SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3kip 3-DEHYDROQUINASE,
TYPE II
(Candida
albicans) 		4 / 8 LEU A  92
ILE A  76
ILE A  63
ILE A  59
 None
 0.83A 2bu8A-3kipA:
undetectable		 2bu8A-3kipA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3kip 3-DEHYDROQUINASE,
TYPE II
(Candida
albicans) 		4 / 6 LEU A  92
GLN A  52
ILE A   7
PHE A  99
 None
 1.15A 2jn3A-3kipA:
undetectable		 2jn3A-3kipA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3kip 3-DEHYDROQUINASE,
TYPE II
(Candida
albicans) 		5 / 11 LEU A   5
VAL A  71
GLY A  72
VAL A   1
ILE A   7
 None
 1.09A 2yy8A-3kipA:
5.1
2yy8B-3kipA:
4.2		 2yy8A-3kipA:
22.11
2yy8B-3kipA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3kip 3-DEHYDROQUINASE,
TYPE II
(Candida
albicans) 		5 / 9 ALA A  78
LEU A  12
VAL A 102
ILE A  31
THR A  82
 None
 1.26A 3freX-3kipA:
undetectable		 3freX-3kipA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kip 3-DEHYDROQUINASE,
TYPE II
(Candida
albicans) 		4 / 4 GLY A  87
GLU A  56
ASP A  61
ASP A  90
 None
TRS  A 157 (-2.8A)
None
None
 1.42A 3mb5A-3kipA:
undetectable		 3mb5A-3kipA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3kip 3-DEHYDROQUINASE,
TYPE II
(Candida
albicans) 		4 / 4 LEU A 130
GLY A 131
GLY A 134
THR A 136
 None
 0.80A 3si7A-3kipA:
undetectable		 3si7A-3kipA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3kip 3-DEHYDROQUINASE,
TYPE II
(Candida
albicans) 		4 / 5 LEU A 130
GLY A 131
GLY A 134
THR A 136
 None
 0.80A 3si7C-3kipA:
undetectable
3si7D-3kipA:
undetectable		 3si7C-3kipA:
20.65
3si7D-3kipA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3kip 3-DEHYDROQUINASE,
TYPE II
(Candida
albicans) 		4 / 7 ILE A 100
GLY A 131
ALA A 137
GLN A 109
 None
 0.93A 4g0uB-3kipA:
2.5		 4g0uB-3kipA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3kip 3-DEHYDROQUINASE,
TYPE II
(Candida
albicans) 		3 / 3 ALA A 138
TYR A 141
PRO A  98
 None
 0.53A 4zdyA-3kipA:
undetectable		 4zdyA-3kipA:
15.69