SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		4 / 8 VAL A  97
TYR A 361
GLY A  74
TYR A 109
 None
 0.96A 1jlfA-3kk7A:
2.2
1jlfB-3kk7A:
2.1		 1jlfA-3kk7A:
20.48
1jlfB-3kk7A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		4 / 7 VAL A  97
TYR A 361
GLY A  74
TYR A 109
 None
 1.01A 1lweA-3kk7A:
undetectable		 1lweA-3kk7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 259
ASP A 254
ASN A 249
 None
 0.69A 2bm9D-3kk7A:
undetectable		 2bm9D-3kk7A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 530
LEU A 425
ILE A 555
ILE A 506
TYR A 214
 None
 1.41A 2efjA-3kk7A:
undetectable		 2efjA-3kk7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A  44
GLU A 493
SER A  47
 None
 0.58A 2xkkA-3kk7A:
undetectable
2xkkC-3kk7A:
undetectable		 2xkkA-3kk7A:
20.43
2xkkC-3kk7A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 232
GLY A 358
ASP A 357
LEU A  73
TYR A  77
 None
 0.97A 2zw9A-3kk7A:
undetectable		 2zw9A-3kk7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 232
GLY A 358
ASP A 357
LEU A  73
TYR A  77
 None
 0.96A 2zw9B-3kk7A:
undetectable		 2zw9B-3kk7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 230
LEU A 360
ILE A 367
GLU A 227
VAL A  96
 None
 1.50A 3tmzA-3kk7A:
undetectable		 3tmzA-3kk7A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 394
LEU A 466
LYS A 467
ASN A 418
 None
 1.21A 4g19A-3kk7A:
undetectable		 4g19A-3kk7A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A 190
VAL A  96
LEU A 205
LEU A  73
LEU A 102
 None
 1.28A 4or0B-3kk7A:
undetectable		 4or0B-3kk7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A 377
PHE A 372
TYR A 556
 None
 0.84A 4u15A-3kk7A:
undetectable		 4u15A-3kk7A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 423
TYR A 393
TYR A 530
LEU A 466
 None
 1.28A 5bmvB-3kk7A:
undetectable		 5bmvB-3kk7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		5 / 9 ALA A 263
ILE A 264
ILE A 291
ALA A 241
LEU A 179
 None
 1.11A 5mvmA-3kk7A:
undetectable
5mvmE-3kk7A:
undetectable		 5mvmA-3kk7A:
9.23
5mvmE-3kk7A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		6 / 10 ILE A 291
ALA A 241
LEU A 179
ALA A 263
ILE A 264
ILE A 301
 None
 1.20A 5mvmD-3kk7A:
undetectable
5mvmE-3kk7A:
undetectable		 5mvmD-3kk7A:
9.23
5mvmE-3kk7A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 316
ALA A 239
ASP A  88
PHE A  89
 None
 1.01A 5mvsA-3kk7A:
undetectable		 5mvsA-3kk7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 337
SER A 343
GLY A 317
GLY A 237
VAL A 183
 None
 1.23A 5o4yD-3kk7A:
undetectable
5o4yE-3kk7A:
undetectable		 5o4yD-3kk7A:
2.13
5o4yE-3kk7A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A 176
SER A 126
LYS A 256
 None
 1.50A 5os7A-3kk7A:
undetectable		 5os7A-3kk7A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 221
VAL A 210
LEU A 205
ILE A 506
PHE A 372
 None
 1.49A 5tixA-3kk7A:
undetectable		 5tixA-3kk7A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 556
THR A 419
ARG A 420
GLN A 421
 None
 1.36A 5tzoB-3kk7A:
undetectable		 5tzoB-3kk7A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 556
THR A 419
ARG A 420
GLN A 421
 None
 1.38A 5tzoC-3kk7A:
undetectable		 5tzoC-3kk7A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 242
ASN A  91
LEU A 315
 None
 0.70A 6exiD-3kk7A:
undetectable		 6exiD-3kk7A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A 176
SER A 126
LYS A 256
 None
 1.50A 6gmdB-3kk7A:
undetectable		 6gmdB-3kk7A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 105
LYS A 199
TYR A 109
 EDO  A 605 ( 3.7A)
EDO  A 605 (-2.9A)
None
 0.97A 6gnaA-3kk7A:
undetectable		 6gnaA-3kk7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 105
LYS A 199
TYR A 109
 EDO  A 605 ( 3.7A)
EDO  A 605 (-2.9A)
None
 0.97A 6gnbA-3kk7A:
undetectable		 6gnbA-3kk7A:
21.32