SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kjx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 5 GLY A  87
PRO A  99
VAL A  69
ILE A 127
 None
 0.67A 2aoiA-3kjxA:
undetectable		 2aoiA-3kjxA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 4 LEU A 289
PRO A 290
LEU A 261
ARG A 233
 None
 1.41A 2qd2A-3kjxA:
4.4		 2qd2A-3kjxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 7 PHE A 188
ILE A 217
THR A 191
GLY A 279
 None
 0.96A 2v0mB-3kjxA:
undetectable		 2v0mB-3kjxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_H_CSCH1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 THR A 337
LEU A 338
ARG A 300
PHE A 248
ASP A 254
 None
 1.03A 2vavH-3kjxA:
2.8		 2vavH-3kjxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 6 LEU A 240
ILE A 275
ILE A 332
MET A 296
 None
 0.93A 2xkwB-3kjxA:
undetectable		 2xkwB-3kjxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 LEU A  97
VAL A  69
SER A 124
VAL A  91
LEU A  85
 None
 1.25A 2zlcA-3kjxA:
undetectable		 2zlcA-3kjxA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 ARG A 300
LEU A  76
PRO A  74
ILE A 165
VAL A 163
 None
 1.24A 2zznA-3kjxA:
undetectable		 2zznA-3kjxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 LEU A 229
GLY A 232
LEU A 261
GLY A 260
GLY A 259
 None
 1.00A 3axzA-3kjxA:
4.4		 3axzA-3kjxA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 6 ALA A 312
GLY A 125
LEU A  97
VAL A  69
 None
 0.93A 4dubB-3kjxA:
undetectable		 4dubB-3kjxA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		3 / 3 ARG A 200
TYR A 251
ASN A 281
 None
 0.94A 4ffwB-3kjxA:
2.8		 4ffwB-3kjxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 7 ILE A 275
LEU A 277
LYS A 231
GLY A 232
 None
 0.76A 4hajA-3kjxA:
undetectable		 4hajA-3kjxA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 5 PRO A 330
ASP A 297
ILE A 303
VAL A  80
 None
 1.19A 4hytA-3kjxA:
2.2		 4hytA-3kjxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		3 / 3 VAL A  20
SER A  21
THR A  24
 None
 0.47A 4luhA-3kjxA:
undetectable		 4luhA-3kjxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		3 / 3 VAL A  35
SER A  36
THR A  39
 None
 0.43A 4luhA-3kjxA:
undetectable		 4luhA-3kjxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 GLY A 276
PHE A 248
GLY A 187
PHE A 206
ILE A 178
 None
 1.44A 5tuiB-3kjxA:
2.7		 5tuiB-3kjxA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 LEU A 277
LEU A 249
GLY A 273
GLY A 182
ARG A 184
 None
 1.05A 6ce2B-3kjxA:
undetectable		 6ce2B-3kjxA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 10 GLY A 125
VAL A  71
VAL A 149
ALA A 307
LEU A  92
 None
 1.01A 6czmA-3kjxA:
undetectable
6czmC-3kjxA:
undetectable		 6czmA-3kjxA:
24.62
6czmC-3kjxA:
24.62