SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kl9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		3 / 3 VAL A 312
VAL A 235
TRP A 180
 None
 0.91A 1av2A-3kl9A:
undetectable
1av2B-3kl9A:
undetectable		 1av2A-3kl9A:
3.49
1av2B-3kl9A:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		3 / 3 TRP A 180
ALA A 240
VAL A 312
 None
 0.95A 1av2C-3kl9A:
undetectable
1av2D-3kl9A:
undetectable		 1av2C-3kl9A:
3.49
1av2D-3kl9A:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 THR A 254
LEU A 233
ALA A 234
ALA A 295
LEU A 265
 None
 0.97A 1jinA-3kl9A:
0.8		 1jinA-3kl9A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 10 ASP A  68
SER A  65
ALA A  64
THR A 309
ASP A 181
 None
None
None
None
ZN  A 356 ( 2.4A)
 1.42A 1m4dA-3kl9A:
0.0		 1m4dA-3kl9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 9 GLY A  90
PRO A 162
GLU A  69
GLY A  71
ASP A 181
 None
None
None
None
ZN  A 356 ( 2.4A)
 0.99A 1mxdA-3kl9A:
undetectable		 1mxdA-3kl9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A  90
PRO A 162
GLU A  69
GLY A  71
ASP A 181
 None
None
None
None
ZN  A 356 ( 2.4A)
 0.96A 1mxgA-3kl9A:
undetectable		 1mxgA-3kl9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 9 ALA A  64
GLY A 219
ALA A 220
LEU A  62
PHE A 227
 None
 0.90A 1nr6A-3kl9A:
undetectable		 1nr6A-3kl9A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 274
GLU A 278
ILE A 256
TYR A 286
 None
 0.97A 1qvtA-3kl9A:
undetectable		 1qvtA-3kl9A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		3 / 3 VAL A 312
VAL A 235
TRP A 180
 None
 0.87A 1w5uA-3kl9A:
undetectable
1w5uB-3kl9A:
undetectable		 1w5uA-3kl9A:
3.49
1w5uB-3kl9A:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		3 / 3 VAL A 235
TRP A 180
VAL A 312
 None
 0.92A 2izqC-3kl9A:
undetectable
2izqD-3kl9A:
undetectable		 2izqC-3kl9A:
3.49
2izqD-3kl9A:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A 205
VAL A 231
ILE A 351
VAL A  63
VAL A  61
 None
 0.93A 2nnpB-3kl9A:
undetectable		 2nnpB-3kl9A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A   4
SER A 177
VAL A 186
GLY A 185
 None
 1.07A 2qd5A-3kl9A:
3.0		 2qd5A-3kl9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A   4
SER A 177
VAL A 186
GLY A 185
 None
 1.06A 2qd5B-3kl9A:
2.7		 2qd5B-3kl9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		6 / 12 LEU A 205
ASN A 203
GLY A 202
VAL A 231
ILE A 351
VAL A  63
 None
 1.21A 3bvbA-3kl9A:
undetectable		 3bvbA-3kl9A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLU A 213
THR A 293
ASP A 181
GLY A  90
HIS A 318
 ZN  A 355 (-3.6A)
None
ZN  A 356 ( 2.4A)
None
ZN  A 356 (-3.5A)
 1.34A 3ce6D-3kl9A:
undetectable		 3ce6D-3kl9A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 7 TYR A 354
LEU A 266
LYS A 352
SER A 307
 None
 0.93A 3lslA-3kl9A:
undetectable
3lslD-3kl9A:
undetectable		 3lslA-3kl9A:
21.82
3lslD-3kl9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 7 SER A 307
TYR A 354
LEU A 266
LYS A 352
 None
 0.92A 3lslA-3kl9A:
undetectable
3lslD-3kl9A:
undetectable		 3lslA-3kl9A:
21.82
3lslD-3kl9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 10 LEU A 205
GLY A 202
VAL A 231
VAL A  63
VAL A  61
 None
 1.10A 3nu9B-3kl9A:
undetectable		 3nu9B-3kl9A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ACTA908_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 4 MET A  67
SER A  65
LEU A  28
VAL A 186
 None
 1.25A 3vlnA-3kl9A:
0.6		 3vlnA-3kl9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ACTA908_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 4 MET A  67
