SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kjr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 7 HIS A 226
LEU A 272
THR A 273
THR A 274
 None
 0.59A 1am6A-3kjrA:
undetectable		 1am6A-3kjrA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
THR A  69
LEU A  80
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
 0.90A 1ao8A-3kjrA:
19.2		 1ao8A-3kjrA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
THR A  69
SER A  72
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
 0.59A 1ao8A-3kjrA:
19.2		 1ao8A-3kjrA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 LYS A 275
ILE A 306
LEU A 390
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.9A)
None
None
None
None
None
None
 0.64A 1axwA-3kjrA:
38.2		 1axwA-3kjrA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 LYS A 275
ILE A 306
TRP A 307
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.68A 1axwB-3kjrA:
37.9		 1axwB-3kjrA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 ALA A 278
ILE A 306
TRP A 307
LEU A 390
ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.60A 1b02A-3kjrA:
34.9		 1b02A-3kjrA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
THR A  69
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
 0.40A 1cd2A-3kjrA:
22.7		 1cd2A-3kjrA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
ARG A  42
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.93A 1d1gA-3kjrA:
17.7		 1d1gA-3kjrA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.64A 1d1gA-3kjrA:
17.7		 1d1gA-3kjrA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ARG A  42
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.58A 1d1gB-3kjrA:
17.7		 1d1gB-3kjrA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.73A 1d1gB-3kjrA:
17.7		 1d1gB-3kjrA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
 0.68A 1ddrA-3kjrA:
19.8		 1ddrA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
THR A  69
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
 0.67A 1ddrA-3kjrA:
19.8		 1ddrA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
THR A  69
SER A  72
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
 0.79A 1ddrA-3kjrA:
19.8		 1ddrA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.68A 1ddrB-3kjrA:
20.0		 1ddrB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.34A 1ddrB-3kjrA:
20.0		 1ddrB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.69A 1ddsA-3kjrA:
20.3		 1ddsA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.59A 1ddsA-3kjrA:
20.3		 1ddsA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.64A 1ddsB-3kjrA:
20.2		 1ddsB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
SER A  72
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.53A 1ddsB-3kjrA:
20.2		 1ddsB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ILE A  29
ASP A  37
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
None
 0.44A 1df7A-3kjrA:
20.3		 1df7A-3kjrA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 11 ALA A  16
ILE A  29
ASP A  37
SER A  72
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
NAP  A 512 ( 4.2A)
None
 0.74A 1dg5A-3kjrA:
20.4		 1dg5A-3kjrA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 11 ALA A  16
ILE A  29
SER A  72
PRO A  74
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
NAP  A 512 ( 4.2A)
None
None
 0.78A 1dg5A-3kjrA:
20.4		 1dg5A-3kjrA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.61A 1dhfA-3kjrA:
22.9		 1dhfA-3kjrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
PRO A  74
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.91A 1dhfA-3kjrA:
22.9		 1dhfA-3kjrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.72A 1dhfB-3kjrA:
23.0		 1dhfB-3kjrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.77A 1dhiA-3kjrA:
20.3		 1dhiA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
SER A  72
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
None
 0.79A 1dhiA-3kjrA:
20.3		 1dhiA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 11 ALA A  16
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.71A 1dhiB-3kjrA:
20.5		 1dhiB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 11 ALA A  16
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.44A 1dhiB-3kjrA:
20.5		 1dhiB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.81A 1dhjA-3kjrA:
20.2		 1dhjA-3kjrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
SER A  72
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
None
 0.80A 1dhjA-3kjrA:
20.2		 1dhjA-3kjrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.88A 1dhjB-3kjrA:
20.4		 1dhjB-3kjrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.49A 1dhjB-3kjrA:
20.4		 1dhjB-3kjrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
SER A  72
ILE A  73
PRO A  74
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
None
None
 0.87A 1dlsA-3kjrA:
22.8		 1dlsA-3kjrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
SER A  72
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.86A 1draA-3kjrA:
20.2		 1draA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.73A 1draB-3kjrA:
20.5		 1draB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.46A 1draB-3kjrA:
20.5		 1draB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.83A 1drbA-3kjrA:
20.1		 1drbA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.49A 1drbA-3kjrA:
20.1		 1drbA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
SER A  72
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.86A 1drbA-3kjrA:
20.1		 1drbA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.78A 1drbB-3kjrA:
20.5		 1drbB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.49A 1drbB-3kjrA:
20.5		 1drbB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.76A 1dreA-3kjrA:
21.0		 1dreA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
SER A  72
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.68A 1drfA-3kjrA:
22.2		 1drfA-3kjrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 SER A  72
ILE A  73
PRO A  74
LEU A  80
TYR A 129
 NAP  A 512 ( 4.2A)
None
None
None
None
 0.77A 1drfA-3kjrA:
22.2		 1drfA-3kjrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.64A 1dyiA-3kjrA:
20.3		 1dyiA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.56A 1dyiB-3kjrA:
20.4		 1dyiB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 11 LEU A 128
VAL A 132
ILE A 141
VAL A  15
PHE A 156
 NAP  A 512 (-4.4A)
None
None
NAP  A 512 (-3.9A)
None
 1.16A 1gx9A-3kjrA:
undetectable		 1gx9A-3kjrA:
17.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 GLU A 285
ILE A 306
TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
 0.74A 1hvyA-3kjrA:
12.7		 1hvyA-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ILE A 306
TRP A 307
ASN A 310
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
 0.98A 1hvyA-3kjrA:
12.7		 1hvyA-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
TYR A 456
MET A 509
 GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.82A 1hvyA-3kjrA:
12.7		 1hvyA-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 GLU A 285
ASN A 310
ASP A 416
LEU A 419
GLY A 420
TYR A 456
MET A 509
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.7A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.78A 1hvyB-3kjrA:
44.3		 1hvyB-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 GLU A 285
ASN A 310
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.7A)
None
None
None
None
GOL  A 516 (-4.0A)
 1.01A 1hvyB-3kjrA:
44.3		 1hvyB-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 GLU A 285
ILE A 306
ASN A 310
ASP A 416
LEU A 419
GLY A 420
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
 0.69A 1hvyB-3kjrA:
44.3		 1hvyB-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 GLU A 285
ILE A 306
ASN A 310
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
 0.85A 1hvyB-3kjrA:
44.3		 1hvyB-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 GLU A 285
ILE A 306
TRP A 307
ASN A 310
ASP A 416
GLY A 420
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
 0.72A 1hvyB-3kjrA:
44.3		 1hvyB-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 GLU A 285
ILE A 306
TRP A 307
ASN A 310
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
 0.88A 1hvyB-3kjrA:
44.3		 1hvyB-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 GLU A 285
TRP A 307
ASN A 310
ASP A 416
GLY A 420
TYR A 456
MET A 509
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
GOL  A 516 (-4.0A)
 0.81A 1hvyB-3kjrA:
44.3		 1hvyB-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 GLU A 285
TRP A 307
ASN A 310
GLY A 420
PHE A 423
TYR A 456
MET A 509
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
GOL  A 516 (-4.0A)
 1.05A 1hvyB-3kjrA:
44.3		 1hvyB-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 GLU A 285
ILE A 306
TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
