SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kiz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 6 CYH A  36
ASP A  92
VAL A  96
HIS A  54
 ACT  A 396 ( 4.6A)
ACT  A 396 (-3.8A)
None
ACT  A 396 (-4.4A)
 1.44A 1ekjG-3kizA:
undetectable
1ekjH-3kizA:
undetectable		 1ekjG-3kizA:
20.00
1ekjH-3kizA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.88A 1hsgB-3kizA:
undetectable		 1hsgB-3kizA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 11 LEU A  64
ALA A 212
LEU A 320
ALA A 256
LEU A 317
 None
 1.23A 1ictA-3kizA:
undetectable
1ictC-3kizA:
undetectable		 1ictA-3kizA:
16.92
1ictC-3kizA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 7 ASP A  84
LEU A 317
SER A 289
ASN A 337
 None
None
ACT  A 396 ( 4.6A)
None
 1.01A 1ig3A-3kizA:
undetectable
1ig3B-3kizA:
undetectable		 1ig3A-3kizA:
20.79
1ig3B-3kizA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 346
GLY A 284
ILE A 344
VAL A 285
 None
 0.88A 1rxcB-3kizA:
undetectable		 1rxcB-3kizA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 346
GLY A 284
ILE A 344
VAL A 285
 None
 0.92A 1rxcE-3kizA:
undetectable		 1rxcE-3kizA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 346
GLY A 284
ILE A 344
VAL A 285
 None
 0.92A 1rxcI-3kizA:
undetectable		 1rxcI-3kizA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 346
GLY A 284
ILE A 344
VAL A 285
 None
 0.88A 1rxcK-3kizA:
undetectable		 1rxcK-3kizA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.94A 1sduB-3kizA:
undetectable		 1sduB-3kizA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 11 LEU A  64
LEU A 261
SER A 262
LEU A 320
LEU A 259
 None
 1.24A 1tz8A-3kizA:
undetectable
1tz8B-3kizA:
undetectable		 1tz8A-3kizA:
16.92
1tz8B-3kizA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 11 LEU A 320
LEU A 259
LEU A  64
LEU A 261
SER A 262
 None
 1.23A 1tz8A-3kizA:
undetectable
1tz8B-3kizA:
undetectable		 1tz8A-3kizA:
16.92
1tz8B-3kizA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.89A 2avvE-3kizA:
undetectable		 2avvE-3kizA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.78A 2bpxB-3kizA:
undetectable		 2bpxB-3kizA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 10 ILE A 357
ALA A 358
ILE A  94
GLU A 273
ILE A 275
 None
None
None
None
EDO  A 397 ( 4.8A)
 1.24A 2dm6A-3kizA:
undetectable
2dm6B-3kizA:
undetectable		 2dm6A-3kizA:
20.00
2dm6B-3kizA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 6 LEU A 380
TYR A 392
ILE A 382
GLY A 291
 None
 0.88A 2du8A-3kizA:
undetectable		 2du8A-3kizA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 6 LEU A 380
TYR A 392
ILE A 382
GLY A 291
 None
 0.89A 2du8B-3kizA:
undetectable		 2du8B-3kizA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 11 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.91A 2fxeB-3kizA:
undetectable		 2fxeB-3kizA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 123
ILE A 108
ILE A  81
 EDO  A 398 ( 3.8A)
None
None
ACT  A 394 ( 4.6A)
None
 0.80A 2hs1A-3kizA:
undetectable		 2hs1A-3kizA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.81A 2o4lB-3kizA:
undetectable		 2o4lB-3kizA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.83A 2q63A-3kizA:
undetectable		 2q63A-3kizA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		3 / 3 GLY A  57
ASP A  56
SER A 162
 None
EDO  A 398 (-2.8A)
None
 0.59A 2qhfA-3kizA:
undetectable		 2qhfA-3kizA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 11 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.88A 2r5qB-3kizA:
undetectable		 2r5qB-3kizA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.82A 3d1xA-3kizA:
