SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kl8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		5 / 11 ILE A 123
LEU A 136
LEU A  97
LEU A 206
LEU A 205
 None
 1.02A 1dtlA-3kl8A:
undetectable		 1dtlA-3kl8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		5 / 9 VAL A  27
LYS A  42
LEU A  75
LEU A  87
LEU A  91
 None
 0.56A 1xkkA-3kl8A:
21.4		 1xkkA-3kl8A:
23.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		6 / 12 VAL A  73
VAL A  92
ASN A 140
LEU A 142
ALA A 155
ASP A 156
 None
 0.67A 2eufB-3kl8A:
27.0		 2eufB-3kl8A:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		4 / 6 VAL A  27
LYS A  42
LEU A 142
ASP A 156
 None
 0.87A 3cs9D-3kl8A:
21.7		 3cs9D-3kl8A:
26.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		4 / 7 LYS A  42
LEU A  87
LEU A  91
ILE A  72
 None
 0.85A 3gp0A-3kl8A:
23.0		 3gp0A-3kl8A:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		4 / 6 GLN A 118
LEU A 120
GLU A 121
LEU A 265
 None
 0.74A 3h5gA-3kl8A:
undetectable
3h5gC-3kl8A:
undetectable		 3h5gA-3kl8A:
11.98
3h5gC-3kl8A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		3 / 3 GLU A 235
ASP A 237
ASP A 230
 None
 0.75A 3jb2A-3kl8A:
undetectable		 3jb2A-3kl8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		4 / 7 LEU A 142
VAL A  73
LEU A  67
ASP A 156
 None
 0.95A 3rgfA-3kl8A:
4.1		 3rgfA-3kl8A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		4 / 5 HIS A 127
LEU A 251
LEU A 202
ASP A 248
 None
 1.30A 4aqlA-3kl8A:
undetectable		 4aqlA-3kl8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		4 / 6 ILE A 195
ILE A 119
SER A 122
LEU A 265
 None
 0.92A 4m51A-3kl8A:
undetectable		 4m51A-3kl8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		5 / 10 ALA A  40
LYS A  42
LEU A  91
VAL A  92
LEU A 142
 None
 0.70A 4rz7A-3kl8A:
11.4		 4rz7A-3kl8A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		4 / 5 LEU A 143
GLU A  96
LEU A 205
HIS A 114
 None
 1.36A 4xi3B-3kl8A:
undetectable		 4xi3B-3kl8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		4 / 6 PRO A 211
GLU A 242
ALA A 264
LEU A 120
 None
 1.06A 5igiA-3kl8A:
8.1		 5igiA-3kl8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
(Caenorhabditis
elegans) 		4 / 8 LEU A  97
ALA A 197
GLN A 118
HIS A 133
 None
 0.90A 5nu7A-3kl8A:
undetectable		 5nu7A-3kl8A:
18.66