MET A 509
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
GOL  A 516 (-4.0A)
 0.88A 1hvyC-3kjrA:
12.7		 1hvyC-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 GLU A 285
ILE A 306
TRP A 307
ASP A 416
LEU A 419
GLY A 420
TYR A 456
MET A 509
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.81A 1hvyC-3kjrA:
12.7		 1hvyC-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ILE A 306
ASN A 310
LEU A 419
GLY A 420
PHE A 423
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
GOL  A 516 (-4.0A)
 1.11A 1hvyC-3kjrA:
12.7		 1hvyC-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ILE A 306
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 GOL  A 516 (-3.9A)
None
None
None
None
GOL  A 516 (-4.0A)
 1.01A 1hvyC-3kjrA:
12.7		 1hvyC-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ASN A 310
LEU A 390
ASP A 416
GLY A 420
PHE A 423
TYR A 456
MET A 509
 GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 1.19A 1hvyD-3kjrA:
44.3		 1hvyD-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 12 GLU A 285
ILE A 306
TRP A 307
ASN A 310
LEU A 390
ASP A 416
LEU A 419
GLY A 420
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.78A 1hvyD-3kjrA:
44.3		 1hvyD-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 12 GLU A 285
TRP A 307
ASN A 310
LEU A 390
ASP A 416
LEU A 419
GLY A 420
TYR A 456
MET A 509
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.85A 1hvyD-3kjrA:
44.3		 1hvyD-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ILE A 306
ASN A 310
LEU A 390
ASP A 416
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 1.02A 1hvyD-3kjrA:
44.3		 1hvyD-3kjrA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 9 GLU A 285
ILE A 306
ASP A 416
LEU A 419
GLY A 420
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
None
None
None
None
 0.76A 1i00A-3kjrA:
12.2		 1i00A-3kjrA:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 9 GLU A 285
ILE A 306
TRP A 307
LEU A 419
GLY A 420
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
 0.57A 1i00A-3kjrA:
12.2		 1i00A-3kjrA:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 9 ILE A 306
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.9A)
None
None
None
None
 1.03A 1i00A-3kjrA:
12.2		 1i00A-3kjrA:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 9 ILE A 306
TRP A 307
LEU A 419
GLY A 420
PHE A 423
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
 0.98A 1i00A-3kjrA:
12.2		 1i00A-3kjrA:
32.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 10 ALA A  16
ASP A  37
SER A  72
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.40A 1j3jA-3kjrA:
23.3		 1j3jA-3kjrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 9 ALA A  16
ASP A  37
SER A  72
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.33A 1j3jB-3kjrA:
23.1		 1j3jB-3kjrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.74A 1jolA-3kjrA:
20.3		 1jolA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.70A 1jolB-3kjrA:
20.5		 1jolB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 11 ALA A  16
ASP A  37
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
None
 0.64A 1jomA-3kjrA:
19.9		 1jomA-3kjrA:
16.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 11 ILE A 306
TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.53A 1ju6A-3kjrA:
44.6		 1ju6A-3kjrA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 9 LYS A 275
ILE A 306
TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
TYR A 456
MET A 509
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.50A 1ju6B-3kjrA:
44.6		 1ju6B-3kjrA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 10 ILE A 306
TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.54A 1ju6C-3kjrA:
44.6		 1ju6C-3kjrA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 11 LYS A 275
ILE A 306
TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
TYR A 456
MET A 509
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.50A 1ju6D-3kjrA:
44.6		 1ju6D-3kjrA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		10 / 10 LYS A 275
ILE A 306
TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.55A 1jujA-3kjrA:
43.5		 1jujA-3kjrA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		10 / 10 LYS A 275
ILE A 306
TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.55A 1jujB-3kjrA:
43.4		 1jujB-3kjrA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		10 / 10 LYS A 275
ILE A 306
TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.55A 1jujC-3kjrA:
43.4		 1jujC-3kjrA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		10 / 10 LYS A 275
ILE A 306
TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.55A 1jujD-3kjrA:
43.4		 1jujD-3kjrA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.47A 1qzfA-3kjrA:
43.9		 1qzfA-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.48A 1qzfB-3kjrA:
43.9		 1qzfB-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.48A 1qzfC-3kjrA:
43.9		 1qzfC-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.49A 1qzfD-3kjrA:
43.9		 1qzfD-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.50A 1qzfE-3kjrA:
43.9		 1qzfE-3kjrA:
46.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.57A 1ra2A-3kjrA:
20.5		 1ra2A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.67A 1ra3A-3kjrA:
20.4		 1ra3A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.31A 1ra3A-3kjrA:
20.4		 1ra3A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.58A 1ra8A-3kjrA:
20.4		 1ra8A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.59A 1rb2A-3kjrA:
20.6		 1rb2A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.35A 1rb2B-3kjrA:
20.5		 1rb2B-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 10 ALA A  16
ASP A  37
ILE A  73
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.70A 1rb3A-3kjrA:
20.5		 1rb3A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
None
None
 0.75A 1rb3B-3kjrA:
20.6		 1rb3B-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.61A 1rd7A-3kjrA:
19.8		 1rd7A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.55A 1rd7B-3kjrA:
19.7		 1rd7B-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
 0.37A 1re7A-3kjrA:
20.1		 1re7A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.59A 1re7B-3kjrA:
19.9		 1re7B-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
SER A  72
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
None
 0.85A 1rg7A-3kjrA:
18.9		 1rg7A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
SER A  72
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
None
 0.73A 1rg7A-3kjrA:
18.9		 1rg7A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ASP A  37
SER A  72
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.77A 1rh3A-3kjrA:
21.0		 1rh3A-3kjrA:
16.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 8 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.67A 1rtsA-3kjrA:
41.3		 1rtsA-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 7 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.47A 1rtsB-3kjrA:
42.1		 1rtsB-3kjrA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.56A 1rx2A-3kjrA:
21.3		 1rx2A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.63A 1rx3A-3kjrA:
21.2		 1rx3A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.50A 1rx7A-3kjrA:
19.5		 1rx7A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.56A 1rx8A-3kjrA:
20.9		 1rx8A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
 0.79A 1tdrA-3kjrA:
20.2		 1tdrA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
THR A  69
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
 0.63A 1tdrA-3kjrA:
20.2		 1tdrA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 10 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.78A 1tdrB-3kjrA:
20.5		 1tdrB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 10 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.39A 1tdrB-3kjrA:
20.5		 1tdrB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 SER A 281
ILE A 306
TRP A 307
LEU A 390
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.64A 1tlsA-3kjrA:
38.6		 1tlsA-3kjrA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 SER A 281
ILE A 306
TRP A 307
LEU A 390
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.71A 1tlsB-3kjrA:
38.7		 1tlsB-3kjrA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 SER A 281
ILE A 306
TRP A 307
LEU A 390
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.68A 1tsnA-3kjrA:
38.6		 1tsnA-3kjrA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
PRO A  74
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
None
None
None
 0.78A 1u70A-3kjrA:
22.8		 1u70A-3kjrA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
SER A  72
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.62A 1u72A-3kjrA:
22.6		 1u72A-3kjrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 TYR A 456
