SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		5 / 9 GLY A 240
ASP A 213
ILE A  99
PHE A 269
ILE A 243
 None
 1.18A 1cetA-3kl4A:
undetectable		 1cetA-3kl4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		5 / 10 LEU A 116
VAL A 127
TYR A 120
GLY A 128
LEU A 101
 None
 1.46A 1fkoA-3kl4A:
1.7		 1fkoA-3kl4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 GLU A   3
GLY A   1
ILE A  35
ASP A  29
 None
 0.77A 1jg4A-3kl4A:
undetectable		 1jg4A-3kl4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 LEU A 101
LEU A 129
GLY A 128
ILE A 181
 None
 0.90A 1mt1G-3kl4A:
undetectable
1mt1J-3kl4A:
undetectable		 1mt1G-3kl4A:
9.07
1mt1J-3kl4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		4 / 7 ILE A 181
LEU A 101
LEU A 129
GLY A 128
 None
 0.90A 1mt1H-3kl4A:
undetectable
1mt1K-3kl4A:
undetectable		 1mt1H-3kl4A:
14.55
1mt1K-3kl4A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 LEU A 101
LEU A 129
GLY A 128
ILE A 181
 None
 0.88A 1n13A-3kl4A:
undetectable
1n13F-3kl4A:
undetectable		 1n13A-3kl4A:
9.07
1n13F-3kl4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 THR A 263
SER A 231
HIS A 234
ASP A 213
ILE A 215
 None
 1.04A 2b25B-3kl4A:
undetectable		 2b25B-3kl4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 PHE A  70
LEU A  78
LEU A  47
ILE A  51
ILE A  27
 None
 1.02A 2bxqA-3kl4A:
4.0		 2bxqA-3kl4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 LEU A  30
LEU A  34
ILE A  71
SER A  37
VAL A 288
 None
 1.16A 2po5A-3kl4A:
2.8		 2po5A-3kl4A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		4 / 7 ILE A 183
ILE A 276
LEU A 146
ILE A 150
 None
 0.89A 2q83A-3kl4A:
undetectable		 2q83A-3kl4A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		4 / 7 ILE A 181
LEU A 101
LEU A 129
GLY A 128
 None
 0.90A 2qqcD-3kl4A:
undetectable
2qqcE-3kl4A:
undetectable		 2qqcD-3kl4A:
14.49
2qqcE-3kl4A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 ILE A 181
LEU A 101
LEU A 129
GLY A 128
 None
 0.90A 2qqcH-3kl4A:
undetectable
2qqcK-3kl4A:
undetectable		 2qqcH-3kl4A:
14.49
2qqcK-3kl4A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 ILE A 181
LEU A 101
LEU A 129
GLY A 128
 None
 0.90A 2qqdB-3kl4A:
undetectable
2qqdC-3kl4A:
undetectable		 2qqdB-3kl4A:
14.72
2qqdC-3kl4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		4 / 5 LYS A  80
LEU A  81
GLU A  77
LEU A  47
 None
 1.05A 4k4yA-3kl4A:
undetectable		 4k4yA-3kl4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		4 / 4 LYS A  80
LEU A  81
GLU A  77
LEU A  47
 None
 1.06A 4k4yE-3kl4A:
undetectable		 4k4yE-3kl4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		4 / 5 LYS A  80
LEU A  81
GLU A  77
LEU A  47
 None
 1.09A 4k4yI-3kl4A:
undetectable		 4k4yI-3kl4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		5 / 10 ILE A 291
PHE A 282
GLY A 254
GLY A 253
MET A 247
 None
 1.40A 5lbtA-3kl4A:
2.4
5lbtB-3kl4A:
undetectable		 5lbtA-3kl4A:
19.86
5lbtB-3kl4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		5 / 10 VAL A 288
ILE A 291
LEU A   2
ALA A 284
PHE A  82
 None
 1.20A 5mxbA-3kl4A:
undetectable		 5mxbA-3kl4A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 GLY A 293
LEU A 292
VAL A 288
THR A  14
GLY A  15
 None
 1.17A 6gngA-3kl4A:
2.4		 6gngA-3kl4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN
(Sulfolobus
solfataricus) 		3 / 3 THR A 328
GLU A 419
ASN A 425
 None
 0.74A 6nj9K-3kl4A:
2.7		 6nj9K-3kl4A:
21.73