SER A 209
LEU A  28
VAL A 186
 None
 1.19A 3vlnA-3kl9A:
0.6		 3vlnA-3kl9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 7 PHE A 101
PHE A 139
GLY A 116
ILE A 134
PHE A  72
 None
 1.47A 4ejjA-3kl9A:
undetectable		 4ejjA-3kl9A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASP A 344
ASP A 349
ARG A 345
GLU A 230
 None
 1.15A 4eysA-3kl9A:
undetectable		 4eysA-3kl9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 8 GLU A  69
HIS A  66
GLY A 185
SER A  65
 None
ZN  A 355 (-3.7A)
None
None
 1.01A 4f93B-3kl9A:
undetectable		 4f93B-3kl9A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 5 TYR A 286
THR A 347
LEU A 343
THR A 309
 None
 1.35A 4mbsB-3kl9A:
undetectable		 4mbsB-3kl9A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 5 LEU A 207
SER A 209
LEU A  62
LEU A 192
 None
 1.26A 4n09B-3kl9A:
2.2		 4n09B-3kl9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 5 LEU A 207
SER A 209
LEU A  62
LEU A 192
 None
 1.28A 4n09D-3kl9A:
2.4		 4n09D-3kl9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A  42
SER A  65
ASN A 210
GLY A  45
GLY A 208
 None
 1.28A 4pevB-3kl9A:
3.2		 4pevB-3kl9A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		8 / 11 HIS A  66
ASP A 181
GLU A 213
GLU A 214
ARG A 257
GLY A 289
ILE A 317
HIS A 318
 ZN  A 355 (-3.7A)
ZN  A 356 ( 2.4A)
ZN  A 355 (-3.6A)
ZN  A 356 (-2.0A)
None
None
None
ZN  A 356 (-3.5A)
 0.79A 4pqaA-3kl9A:
22.3		 4pqaA-3kl9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		8 / 11 HIS A  66
ASP A 181
GLU A 213
GLU A 214
GLY A 289
GLY A 291
ILE A 317
HIS A 318
 ZN  A 355 (-3.7A)
ZN  A 356 ( 2.4A)
ZN  A 355 (-3.6A)
ZN  A 356 (-2.0A)
None
None
None
ZN  A 356 (-3.5A)
 0.87A 4pqaA-3kl9A:
22.3		 4pqaA-3kl9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 4 VAL A 340
ALA A 338
PHE A 272
THR A 276
 None
 1.41A 4z4fA-3kl9A:
2.4		 4z4fA-3kl9A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 4 VAL A 340
ALA A 338
PHE A 272
THR A 276
 None
 1.43A 4z4hA-3kl9A:
2.5		 4z4hA-3kl9A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 6 GLU A 191
PHE A 329
GLU A  10
VAL A  11
 None
 1.24A 5h4dA-3kl9A:
undetectable		 5h4dA-3kl9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A 296
GLY A 292
SER A  65
ARG A 218
ALA A 220
 None
 1.03A 5o96G-3kl9A:
undetectable		 5o96G-3kl9A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A 330
ASP A 252
ILE A 250
 None
 0.64A 6dh0B-3kl9A:
undetectable		 6dh0B-3kl9A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 6 ILE A 282
GLY A 253
TYR A 284
GLU A 331
 None
 1.08A 6gqiA-3kl9A:
2.1		 6gqiA-3kl9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 THR A 308
VAL A 235
THR A 254
PHE A 335
THR A 276
 None
 1.26A 6hcoA-3kl9A:
undetectable
6hcoB-3kl9A:
undetectable		 6hcoA-3kl9A:
21.19
6hcoB-3kl9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 7 HIS A  20
THR A 159
GLU A  21
ASP A  68
 None
 1.36A 6mn4E-3kl9A:
undetectable		 6mn4E-3kl9A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASP A  42
GLU A  21
ASP A  68
GLU A 213
 None
None
None
ZN  A 355 (-3.6A)
 1.18A 6mn5A-3kl9A:
undetectable		 6mn5A-3kl9A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASP A  42
GLU A  21
ASP A  68
GLU A 213
 None
None
None
ZN  A 355 (-3.6A)
 1.33A 6mn5C-3kl9A:
undetectable		 6mn5C-3kl9A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3kl9 GLUTAMYL
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASP A  42
GLU A  21
ASP A  68
GLU A 213
 None
None
None
ZN  A 355 (-3.6A)
 1.18A 6mn5D-3kl9A:
undetectable		 6mn5D-3kl9A:
12.86