ALA A 511
SER A 510
ASN A 247
 None
 1.20A 1yvpB-3kjrA:
undetectable		 1yvpB-3kjrA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 11 ILE A 120
ASP A  10
TYR A   5
GLY A   7
LEU A 104
 None
None
None
None
NAP  A 512 (-4.8A)
 1.20A 2azyA-3kjrA:
undetectable		 2azyA-3kjrA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.38A 2bl9A-3kjrA:
23.4		 2bl9A-3kjrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
SER A  72
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.63A 2blaA-3kjrA:
22.8		 2blaA-3kjrA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.42A 2cd2A-3kjrA:
22.8		 2cd2A-3kjrA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 THR A  69
PRO A  74
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.6A)
None
None
None
None
 0.85A 2cd2A-3kjrA:
22.8		 2cd2A-3kjrA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.57A 2d0kA-3kjrA:
19.9		 2d0kA-3kjrA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.71A 2d0kB-3kjrA:
20.1		 2d0kB-3kjrA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
None
None
None
None
 0.75A 2drcA-3kjrA:
20.2		 2drcA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
SER A  72
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.77A 2drcA-3kjrA:
20.2		 2drcA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.69A 2drcB-3kjrA:
20.4		 2drcB-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.37A 2drcB-3kjrA:
20.4		 2drcB-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 SER A 281
GLU A 285
TRP A 307
LEU A 390
ASP A 416
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.74A 2kceA-3kjrA:
38.6		 2kceA-3kjrA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 SER A 281
TRP A 307
LEU A 390
ASP A 416
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.87A 2kceB-3kjrA:
38.4		 2kceB-3kjrA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 SER A 281
TRP A 307
LEU A 390
ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.69A 2kceB-3kjrA:
38.4		 2kceB-3kjrA:
26.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.49A 2oipA-3kjrA:
43.7		 2oipA-3kjrA:
46.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.31A 2oipB-3kjrA:
13.1		 2oipB-3kjrA:
46.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.37A 2oipC-3kjrA:
45.3		 2oipC-3kjrA:
46.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.49A 2oipD-3kjrA:
43.0		 2oipD-3kjrA:
46.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.49A 2oipE-3kjrA:
44.0		 2oipE-3kjrA:
46.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
None
None
None
 0.80A 2qk8A-3kjrA:
20.1		 2qk8A-3kjrA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 8 GLN A 230
ASP A 264
LEU A 265
GLY A 444
 None
 0.81A 2qqcH-3kjrA:
undetectable
2qqcK-3kjrA:
undetectable		 2qqcH-3kjrA:
13.26
2qqcK-3kjrA:
6.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 7 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.61A 2tsrA-3kjrA:
40.9		 2tsrA-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 GLU A 285
ILE A 306
TRP A 307
LEU A 419
GLY A 420
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
 0.85A 2tsrC-3kjrA:
40.8		 2tsrC-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 9 ILE A 306
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.9A)
None
None
None
None
 1.05A 2tsrD-3kjrA:
12.3		 2tsrD-3kjrA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 11 ALA A  16
PHE A  38
THR A  69
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
 0.71A 2w3aA-3kjrA:
23.2		 2w3aA-3kjrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
THR A  69
ILE A  73
PRO A  74
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.48A 2w3aA-3kjrA:
23.2		 2w3aA-3kjrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 10 ALA A  16
PHE A  38
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.56A 2w3aB-3kjrA:
23.1		 2w3aB-3kjrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ARG A  39
THR A  69
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
 1.13A 2w3bA-3kjrA:
23.0		 2w3bA-3kjrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
THR A  69
ILE A  73
PRO A  74
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.80A 2w3bA-3kjrA:
23.0		 2w3bA-3kjrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ILE A  73
PRO A  74
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.79A 2w3bB-3kjrA:
23.0		 2w3bB-3kjrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ILE A  73
PRO A  74
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.76A 2w3mA-3kjrA:
23.1		 2w3mA-3kjrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.37A 2w3mB-3kjrA:
23.0		 2w3mB-3kjrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 1.11A 2w3vA-3kjrA:
20.8		 2w3vA-3kjrA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ILE A  29
ASP A  37
SER A  72
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
NAP  A 512 ( 4.2A)
None
None
 0.66A 2w3vA-3kjrA:
20.8		 2w3vA-3kjrA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A  16
ASP A  37
SER A  72
ILE A  73
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
 0.85A 2w9gA-3kjrA:
20.7		 2w9gA-3kjrA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
SER A  72
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.81A 2w9sA-3kjrA:
20.8		 2w9sA-3kjrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
SER A  72
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.81A 2w9sB-3kjrA:
20.9		 2w9sB-3kjrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 10 ALA A  16
ASP A  37
SER A  72
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.81A 2w9sC-3kjrA:
20.9		 2w9sC-3kjrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A  16
ASP A  37
SER A  72
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
 0.27A 2w9sD-3kjrA:
20.4		 2w9sD-3kjrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 8 ALA A  16
ASP A  37
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
 0.20A 2w9sE-3kjrA:
20.4		 2w9sE-3kjrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A  16
ASP A  37
SER A  72
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
 0.27A 2w9sF-3kjrA:
20.3		 2w9sF-3kjrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.70A 2zzaA-3kjrA:
20.9		 2zzaA-3kjrA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.72A 2zzaB-3kjrA:
20.9		 2zzaB-3kjrA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 11 ILE A 108
LEU A 123
LEU A  11
ILE A 122
LEU A  88
 None
None
None
None
NAP  A 512 (-4.4A)
 1.16A 3a50C-3kjrA:
undetectable		 3a50C-3kjrA:
22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
ILE A  29
ASP A  37
THR A  69
SER A  72
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
None
 0.82A 3cl9A-3kjrA:
18.1		 3cl9A-3kjrA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
ILE A  29
THR A  69
SER A  72
PRO A  74
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
None
None
 1.02A 3cl9A-3kjrA:
18.1		 3cl9A-3kjrA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLB_A_TMQA611_1
(DHFR-TS)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 ALA A  16
ILE A  29
ASP A  37
ILE A  73
PRO A  74
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
None
None
None
 0.61A 3clbA-3kjrA:
12.7		 3clbA-3kjrA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLB_B_TMQB612_1
(DHFR-TS)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
ILE A  29
ASP A  37
THR A  69
SER A  72
ILE A  73
PRO A  74
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
None
 0.78A 3clbB-3kjrA:
20.3		 3clbB-3kjrA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLB_C_TMQC613_1
(DHFR-TS)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 12 ALA A  16
ILE A  29
ASP A  37
THR A  69
ILE A  73
PRO A  74
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.66A 3clbC-3kjrA:
39.1		 3clbC-3kjrA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLB_D_TMQD614_1
(DHFR-TS)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 10 ALA A  16
ILE A  29
ASP A  37
ILE A  73
PRO A  74
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
None
None
 0.70A 3clbD-3kjrA:
16.5		 3clbD-3kjrA:
39.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
None
None
None
 0.73A 3datA-3kjrA:
20.6		 3datA-3kjrA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
None
None
None
None
 0.70A 3dauA-3kjrA:
21.0		 3dauA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
None
None
None
 0.39A 3dauA-3kjrA:
21.0		 3dauA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.39A 3dfrA-3kjrA:
21.2		 3dfrA-3kjrA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
None
None
None
None
 0.77A 3drcA-3kjrA:
20.2		 3drcA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
SER A  72
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.78A 3drcA-3kjrA:
20.2		 3drcA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.69A 3drcB-3kjrA:
20.5		 3drcB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.38A 3drcB-3kjrA:
