SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 5 ASP A 224
GLY A  18
ALA A 134
ILE A 198
 None
 0.91A 2aofA-3kl0A:
undetectable		 2aofA-3kl0A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		3 / 3 PHE A 158
VAL A 137
TRP A 150
 None
 0.91A 2cc8A-3kl0A:
undetectable		 2cc8A-3kl0A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		3 / 3 PHE A 158
VAL A 137
TRP A 150
 None
 0.90A 2ccbA-3kl0A:
undetectable		 2ccbA-3kl0A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		7 / 12 TRP A  85
ASN A 139
GLU A 140
HIS A 202
TYR A 204
GLU A 229
TRP A 268
 None
None
HIS  A 405 (-2.7A)
None
HIS  A 405 ( 3.5A)
HIS  A 406 (-3.2A)
HIS  A 406 ( 3.2A)
 0.46A 2v3dA-3kl0A:
32.8		 2v3dA-3kl0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		6 / 11 TRP A  85
ASN A 139
GLU A 140
TYR A 204
GLU A 229
TRP A 268
 None
None
HIS  A 405 (-2.7A)
HIS  A 405 ( 3.5A)
HIS  A 406 (-3.2A)
HIS  A 406 ( 3.2A)
 0.53A 2v3dB-3kl0A:
32.7		 2v3dB-3kl0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 8 PHE A  19
GLY A  20
GLY A 300
MET A 257
 None
 0.82A 2y6rB-3kl0A:
undetectable		 2y6rB-3kl0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 5 LEU A 203
GLN A 210
THR A 206
LEU A 199
 None
 1.13A 3ce6D-3kl0A:
undetectable		 3ce6D-3kl0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 5 LEU A 203
GLN A 210
THR A 206
LEU A 225
 None
 1.17A 3ce6D-3kl0A:
undetectable		 3ce6D-3kl0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 7 LEU A 362
TYR A 288
VAL A 230
ILE A 253
 None
 1.13A 3ik3A-3kl0A:
undetectable		 3ik3A-3kl0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 7 LEU A 362
TYR A 288
VAL A 230
ILE A 253
 None
 1.11A 3ik3B-3kl0A:
undetectable		 3ik3B-3kl0A:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 4 GLY A 300
TYR A 301
GLY A 321
ASP A 322
 None
 0.15A 3kl3A-3kl0A:
69.3		 3kl3A-3kl0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KL3_B_DHIB404_0
(GLUCURONOXYLANASE
XYNC)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 4 GLU A 140
TYR A 143
TYR A 204
TYR A 231
 HIS  A 405 (-2.7A)
HIS  A 405 (-4.1A)
HIS  A 405 ( 3.5A)
HIS  A 405 (-4.5A)
 0.35A 3kl3B-3kl0A:
68.8		 3kl3B-3kl0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		5 / 9 LEU A 362
TYR A 288
VAL A 230
ILE A 253
LEU A  47
 None
 1.29A 3oxzA-3kl0A:
undetectable		 3oxzA-3kl0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		3 / 3 LYS A 180
SER A 209
GLN A 210
 None
 1.30A 3si7A-3kl0A:
undetectable		 3si7A-3kl0A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 8 PHE A  19
GLY A  20
GLY A 300
MET A 257
 None
 0.76A 3v3nB-3kl0A:
undetectable		 3v3nB-3kl0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 8 PHE A  19
GLY A  20
GLY A 300
MET A 257
 None
 0.76A 3v3nC-3kl0A:
undetectable		 3v3nC-3kl0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		5 / 10 ARG A 298
PHE A  19
GLY A  20
GLY A 300
MET A 257
 None
 1.44A 3v3oD-3kl0A:
undetectable		 3v3oD-3kl0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 6 PHE A 375
ALA A 377
ALA A 329
THR A 385
 None
MLA  A 403 ( 4.5A)
None
None
 0.95A 4dtzA-3kl0A:
undetectable		 4dtzA-3kl0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 8 SER A 357
ALA A 329
SER A 383
THR A 385
 None
 0.64A 4iklA-3kl0A:
undetectable
4iklB-3kl0A:
undetectable		 4iklA-3kl0A:
15.19
4iklB-3kl0A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 4 ASN A 289
VAL A 328
THR A 356
ILE A 355
 None
 0.98A 4retA-3kl0A:
undetectable		 4retA-3kl0A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 4 ASN A 289
VAL A 328
THR A 356
ILE A 355
 None
 0.98A 4retC-3kl0A:
undetectable		 4retC-3kl0A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		3 / 3 ARG A  17
ASP A 224
TRP A 226
 None
 1.17A 4xdqA-3kl0A:
undetectable		 4xdqA-3kl0A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 8 ILE A 253
TYR A 265
PHE A  49
GLY A 287
 None
 0.92A 5esfA-3kl0A:
undetectable		 5esfA-3kl0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_1
(METTL3)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 4 ASP A  57
HIS A 117
ASN A 139
GLN A 138
 None
 1.28A 5il1A-3kl0A:
0.7		 5il1A-3kl0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 7 PHE A 296
VAL A 326
ILE A 253
THR A 386
 None
 1.05A 5vkqA-3kl0A:
undetectable
5vkqD-3kl0A:
undetectable		 5vkqA-3kl0A:
12.64
5vkqD-3kl0A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		3 / 3 ASN A 162
VAL A  56
HIS A 117
 None
 0.81A 6a5yD-3kl0A:
undetectable		 6a5yD-3kl0A:
12.05