undetectable		 3d1xA-3kizA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 11 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.95A 3em4A-3kizA:
undetectable		 3em4A-3kizA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.85A 3jvyB-3kizA:
undetectable		 3jvyB-3kizA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.79A 3jw2B-3kizA:
undetectable		 3jw2B-3kizA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.88A 3k4vD-3kizA:
undetectable		 3k4vD-3kizA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.90A 3nduA-3kizA:
undetectable		 3nduA-3kizA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.85A 3nduB-3kizA:
undetectable		 3nduB-3kizA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.86A 3nduD-3kizA:
undetectable		 3nduD-3kizA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.84A 3oxcA-3kizA:
undetectable		 3oxcA-3kizA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.90A 3tkgA-3kizA:
undetectable		 3tkgA-3kizA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.91A 3tkgC-3kizA:
undetectable		 3tkgC-3kizA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 346
GLY A 284
ILE A 344
VAL A 285
 None
 0.95A 4e1vA-3kizA:
undetectable		 4e1vA-3kizA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 346
GLY A 284
ILE A 344
VAL A 285
 None
 0.94A 4e1vC-3kizA:
undetectable		 4e1vC-3kizA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 346
GLY A 284
ILE A 344
VAL A 285
 None
 0.92A 4e1vD-3kizA:
undetectable		 4e1vD-3kizA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 346
GLY A 284
ILE A 344
VAL A 285
 None
 0.92A 4e1vE-3kizA:
undetectable		 4e1vE-3kizA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 346
GLY A 284
ILE A 344
VAL A 285
 None
 1.00A 4e1vG-3kizA:
undetectable		 4e1vG-3kizA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 346
GLY A 284
ILE A 344
VAL A 285
 None
 0.94A 4e1vH-3kizA:
undetectable		 4e1vH-3kizA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.82A 4jecA-3kizA:
undetectable		 4jecA-3kizA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 ASN A 183
VAL A 184
ALA A 351
GLY A 280
ASP A 283
 None
None
None
EDO  A 397 (-3.3A)
None
 1.19A 4qckA-3kizA:
undetectable		 4qckA-3kizA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 10 GLY A 241
GLU A 242
GLN A 324
PHE A 217
ALA A 256
 None
 1.23A 4wnuD-3kizA:
undetectable		 4wnuD-3kizA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A 203
SER A 262
SER A 206
ASN A 201
 None
None
EDO  A 398 (-4.9A)
None
 1.03A 4ws1A-3kizA:
undetectable		 4ws1A-3kizA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 VAL A 216
ALA A 256
LEU A 221
SER A 228
ILE A  81
 None
 1.23A 5hv1A-3kizA:
undetectable		 5hv1A-3kizA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 TYR A 239
THR A 210
THR A  60
PRO A 231
 None
 1.13A 5jhdE-3kizA:
undetectable
5jhdG-3kizA:
undetectable		 5jhdE-3kizA:
23.47
5jhdG-3kizA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  59
ASP A 161
ILE A 108
VAL A  77
ILE A  81
 EDO  A 398 ( 3.8A)
None
ACT  A 394 ( 4.6A)
None
None
 0.86A 5kqxA-3kizA:
undetectable		 5kqxA-3kizA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 LEU A 254
ASP A 255
PHE A 217
LEU A 209
LEU A  64
 None
 1.11A 5tudA-3kizA:
undetectable		 5tudA-3kizA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		5 / 12 ALA A  65
GLY A 257
ILE A 158
ASP A 161
GLY A  57
 None
 1.21A 5wwsB-3kizA:
undetectable		 5wwsB-3kizA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Cytophaga
hutchinsonii) 		4 / 8 VAL A 335
HIS A 298
TYR A 392
GLU A 343
 None
 1.23A 6gneB-3kizA:
undetectable		 6gneB-3kizA:
22.14