20.5		 3drcB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
SER A  72
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.70A 3eigA-3kjrA:
22.1		 3eigA-3kjrA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
SER A  72
PRO A  74
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.92A 3eigA-3kjrA:
22.1		 3eigA-3kjrA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 5 ASP A 492
ARG A 280
ILE A 283
VAL A 496
 None
 1.19A 3eigA-3kjrA:
22.1		 3eigA-3kjrA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
SER A  72
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.81A 3frbX-3kjrA:
20.6		 3frbX-3kjrA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 9 ALA A  16
ASP A  37
SER A  72
ILE A  73
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
 0.84A 3freX-3kjrA:
20.6		 3freX-3kjrA:
15.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 10 ALA A  16
ILE A  29
ASP A  37
ILE A  73
PRO A  74
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
None
None
 0.63A 3hbbA-3kjrA:
12.7		 3hbbA-3kjrA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 9 ALA A  16
ILE A  29
ASP A  37
THR A  69
SER A  72
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
 0.71A 3hbbB-3kjrA:
12.2		 3hbbB-3kjrA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 ALA A  16
ILE A  29
ASP A  37
ILE A  73
PRO A  74
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
None
None
None
 0.67A 3hbbC-3kjrA:
39.1		 3hbbC-3kjrA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 10 ALA A  16
ILE A  29
ASP A  37
ILE A  73
PRO A  74
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
None
None
 0.69A 3hbbD-3kjrA:
13.9		 3hbbD-3kjrA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.59A 3hj3A-3kjrA:
45.2		 3hj3A-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.58A 3hj3B-3kjrA:
45.2		 3hj3B-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.45A 3hj3C-3kjrA:
45.0		 3hj3C-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.56A 3hj3D-3kjrA:
43.2		 3hj3D-3kjrA:
46.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
SER A  72
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.86A 3ia4A-3kjrA:
20.8		 3ia4A-3kjrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
SER A  72
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.56A 3ia4A-3kjrA:
20.8		 3ia4A-3kjrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
SER A  72
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
None
 0.89A 3ia4B-3kjrA:
20.9		 3ia4B-3kjrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
SER A  72
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.85A 3ia4C-3kjrA:
21.0		 3ia4C-3kjrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
SER A  72
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.58A 3ia4C-3kjrA:
21.0		 3ia4C-3kjrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
SER A  72
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
None
 0.87A 3ia4D-3kjrA:
20.9		 3ia4D-3kjrA:
15.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		12 / 12 ALA A 278
SER A 281
GLU A 285
ILE A 306
TRP A 307
LEU A 390
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 None
None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.42A 3k2hA-3kjrA:
52.9		 3k2hA-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
ASP A  37
LEU A  41
THR A  69
LEU A  80
ARG A  83
LEU A 123
TYR A 129
 NAP  A 512 (-3.7A)
None
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.31A 3k2hA-3kjrA:
52.9		 3k2hA-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
LEU A  41
THR A  69
ILE A  73
LEU A  80
ARG A  83
LEU A 123
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.65A 3k2hA-3kjrA:
52.9		 3k2hA-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 LEU A  41
ARG A  42
THR A  69
ILE A  73
LEU A  80
ARG A  83
LEU A 123
TYR A 129
 None
None
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.88A 3k2hA-3kjrA:
52.9		 3k2hA-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 THR A  69
ILE A  73
SER A  77
LEU A  80
TYR A 129
 NAP  A 512 (-3.6A)
None
None
None
None
 0.84A 3k2hA-3kjrA:
52.9		 3k2hA-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		12 / 12 ALA A 278
SER A 281
GLU A 285
ILE A 306
TRP A 307
LEU A 390
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 None
None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.40A 3k2hB-3kjrA:
52.6		 3k2hB-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ILE A  29
ASP A  37
LEU A  41
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
None
None
 0.51A 3k2hB-3kjrA:
52.6		 3k2hB-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ILE A  29
ILE A  73
SER A  77
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
None
 1.22A 3k2hB-3kjrA:
52.6		 3k2hB-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ILE A  29
LEU A  41
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
None
None
 0.85A 3k2hB-3kjrA:
52.6		 3k2hB-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 LEU A  41
SER A  72
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.78A 3k2hB-3kjrA:
52.6		 3k2hB-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 SER A  72
ILE A  73
SER A  77
LEU A  80
TYR A 129
 NAP  A 512 ( 4.2A)
None
None
None
None
 0.79A 3k2hB-3kjrA:
52.6		 3k2hB-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		3 / 3 ARG A  42
THR A  69
THR A 144
 None
NAP  A 512 (-3.6A)
None
 0.61A 3k2hB-3kjrA:
52.6		 3k2hB-3kjrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		3 / 3 SER A 407
GLY A 444
SER A 402
 None
 0.53A 3loqA-3kjrA:
undetectable		 3loqA-3kjrA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 8 ILE A  34
PHE A 181
THR A 171
VAL A 177
 None
 0.82A 3me6B-3kjrA:
undetectable		 3me6B-3kjrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.60A 3n0hA-3kjrA:
23.0		 3n0hA-3kjrA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 12 PHE A  14
ALA A  16
ASP A  37
LEU A  41
THR A  69
ILE A  73
SER A  77
LEU A 123
THR A 144
 None
NAP  A 512 (-3.7A)
None
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.60A 3nrrA-3kjrA:
52.1		 3nrrA-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 12 PHE A  14
ALA A  16
LEU A  41
THR A  69
ILE A  73
PRO A  74
SER A  77
LEU A 123
THR A 144
 None
NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.71A 3nrrA-3kjrA:
52.1		 3nrrA-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		12 / 12 ALA A 278
SER A 281
GLU A 285
ILE A 306
TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 None
None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.63A 3nrrA-3kjrA:
52.1		 3nrrA-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
ASP A  37
LEU A  41
THR A  69
ILE A  73
SER A  77
LEU A 123
THR A 144
 NAP  A 512 (-3.7A)
None
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.65A 3nrrB-3kjrA:
52.4		 3nrrB-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
HIS A  33
ASP A  37
LEU A  41
THR A  69
LEU A 123
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
NAP  A 512 (-3.6A)
None
None
 0.60A 3nrrB-3kjrA:
52.4		 3nrrB-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ALA A  16
LEU A  41
THR A  69
ILE A  73
PRO A  74
SER A  77
LEU A 123
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.75A 3nrrB-3kjrA:
52.4		 3nrrB-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		11 / 12 ALA A 278
SER A 281
GLU A 285
ILE A 306
ASN A 310
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 None
None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.60A 3nrrB-3kjrA:
52.4		 3nrrB-3kjrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		11 / 12 ALA A 278
SER A 281
GLU A 285
ILE A 306
TRP A 307
ASN A 310
ASP A 416
GLY A 420
PHE A 423
TYR A 456
MET A 509
 None
None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.61A 3nrrB-3kjrA:
52.4		 3nrrB-3kjrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 HIS A 459
ASP A 458
THR A 251
LEU A 419
GLY A 420
 None
 1.47A 3ondA-3kjrA:
undetectable		 3ondA-3kjrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 1.07A 3qfxA-3kjrA:
21.6		 3qfxA-3kjrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ILE A  29
ASP A  37
THR A  69
SER A  72
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
 0.42A 3qfxA-3kjrA:
21.6		 3qfxA-3kjrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 1.06A 3qfxB-3kjrA:
21.7		 3qfxB-3kjrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ILE A  29
ASP A  37
THR A  69
SER A  72
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
 0.43A 3qfxB-3kjrA:
21.7		 3qfxB-3kjrA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 10 ALA A  16
ASP A  37
SER A  72
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.39A 3qg2A-3kjrA:
41.6		 3qg2A-3kjrA:
44.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 11 ALA A  16
ASP A  37
SER A  72
ILE A  73
LEU A 123
