SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 164
ARG A 195
LEU A 296
VAL A 323
 None
ACT  A   1 (-2.7A)
None
None
 1.24A 1gsfA-3kkeA:
undetectable		 1gsfA-3kkeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 164
ARG A 195
LEU A 296
VAL A 323
 None
ACT  A   1 (-2.7A)
None
None
 1.24A 1gsfB-3kkeA:
1.5		 1gsfB-3kkeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 164
ARG A 195
LEU A 296
VAL A 322
 None
ACT  A   1 (-2.7A)
None
None
 0.79A 1gsfC-3kkeA:
undetectable		 1gsfC-3kkeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 164
ARG A 195
LEU A 296
VAL A 323
 None
ACT  A   1 (-2.7A)
None
None
 1.24A 1gsfD-3kkeA:
undetectable		 1gsfD-3kkeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 10 VAL A 276
ILE A 167
GLY A 166
THR A 202
ILE A 173
 None
 1.11A 1z11C-3kkeA:
undetectable		 1z11C-3kkeA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 263
GLY A 257
ALA A 258
GLY A 277
VAL A 269
 None
 0.99A 2f80A-3kkeA:
undetectable		 2f80A-3kkeA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 263
GLY A 257
ALA A 258
GLY A 277
VAL A 269
 None
 1.02A 2f8gA-3kkeA:
undetectable		 2f8gA-3kkeA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 PRO A 270
LEU A 259
ARG A 268
GLY A 266
 None
 1.23A 2hs2B-3kkeA:
undetectable		 2hs2B-3kkeA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 263
GLY A 257
ALA A 258
GLY A 277
VAL A 269
 None
 0.95A 2ieoA-3kkeA:
undetectable		 2ieoA-3kkeA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 195
GLY A 164
PRO A 297
THR A 327
 ACT  A   1 (-2.7A)
None
None
None
 1.21A 2m2oB-3kkeA:
undetectable		 2m2oB-3kkeA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ALA A 258
ALA A 255
GLY A 185
SER A 226
ALA A 224
 None
 1.35A 2vh3A-3kkeA:
undetectable		 2vh3A-3kkeA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 263
GLY A 257
ALA A 258
GLY A 277
VAL A 269
 None
 0.99A 3d20A-3kkeA:
undetectable		 3d20A-3kkeA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A 320
SER A 156
ARG A 153
 None
 0.77A 3loqA-3kkeA:
3.7		 3loqA-3kkeA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 263
GLY A 257
ALA A 258
GLY A 277
VAL A 269
 None
 1.05A 3ucbA-3kkeA:
undetectable		 3ucbA-3kkeA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 330
ASP A 160
ILE A 278
GLY A 198
VAL A 294
 None
 0.80A 3ucbA-3kkeA:
undetectable		 3ucbA-3kkeA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 160
ILE A 278
GLY A 198
VAL A 276
VAL A 294
 None
 0.90A 3ucbB-3kkeA:
undetectable		 3ucbB-3kkeA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 330
ASP A 160
ILE A 278
GLY A 198
VAL A 294
 None
 0.87A 3ucbB-3kkeA:
undetectable		 3ucbB-3kkeA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 152
ASP A 190
ASP A 161
ASP A 320
VAL A 157
 None
 1.14A 4b17A-3kkeA:
2.3		 4b17A-3kkeA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 320
ARG A 194
ASP A 190
ASN A 147
LEU A 301
 None
None
None
ACT  A   1 (-3.2A)
None
 1.38A 5l7iB-3kkeA:
0.0		 5l7iB-3kkeA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 HIS A 189
GLU A 127
TRP A 220
 None
None
ACT  A   1 (-3.6A)
 1.27A 5odiD-3kkeA:
5.6		 5odiD-3kkeA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 HIS A 189
GLU A 127
TRP A 220
 None
None
ACT  A   1 (-3.6A)
 1.07A 5odqD-3kkeA:
5.6		 5odqD-3kkeA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 HIS A 189
GLU A 127
TRP A 220
 None
None
ACT  A   1 (-3.6A)
 1.20A 5odrD-3kkeA:
5.6		 5odrD-3kkeA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A  74
VAL A 249
VAL A 283
GLY A 257
ALA A 258
 None
 1.10A 5x23A-3kkeA:
undetectable		 5x23A-3kkeA:
20.62