A 221
PHE A 237
VAL A  41
GLU A 198
PHE C  47
 None
 1.17A 5xiqB-3kioA:
undetectable		 5xiqB-3kioA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus;
Mus
musculus) 		5 / 12 LEU A 221
PHE A 237
VAL A  41
GLU A 198
PHE C  47
 None
 1.07A 5xiqD-3kioA:
undetectable		 5xiqD-3kioA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus;
Mus
musculus) 		5 / 10 SER C  62
LEU A 117
SER A 105
ASP C 105
GLY A  12
 None
 1.45A 6dlzA-3kioC:
undetectable
6dlzD-3kioC:
undetectable		 6dlzA-3kioC:
20.61
6dlzD-3kioC:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus;
Mus
musculus) 		5 / 10 GLY A  12
SER C  62
LEU A 117
SER A 105
ASP C 105
 None
 1.45A 6dlzB-3kioA:
2.2
6dlzC-3kioA:
undetectable		 6dlzB-3kioA:
16.54
6dlzC-3kioA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus;
Mus
musculus) 		5 / 10 SER C  62
LEU A 117
SER A 105
ASP C 105
GLY A  12
 None
 1.46A 6dm1A-3kioC:
undetectable
6dm1D-3kioC:
undetectable		 6dm1A-3kioC:
20.61
6dm1D-3kioC:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C
(Mus
musculus;
Mus
musculus) 		5 / 10 GLY A  12
SER C  62
LEU A 117
SER A 105
ASP C 105
 None
 1.45A 6dm1B-3kioA:
2.1
6dm1C-3kioA:
undetectable		 6dm1B-3kioA:
16.54
6dm1C-3kioA:
16.54