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.52A 3qg2B-3kjrA:
41.7		 3qg2B-3kjrA:
44.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 10 ALA A  16
ASP A  37
SER A  72
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.39A 3qgtA-3kjrA:
41.1		 3qgtA-3kjrA:
44.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A  16
ASP A  37
SER A  72
ILE A  73
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
 1.28A 3qgtB-3kjrA:
41.4		 3qgtB-3kjrA:
44.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 10 ALA A  16
ASP A  37
SER A  72
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.33A 3qgtB-3kjrA:
41.4		 3qgtB-3kjrA:
44.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.69A 3ql0A-3kjrA:
21.7		 3ql0A-3kjrA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.62A 3ql3A-3kjrA:
21.4		 3ql3A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.62A 3s3vA-3kjrA:
22.9		 3s3vA-3kjrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 7 THR A 251
ASN A 247
ASP A 458
HIS A 459
 None
 1.10A 3t01A-3kjrA:
undetectable		 3t01A-3kjrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 9 ALA A  16
ASP A  37
SER A  72
ILE A  73
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
 0.80A 3tq8A-3kjrA:
21.3		 3tq8A-3kjrA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
LEU A  80
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.81A 3tq9A-3kjrA:
20.9		 3tq9A-3kjrA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
SER A  72
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.62A 3tq9A-3kjrA:
20.9		 3tq9A-3kjrA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 11 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.71A 3tqbA-3kjrA:
20.9		 3tqbA-3kjrA:
17.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 10 ASP A  37
THR A  69
SER A  72
ILE A  73
TYR A 129
THR A 144
 None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
None
 0.33A 3um5A-3kjrA:
41.9		 3um5A-3kjrA:
44.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 10 ASP A  37
THR A  69
SER A  72
ILE A  73
TYR A 129
THR A 144
 None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
None
 0.36A 3um5B-3kjrA:
41.4		 3um5B-3kjrA:
44.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 12 ILE A 306
TRP A 307
LEU A 390
HIS A 394
LEU A 419
GLY A 420
PHE A 423
ASN A 424
TYR A 456
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
None
 0.60A 3uwlB-3kjrA:
39.4		 3uwlB-3kjrA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 TRP A 307
LEU A 390
HIS A 394
LEU A 419
GLY A 420
PHE A 423
ASN A 424
TYR A 456
 GOL  A 516 (-3.7A)
None
None
None
None
None
None
None
 0.59A 3uwlD-3kjrA:
38.4		 3uwlD-3kjrA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.60A 4cd2A-3kjrA:
20.9		 4cd2A-3kjrA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
 0.75A 4dfrA-3kjrA:
20.0		 4dfrA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
SER A  72
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
NAP  A 512 ( 4.2A)
None
None
None
 0.82A 4dfrA-3kjrA:
20.0		 4dfrA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.72A 4dfrB-3kjrA:
20.4		 4dfrB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.39A 4dfrB-3kjrA:
20.4		 4dfrB-3kjrA:
16.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ILE A 306
ASP A 416
LEU A 419
GLY A 420
TYR A 456
MET A 509
 GOL  A 516 (-3.9A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.70A 4eb4A-3kjrA:
43.6		 4eb4A-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ILE A 306
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 GOL  A 516 (-3.9A)
None
None
None
None
GOL  A 516 (-4.0A)
 1.01A 4eb4A-3kjrA:
43.6		 4eb4A-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ILE A 306
TRP A 307
ASP A 416
GLY A 420
ASN A 424
TYR A 456
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.81A 4eb4A-3kjrA:
43.6		 4eb4A-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ILE A 306
ASP A 416
LEU A 419
GLY A 420
TYR A 456
MET A 509
 GOL  A 516 (-3.9A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.68A 4eb4B-3kjrA:
43.5		 4eb4B-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ILE A 306
GLY A 420
PHE A 423
ASN A 424
TYR A 456
MET A 509
 GOL  A 516 (-3.9A)
None
None
None
None
GOL  A 516 (-4.0A)
 1.07A 4eb4B-3kjrA:
43.5		 4eb4B-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ILE A 306
LEU A 419
GLY A 420
PHE A 423
TYR A 456
MET A 509
 GOL  A 516 (-3.9A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.99A 4eb4B-3kjrA:
43.5		 4eb4B-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ILE A 306
TRP A 307
ASP A 416
GLY A 420
ASN A 424
TYR A 456
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.79A 4eb4B-3kjrA:
43.5		 4eb4B-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ASP A 416
LEU A 419
GLY A 420
ASN A 424
TYR A 456
 None
 0.69A 4eb4D-3kjrA:
41.8		 4eb4D-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.43A 4eckB-3kjrA:
44.4		 4eckB-3kjrA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 11 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.28A 4eilA-3kjrA:
45.9		 4eilA-3kjrA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.31A 4eilB-3kjrA:
46.7		 4eilB-3kjrA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 11 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.31A 4eilC-3kjrA:
45.9		 4eilC-3kjrA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 11 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.30A 4eilE-3kjrA:
45.9		 4eilE-3kjrA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 9 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.31A 4eilF-3kjrA:
46.7		 4eilF-3kjrA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.31A 4eilG-3kjrA:
45.9		 4eilG-3kjrA:
42.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
 0.68A 4ej1A-3kjrA:
19.9		 4ej1A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.61A 4ej1B-3kjrA:
19.8		 4ej1B-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 8 TYR A 231
LEU A 235
VAL A 238
TYR A 254
 None
 0.73A 4fgzB-3kjrA:
undetectable		 4fgzB-3kjrA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.72A 4fhbA-3kjrA:
20.6		 4fhbA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 11 LYS A 275
SER A 281
ILE A 306
TRP A 307
LEU A 390
ASP A 416
GLY A 420
PHE A 423
TYR A 456
 None
None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.58A 4fogA-3kjrA:
37.5		 4fogA-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 SER A 281
ILE A 306
TRP A 307
LEU A 390
ASP A 416
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.58A 4fogC-3kjrA:
38.2		 4fogC-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 11 LYS A 275
ILE A 306
TRP A 307
LEU A 390
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
 0.62A 4fogD-3kjrA:
38.7		 4fogD-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		10 / 12 SER A 281
GLU A 285
ILE A 306
TRP A 307
LEU A 390
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
 0.69A 4foxA-3kjrA:
37.7		 4foxA-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		10 / 12 SER A 281
GLU A 285
ILE A 306
TRP A 307
LEU A 390
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
 0.69A 4foxB-3kjrA:
37.9		 4foxB-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 11 SER A 281
GLU A 285
TRP A 307
LEU A 390
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
 0.71A 4foxC-3kjrA:
37.6		 4foxC-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 12 SER A 281
GLU A 285
ILE A 306
TRP A 307
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.54A 4foxD-3kjrA:
38.8		 4foxD-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		10 / 12 LYS A 275
SER A 281
GLU A 285
ILE A 306
TRP A 307
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 None
None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.55A 4foxE-3kjrA:
37.8		 4foxE-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 GLU A 285
ILE A 306
TRP A 307
LEU A 390
ASP A 416
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.63A 4foxF-3kjrA:
38.1		 4foxF-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		10 / 12 SER A 281
GLU A 285
ILE A 306
TRP A 307
LEU A 390
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
 0.67A 4foxG-3kjrA:
37.8		 4foxG-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 SER A 281
GLU A 285
ILE A 306
TRP A 307
ASP A 416
GLY A 420
PHE A 423
TYR A 456
 None
GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
 0.45A 4foxH-3kjrA:
37.9		 4foxH-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 GLU A 285
ILE A 306
TRP A 307
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.39A 4fqsA-3kjrA:
39.4		 4fqsA-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 GLU A 285
ILE A 306
TRP A 307
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.39A 4fqsB-3kjrA:
39.4		 4fqsB-3kjrA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 GLY A   9
