SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kkz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
5 / 10 THR A  73
GLY A 100
LEU A 108
PHE A 110
GLY A 103
None
1.44A 1h4oA-3kkzA:
undetectable
1h4oB-3kkzA:
undetectable
1h4oA-3kkzA:
18.70
1h4oB-3kkzA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
4 / 6 LEU A 108
SER A 104
ASP A 106
GLU A 135
None
SAM  A 301 (-3.1A)
None
None
1.22A 2j2pE-3kkzA:
undetectable
2j2pF-3kkzA:
undetectable
2j2pE-3kkzA:
20.36
2j2pF-3kkzA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQE_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
4 / 5 TYR A 249
SER A 152
CYH A 151
TYR A 247
None
1.44A 2kqeA-3kkzA:
0.0
2kqeA-3kkzA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
5 / 11 THR A  73
ILE A 101
GLY A  74
PRO A 109
ILE A  53
None
1.36A 2y7kA-3kkzA:
undetectable
2y7kA-3kkzA:
24.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
12 / 12 ARG A  25
GLN A  26
GLY A  54
GLY A  56
GLN A  60
LEU A  75
PHE A  77
LEU A  78
SER A 104
GLU A 121
ALA A 123
ASN A 126
SAM  A 301 (-3.7A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
None
None
SAM  A 301 ( 4.1A)
SAM  A 301 (-3.1A)
None
SAM  A 301 ( 3.7A)
SAM  A 301 (-3.0A)
0.00A 3kkzA-3kkzA:
46.9
3kkzA-3kkzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
12 / 12 ARG A  25
GLN A  26
GLY A  27
GLY A  54
GLY A  56
GLN A  60
PHE A  77
LEU A  78
SER A 104
GLU A 121
ALA A 123
ASN A 126
SAM  A 301 (-3.7A)
SAM  A 301 (-4.4A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
None
SAM  A 301 ( 4.1A)
SAM  A 301 (-3.1A)
None
SAM  A 301 ( 3.7A)
SAM  A 301 (-3.0A)
0.28A 3kkzB-3kkzA:
43.7
3kkzB-3kkzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
11 / 12 ARG A  25
GLN A  26
GLY A  54
GLY A  56
GLN A  60
SER A 104
MET A 105
GLU A 121
ALA A 123
TYR A 125
ASN A 126
SAM  A 301 (-3.7A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.5A)
None
SAM  A 301 ( 3.7A)
None
SAM  A 301 (-3.0A)
0.29A 3sxjA-3kkzA:
38.4
3sxjA-3kkzA:
61.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
11 / 12 ARG A  25
GLN A  26
GLY A  54
GLY A  56
GLN A  60
SER A 104
MET A 105
GLU A 121
ALA A 123
TYR A 125
ASN A 126
SAM  A 301 (-3.7A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.5A)
None
SAM  A 301 ( 3.7A)
None
SAM  A 301 (-3.0A)
0.29A 3sxjB-3kkzA:
38.4
3sxjB-3kkzA:
61.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
11 / 12 ARG A  25
GLY A  54
GLY A  56
GLN A  60
ASP A  76
PHE A  77
SER A 104
MET A 105
GLU A 121
ALA A 123
ASN A 126
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.8A)
None
SAM  A 301 (-3.1A)
SAM  A 301 (-4.5A)
None
SAM  A 301 ( 3.7A)
SAM  A 301 (-3.0A)
0.39A 3t7sA-3kkzA:
39.9
3t7sA-3kkzA:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
5 / 12 GLN A  26
GLY A  54
GLY A  56
ASP A  76
ALA A 123
SAM  A 301 (-4.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.8A)
SAM  A 301 ( 3.7A)
1.23A 3t7sA-3kkzA:
39.9
3t7sA-3kkzA:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
12 / 12 ARG A  25
GLN A  26
GLY A  54
GLY A  56
GLN A  60
ASP A  76
PHE A  77
SER A 104
MET A 105
GLU A 121
ALA A 123
ASN A 126
SAM  A 301 (-3.7A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.8A)
None
SAM  A 301 (-3.1A)
SAM  A 301 (-4.5A)
None
SAM  A 301 ( 3.7A)
SAM  A 301 (-3.0A)
0.33A 3t7sB-3kkzA:
39.3
3t7sB-3kkzA:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
10 / 12 ARG A  25
GLY A  54
GLY A  56
GLN A  60
SER A 104
MET A 105
GLU A 121
ALA A 123
TYR A 125
ASN A 126
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.5A)
None
SAM  A 301 ( 3.7A)
None
SAM  A 301 (-3.0A)
0.29A 3t7sC-3kkzA:
40.0
3t7sC-3kkzA:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
12 / 12 ARG A  25
GLN A  26
GLY A  54
GLY A  56
GLN A  60
ASP A  76
PHE A  77
SER A 104
MET A 105
GLU A 121
ALA A 123
ASN A 126
SAM  A 301 (-3.7A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.8A)
None
SAM  A 301 (-3.1A)
SAM  A 301 (-4.5A)
None
SAM  A 301 ( 3.7A)
SAM  A 301 (-3.0A)
0.32A 3t7sD-3kkzA:
37.8
3t7sD-3kkzA:
69.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
5 / 12 LEU A 189
LEU A 260
GLY A 187
LEU A 133
VAL A 180
None
1.34A 4olmA-3kkzA:
undetectable
4olmA-3kkzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
5 / 12 ASP A  52
GLY A  54
THR A  61
ASP A  76
MET A 105
None
SAM  A 301 (-3.7A)
None
SAM  A 301 (-2.8A)
SAM  A 301 (-4.5A)
1.38A 4pghB-3kkzA:
13.1
4pghB-3kkzA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
4 / 7 GLU A 236
TYR A 249
LEU A 196
TYR A 205
None
1.12A 4twdF-3kkzA:
undetectable
4twdJ-3kkzA:
undetectable
4twdF-3kkzA:
21.25
4twdJ-3kkzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
3 / 3 ILE A  53
MET A  62
ASP A  76
None
None
SAM  A 301 (-2.8A)
0.81A 5h2uA-3kkzA:
undetectable
5h2uA-3kkzA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
5 / 12 GLY A  29
ILE A  53
GLY A 122
SER A 149
ALA A 147
None
None
SAM  A 301 (-4.8A)
None
None
1.08A 6c2mB-3kkzA:
undetectable
6c2mB-3kkzA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
4 / 8 ILE A 176
GLN A 179
VAL A 180
TYR A 188
None
1.04A 6cduG-3kkzA:
undetectable
6cduH-3kkzA:
undetectable
6cduG-3kkzA:
22.49
6cduH-3kkzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis)
4 / 7 GLY A 100
ASN A  88
GLU A  24
GLY A  59
None
0.87A 6n7fA-3kkzA:
undetectable
6n7fA-3kkzA:
15.33