PHE A 121
ILE A 122
ASN A 135
VAL A 132
 None
 1.08A 4fr0A-3kjrA:
undetectable		 4fr0A-3kjrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A  16
SER A  72
PRO A  74
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.61A 4g8zX-3kjrA:
22.7		 4g8zX-3kjrA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.66A 4gh8A-3kjrA:
22.0		 4gh8A-3kjrA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 SER A  72
ILE A  73
PRO A  74
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 ( 4.2A)
None
None
None
None
None
 0.85A 4gh8A-3kjrA:
22.0		 4gh8A-3kjrA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.65A 4gh8B-3kjrA:
21.8		 4gh8B-3kjrA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 SER A  72
ILE A  73
PRO A  74
ARG A  83
TYR A 129
 NAP  A 512 ( 4.2A)
None
None
None
None
 0.85A 4gh8B-3kjrA:
21.8		 4gh8B-3kjrA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
 0.68A 4i13A-3kjrA:
19.8		 4i13A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		3 / 3 ASP A  37
ARG A  83
THR A 144
 None
 0.19A 4i13A-3kjrA:
19.8		 4i13A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.47A 4i1nA-3kjrA:
19.7		 4i1nA-3kjrA:
16.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 7 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.72A 4iqqA-3kjrA:
40.0		 4iqqA-3kjrA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 7 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.70A 4iqqB-3kjrA:
38.8		 4iqqB-3kjrA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 7 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.60A 4iqqC-3kjrA:
39.1		 4iqqC-3kjrA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 8 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.64A 4iqqD-3kjrA:
38.6		 4iqqD-3kjrA:
35.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.54A 4kebB-3kjrA:
23.0		 4kebB-3kjrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ILE A  73
PRO A  74
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.80A 4kfjB-3kjrA:
23.3		 4kfjB-3kjrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
 0.68A 4kjjA-3kjrA:
20.1		 4kjjA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
 0.71A 4kjkA-3kjrA:
20.9		 4kjkA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.61A 4kjlA-3kjrA:
21.3		 4kjlA-3kjrA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A  16
ASP A  37
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 1.17A 4km0A-3kjrA:
19.3		 4km0A-3kjrA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A  16
ASP A  37
THR A  69
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
 0.60A 4km0A-3kjrA:
19.3		 4km0A-3kjrA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
THR A  69
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
 0.53A 4km0B-3kjrA:
19.7		 4km0B-3kjrA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  29
ASP A  37
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
 0.68A 4km0B-3kjrA:
19.7		 4km0B-3kjrA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
THR A  69
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
 0.67A 4km2A-3kjrA:
20.0		 4km2A-3kjrA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ILE A  29
ASP A  37
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
None
 0.66A 4km2A-3kjrA:
20.0		 4km2A-3kjrA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ILE A  29
ASP A  37
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
None
 0.61A 4km2B-3kjrA:
19.8		 4km2B-3kjrA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 5 MET A 261
LEU A 450
PRO A 270
SER A 429
 None
 1.15A 4kmmB-3kjrA:
undetectable		 4kmmB-3kjrA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.57A 4ky8A-3kjrA:
44.1		 4ky8A-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.60A 4ky8B-3kjrA:
43.8		 4ky8B-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.50A 4ky8C-3kjrA:
44.0		 4ky8C-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.72A 4ky8C-3kjrA:
44.0		 4ky8C-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.61A 4ky8D-3kjrA:
43.9		 4ky8D-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.65A 4ky8E-3kjrA:
44.3		 4ky8E-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
THR A  69
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
 0.43A 4kyaA-3kjrA:
45.7		 4kyaA-3kjrA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.35A 4kyaB-3kjrA:
46.5		 4kyaB-3kjrA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.40A 4kyaC-3kjrA:
44.8		 4kyaC-3kjrA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.34A 4kyaD-3kjrA:
45.4		 4kyaD-3kjrA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
THR A  69
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
 0.43A 4kyaE-3kjrA:
45.7		 4kyaE-3kjrA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.36A 4kyaF-3kjrA:
46.5		 4kyaF-3kjrA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
THR A  69
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
 0.44A 4kyaG-3kjrA:
45.7		 4kyaG-3kjrA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.35A 4kyaH-3kjrA:
46.6		 4kyaH-3kjrA:
42.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  29
ASP A  37
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
 0.47A 4m2xA-3kjrA:
19.9		 4m2xA-3kjrA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ILE A  29
ASP A  37
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
None
 0.46A 4m2xC-3kjrA:
19.9		 4m2xC-3kjrA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  29
ASP A  37
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
 0.50A 4m2xE-3kjrA:
19.8		 4m2xE-3kjrA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  29
ASP A  37
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-4.5A)
None
None
None
 0.33A 4m2xG-3kjrA:
20.2		 4m2xG-3kjrA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ARG A  39
THR A  69
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
 0.96A 4m6kA-3kjrA:
22.8		 4m6kA-3kjrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.56A 4m6kA-3kjrA:
22.8		 4m6kA-3kjrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 THR A  69
ILE A  73
PRO A  74
LEU A  80
TYR A 129
 NAP  A 512 (-3.6A)
None
None
None
None
 0.75A 4m6kA-3kjrA:
22.8		 4m6kA-3kjrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
 0.67A 4nx6A-3kjrA:
21.3		 4nx6A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
 0.74A 4nx7A-3kjrA:
21.2		 4nx7A-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 7 PHE A 229
HIS A 226
ILE A 168
ARG A 145
 None
 1.18A 4o7gA-3kjrA:
undetectable
4o7gB-3kjrA:
undetectable		 4o7gA-3kjrA:
20.47
4o7gB-3kjrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
 0.67A 4p3qA-3kjrA:
21.3		 4p3qA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
 0.74A 4p3rA-3kjrA:
21.1		 4p3rA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		3 / 3 ASP A  37
ARG A  83
THR A 144
 None
 0.22A 4p3rA-3kjrA:
21.1		 4p3rA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.38A 4p66A-3kjrA:
21.3		 4p66A-3kjrA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ASP A  37
SER A  72
ILE A  73
ARG A  83
TYR A 129
THR A 144
 None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.60A 4p68A-3kjrA:
21.1		 4p68A-3kjrA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 LEU A 417
GLY A 420
LEU A 450
MET A 261
THR A 274
 None
 1.36A 4p6xI-3kjrA:
undetectable		 4p6xI-3kjrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
 0.76A 4pssA-3kjrA:
undetectable		 4pssA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.68A 4pstA-3kjrA:
undetectable		 4pstA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 0.71A 4psyA-3kjrA:
21.1		 4psyA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.71A 4pthA-3kjrA:
20.9		 4pthA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.62A 4ptjA-3kjrA:
21.1		 4ptjA-3kjrA:
16.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
None
 0.51A 4q0dA-3kjrA:
45.2		 4q0dA-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
None
 0.51A 4q0dB-3kjrA:
45.2		 4q0dB-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.33A 4q0dC-3kjrA:
45.2		 4q0dC-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
SER A  72
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.60A 4q0dC-3kjrA:
45.2		 4q0dC-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.34A 4q0dD-3kjrA:
45.2		 4q0dD-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
SER A  72
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.61A 4q0dD-3kjrA:
45.2		 4q0dD-3kjrA:
46.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
None
 0.51A 4q0dE-3kjrA:
45.2		 4q0dE-3kjrA:
46.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 GLY A 296
ILE A 332
GLY A 311
VAL A 304
ILE A 306
 None
None
None
None
GOL  A 516 (-3.9A)
 0.80A 4q5mA-3kjrA:
undetectable		 4q5mA-3kjrA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.69A 4qi9A-3kjrA:
18.5		 4qi9A-3kjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.42A 4qi9A-3kjrA:
18.5		 4qi9A-3kjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
SER A  72
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.61A 4qi9A-3kjrA:
18.5		 4qi9A-3kjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.65A 4qi9B-3kjrA:
18.7		 4qi9B-3kjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.42A 4qi9B-3kjrA:
18.7		 4qi9B-3kjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
SER A  72
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.65A 4qi9B-3kjrA:
18.7		 4qi9B-3kjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.68A 4qi9C-3kjrA:
17.7		 4qi9C-3kjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.44A 4qi9C-3kjrA:
17.7		 4qi9C-3kjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
SER A  72
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.66A 4qi9C-3kjrA:
17.7		 4qi9C-3kjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.65A 4qleA-3kjrA:
20.4		 4qleA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.69A 4qleB-3kjrA:
20.3		 4qleB-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.39A 4qleB-3kjrA:
20.3		 4qleB-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 11 ALA A  16
ASP A  37
SER A  72
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.65A 4qleB-3kjrA:
20.3		 4qleB-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 11 ALA A  16
ASP A  37
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
None
 0.70A 4qlfA-3kjrA:
17.7		 4qlfA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.64A 4qlgA-3kjrA:
20.6		 4qlgA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.41A 4qlgA-3kjrA:
20.6		 4qlgA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.59A 4qlgB-3kjrA:
20.2		 4qlgB-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.45A 4qlgB-3kjrA:
20.2		 4qlgB-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
None
 0.66A 4rgcA-3kjrA:
21.3		 4rgcA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 TYR A 333
TYR A 428
LEU A 431
PHE A 397
 None
 1.38A 4twdF-3kjrA:
undetectable
4twdG-3kjrA:
undetectable		 4twdF-3kjrA:
21.55
4twdG-3kjrA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 ASP A 416
ALA A 508
THR A 251
TYR A 456
 None
 1.45A 4w5qA-3kjrA:
undetectable		 4w5qA-3kjrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 ASP A 458
ALA A 253
THR A 251
THR A 249
 None
 1.17A 4w5qA-3kjrA:
undetectable		 4w5qA-3kjrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 ASP A 458
ALA A 253
THR A 251
THR A 249
 None
 1.22A 4w5rA-3kjrA:
undetectable		 4w5rA-3kjrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 ASP A 458
ALA A 253
THR A 251
THR A 249
 None
 1.13A 4w5tA-3kjrA:
undetectable		 4w5tA-3kjrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.58A 4x5fA-3kjrA:
20.4		 4x5fA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.42A 4x5fA-3kjrA:
20.4		 4x5fA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
None
 0.64A 4x5fB-3kjrA:
20.5		 4x5fB-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
None
None
 0.62A 4x5gA-3kjrA:
20.2		 4x5gA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.64A 4x5gB-3kjrA:
20.4		 4x5gB-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.50A 4x5gB-3kjrA:
20.4		 4x5gB-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.71A 4x5hA-3kjrA:
20.0		 4x5hA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.71A 4x5iA-3kjrA:
19.9		 4x5iA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
THR A  69
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
 0.49A 4x5jA-3kjrA:
19.9		 4x5jA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 ASP A 458
ALA A 253
THR A 251
THR A 249
 None
 1.17A 4z4cA-3kjrA:
undetectable		 4z4cA-3kjrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 ASP A 458
ALA A 253
THR A 251
THR A 249
 None
 1.15A 4z4fA-3kjrA:
undetectable		 4z4fA-3kjrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 5 ASP A 458
ALA A 253
THR A 251
THR A 249
 None
 1.19A 4z4gA-3kjrA:
undetectable		 4z4gA-3kjrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 5 ASP A 416
ALA A 508
THR A 251
TYR A 456
 None
 1.44A 4z4hA-3kjrA:
0.0		 4z4hA-3kjrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 ASP A 416
ALA A 508
THR A 251
TYR A 456
 None
 1.42A 4z4iA-3kjrA:
undetectable		 4z4iA-3kjrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 ASP A 458
ALA A 253
THR A 251
THR A 249
 None
 1.14A 4z4iA-3kjrA:
undetectable		 4z4iA-3kjrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_1
(ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 9 ILE A  34
THR A 174
SER A 178
PRO A  30
LEU A 143
 None
None
None
None
GOL  A 517 ( 4.9A)
 1.47A 5alcH-3kjrA:
0.0		 5alcH-3kjrA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 HIS A 459
ASP A 458
THR A 251
LEU A 419
GLY A 420
 None
 1.48A 5axdC-3kjrA:
undetectable		 5axdC-3kjrA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ALA A  16
THR A  69
ILE A  73
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
 0.59A 5e8qA-3kjrA:
20.2		 5e8qA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		3 / 3 ASP A  37
LEU A  80
ARG A  83
 None
 0.47A 5e8qA-3kjrA:
20.2		 5e8qA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.80A 5e8qB-3kjrA:
20.2		 5e8qB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.75A 5eajA-3kjrA:
20.2		 5eajA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.74A 5eajB-3kjrA:
20.3		 5eajB-3kjrA:
16.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 ILE A 306
TRP A 307
ASN A 310
LEU A 390
ASP A 416
LEU A 419
GLY A 420
TYR A 456
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
 0.51A 5fctA-3kjrA:
45.2		 5fctA-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 TRP A 307
ASN A 310
LEU A 390
ASP A 416
LEU A 419
GLY A 420
TYR A 456
MET A 509
 GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.73A 5fctA-3kjrA:
45.2		 5fctA-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		10 / 12 LYS A 275
VAL A 277
ILE A 306
TRP A 307
LEU A 390
CYH A 393
LEU A 419
TYR A 456
MET A 507
MET A 509
 None
None
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.64A 5fctB-3kjrA:
45.3		 5fctB-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		3 / 3 ASN A 310
ASP A 416
GLY A 420
 GOL  A 516 (-3.7A)
None
None
 0.26A 5fctB-3kjrA:
45.3		 5fctB-3kjrA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 7 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.65A 5h3aB-3kjrA:
12.3		 5h3aB-3kjrA:
32.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.72A 5hi6A-3kjrA:
20.3		 5hi6A-3kjrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.45A 5hi6A-3kjrA:
20.3		 5hi6A-3kjrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
SER A  72
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
 0.62A 5hi6A-3kjrA:
20.3		 5hi6A-3kjrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
ASP A  37
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
None
 0.50A 5hi6B-3kjrA:
20.4		 5hi6B-3kjrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		7 / 12 ALA A  16
ASP A  37
SER A  72
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 ( 4.2A)
None
None
None
None
 0.99A 5hi6B-3kjrA:
20.4		 5hi6B-3kjrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 GLU A 285
ILE A 306
LEU A 390
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
None
None
None
None
None
None
 0.50A 5j7wC-3kjrA:
39.2		 5j7wC-3kjrA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 12 GLU A 285
ILE A 306
TRP A 307
LEU A 390
ASP A 416
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
 0.53A 5j7wD-3kjrA:
38.8		 5j7wD-3kjrA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 9 ILE A 122
VAL A  62
ASP A  10
ILE A 108
 None
 1.02A 5lg3I-3kjrA:
undetectable		 5lg3I-3kjrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 HIS A 459
ASP A 458
THR A 251
LEU A 419
GLY A 420
 None
 1.44A 5m66A-3kjrA:
2.7		 5m66A-3kjrA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		3 / 3 HIS A 448
ASN A 449
ALA A 451
 None
 0.81A 5n4tB-3kjrA:
undetectable		 5n4tB-3kjrA:
19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 7 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.72A 5nooA-3kjrA:
39.9		 5nooA-3kjrA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 7 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.71A 5nooB-3kjrA:
39.4		 5nooB-3kjrA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.71A 5nooC-3kjrA:
39.2		 5nooC-3kjrA:
35.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 8 ALA A  16
ASP A  37
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
 0.19A 5uihA-3kjrA:
19.4		 5uihA-3kjrA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.78A 5ujxA-3kjrA:
20.2		 5ujxA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.72A 5ujxB-3kjrA:
20.2		 5ujxB-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
LEU A  80
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.52A 5ujxB-3kjrA:
20.2		 5ujxB-3kjrA:
16.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ASP A 416
LEU A 419
GLY A 420
TYR A 456
MET A 507
MET A 509
 None
None
None
None
None
GOL  A 516 (-4.0A)
 0.72A 5x5qB-3kjrA:
43.0		 5x5qB-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 GLU A 285
ILE A 306
TRP A 307
LEU A 419
GLY A 420
TYR A 456
 GOL  A 516 (-3.2A)
GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
 0.81A 5x5qB-3kjrA:
43.0		 5x5qB-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ILE A 306
ASP A 416
LEU A 419
GLY A 420
ALA A 511
 GOL  A 516 (-3.9A)
None
None
None
None
 1.16A 5x5qB-3kjrA:
43.0		 5x5qB-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ILE A 306
TRP A 307
ASP A 416
LEU A 419
GLY A 420
TYR A 456
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
 0.83A 5x5qB-3kjrA:
43.0		 5x5qB-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 TRP A 307
ASP A 416
LEU A 419
GLY A 420
TYR A 456
MET A 507
 GOL  A 516 (-3.7A)
None
None
None
None
None
 0.78A 5x5qB-3kjrA:
43.0		 5x5qB-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 7 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.61A 5x5qC-3kjrA:
40.8		 5x5qC-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 8 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.61A 5x5qD-3kjrA:
41.3		 5x5qD-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.60A 5x5qE-3kjrA:
41.0		 5x5qE-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 8 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.61A 5x5qF-3kjrA:
40.9		 5x5qF-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ASP A 416
LEU A 419
GLY A 420
ASN A 424
TYR A 456
MET A 509
 None
None
None
None
None
GOL  A 516 (-4.0A)
 0.33A 5x66A-3kjrA:
42.7
5x66B-3kjrA:
12.6		 5x66A-3kjrA:
37.27
5x66B-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 ILE A 306
ASP A 416
GLY A 420
ASN A 424
TYR A 456
 GOL  A 516 (-3.9A)
None
None
None
None
 0.76A 5x66A-3kjrA:
42.7
5x66B-3kjrA:
12.6		 5x66A-3kjrA:
37.27
5x66B-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 9 ASP A 416
LEU A 419
GLY A 420
ASN A 424
TYR A 456
MET A 509
 None
None
None
None
None
GOL  A 516 (-4.0A)
 0.38A 5x66C-3kjrA:
42.8		 5x66C-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 9 ILE A 306
ASP A 416
LEU A 419
GLY A 420
ASN A 424
TYR A 456
 GOL  A 516 (-3.9A)
None
None
None
None
None
 0.73A 5x66C-3kjrA:
42.8		 5x66C-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ASP A 416
GLY A 420
ASN A 424
TYR A 456
MET A 509
 None
None
None
None
GOL  A 516 (-4.0A)
 0.28A 5x66D-3kjrA:
42.7		 5x66D-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ILE A 306
ASP A 416
GLY A 420
ASN A 424
TYR A 456
 GOL  A 516 (-3.9A)
None
None
None
None
 0.75A 5x66D-3kjrA:
42.7		 5x66D-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 LYS A 275
ASP A 416
LEU A 419
GLY A 420
TYR A 456
MET A 509
 None
None
None
None
None
GOL  A 516 (-4.0A)
 0.27A 5x66F-3kjrA:
42.8		 5x66F-3kjrA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 LYS A 275
ILE A 306
ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
GOL  A 516 (-3.9A)
None
None
None
None
 0.70A 5x66F-3kjrA:
42.8		 5x66F-3kjrA:
37.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
ARG A  83
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.65A 5z6fA-3kjrA:
21.3		 5z6fA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.68A 5z6jA-3kjrA:
21.1		 5z6jA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.75A 5z6kA-3kjrA:
21.0		 5z6kA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 11 ALA A  16
ASP A  37
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
None
None
None
 1.00A 5z6mA-3kjrA:
20.2		 5z6mA-3kjrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 GLY A 330
THR A 294
TYR A 351
TYR A 344
 None
 1.30A 6ag0A-3kjrA:
undetectable		 6ag0A-3kjrA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A  16
ASP A  37
THR A  69
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
 0.19A 6aogA-3kjrA:
45.9		 6aogA-3kjrA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A  16
ASP A  37
THR A  69
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
None
NAP  A 512 (-3.6A)
None
None
 0.20A 6aogB-3kjrA:
46.0		 6aogB-3kjrA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 6 GLN A 230
LEU A 272
ARG A 469
PRO A 471
 None
 1.20A 6brdB-3kjrA:
undetectable		 6brdB-3kjrA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 12 HIS A 459
ASP A 458
THR A 251
LEU A 419
GLY A 420
 None
 1.47A 6f3nB-3kjrA:
undetectable		 6f3nB-3kjrA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		5 / 10 ALA A 426
LEU A 271
LEU A 272
TYR A 231
VAL A 277
 None
 1.41A 6g2pB-3kjrA:
undetectable		 6g2pB-3kjrA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 5 ASN A 247
GLY A 418
HIS A 454
ASP A 452
 None
 1.16A 6gh9A-3kjrA:
undetectable		 6gh9A-3kjrA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		4 / 4 ASP A  58
ILE A  48
PRO A  49
LEU A  53
 None
 1.35A 6mkeB-3kjrA:
undetectable		 6mkeB-3kjrA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ILE A 306
TRP A 307
LEU A 390
LEU A 419
GLY A 420
PHE A 423
ASN A 424
TYR A 456
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
 0.63A 6qxsB-3kjrA:
38.1		 6qxsB-3kjrA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ILE A 306
TRP A 307
ASP A 416
LEU A 419
GLY A 420
ASN A 424
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
 0.50A 6qxsD-3kjrA:
38.1		 6qxsD-3kjrA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ILE A 306
TRP A 307
LEU A 390
ASP A 416
LEU A 419
GLY A 420
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
 0.75A 6qxsD-3kjrA:
38.1		 6qxsD-3kjrA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ILE A 306
TRP A 307
LEU A 390
HIS A 394
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
 0.60A 6qyaB-3kjrA:
37.7		 6qyaB-3kjrA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ILE A 306
TRP A 307
HIS A 394
LEU A 419
GLY A 420
PHE A 423
ASN A 424
TYR A 456
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
 0.46A 6qyaD-3kjrA:
37.7		 6qyaD-3kjrA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 12 ILE A 306
TRP A 307
LEU A 390
HIS A 394
LEU A 419
GLY A 420
PHE A 423
TYR A 456
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
 0.59A 6qyaD-3kjrA:
37.7		 6qyaD-3kjrA:
28.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		11 / 12 ILE A 306
TRP A 307
ASN A 310
LEU A 390
ASP A 416
LEU A 419
GLY A 420
PHE A 423
ASN A 424
TYR A 456
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.54A 6r2eA-3kjrA:
44.8		 6r2eA-3kjrA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 10 ILE A 306
TRP A 307
ASN A 310
LEU A 390
ASP A 416
LEU A 419
GLY A 420
ASN A 424
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.53A 6r2eB-3kjrA:
44.5		 6r2eB-3kjrA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 10 ILE A 306
TRP A 307
ASN A 310
LEU A 390
ASP A 416
LEU A 419
GLY A 420
ASN A 424
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.59A 6r2eC-3kjrA:
44.9		 6r2eC-3kjrA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		9 / 10 ILE A 306
TRP A 307
ASN A 310
LEU A 390
ASP A 416
LEU A 419
GLY A 420
ASN A 424
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.53A 6r2eD-3kjrA:
44.6		 6r2eD-3kjrA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		10 / 12 ILE A 306
TRP A 307
ASN A 310
TYR A 333
LEU A 390
LEU A 419
GLY A 420
PHE A 423
ASN A 424
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.50A 6r2eE-3kjrA:
44.6		 6r2eE-3kjrA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 ILE A 306
TRP A 307
ASN A 310
ASP A 416
LEU A 419
GLY A 420
ASN A 424
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.37A 6r2eF-3kjrA:
44.6		 6r2eF-3kjrA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		8 / 11 ILE A 306
TRP A 307
ASN A 310
LEU A 390
ASP A 416
LEU A 419
GLY A 420
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
GOL  A 516 (-4.0A)
 0.50A 6r2eF-3kjrA:
44.6		 6r2eF-3kjrA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		10 / 11 ILE A 306
TRP A 307
ASN A 310
LEU A 390
ASP A 416
LEU A 419
GLY A 420
PHE A 423
ASN A 424
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.51A 6r2eG-3kjrA:
44.6		 6r2eG-3kjrA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		10 / 12 ILE A 306
TRP A 307
ASN A 310
TYR A 333
LEU A 390
ASP A 416
LEU A 419
GLY A 420
ASN A 424
MET A 509
 GOL  A 516 (-3.9A)
GOL  A 516 (-3.7A)
GOL  A 516 (-3.7A)
None
None
None
None
None
None
GOL  A 516 (-4.0A)
 0.58A 6r2eH-3kjrA:
44.5		 6r2eH-3kjrA:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE
(Babesia
bovis) 		6 / 12 ALA A  16
THR A  69
ILE A  73
LEU A  80
TYR A 129
THR A 144
 NAP  A 512 (-3.7A)
NAP  A 512 (-3.6A)
None
None
None
None
 0.60A 7dfrA-3kjrA:
21.2		 7dfrA-3kjrA:
16.49