SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3klb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3klb PUTATIVE
FLAVOPROTEIN
(Bacteroides
fragilis) 		4 / 6 LEU A  81
ALA A  30
LEU A  24
ALA A  21
 None
EDO  A 166 ( 4.6A)
None
None
 0.87A 2vcvB-3klbA:
undetectable		 2vcvB-3klbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3klb PUTATIVE
FLAVOPROTEIN
(Bacteroides
fragilis) 		5 / 9 LEU A  81
ALA A  30
LEU A  24
ALA A  21
PHE A 113
 None
EDO  A 166 ( 4.6A)
None
None
None
 0.99A 2vcvI-3klbA:
undetectable		 2vcvI-3klbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3klb PUTATIVE
FLAVOPROTEIN
(Bacteroides
fragilis) 		3 / 3 LEU A 151
TRP A 155
GLY A 140
 EDO  A 170 (-4.9A)
None
None
 0.77A 3l35A-3klbA:
undetectable
3l35H-3klbA:
undetectable		 3l35A-3klbA:
11.11
3l35H-3klbA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3klb PUTATIVE
FLAVOPROTEIN
(Bacteroides
fragilis) 		3 / 3 LEU A 151
TRP A 155
GLY A 140
 EDO  A 170 (-4.9A)
None
None
 0.73A 3l35B-3klbA:
undetectable
3l35K-3klbA:
undetectable		 3l35B-3klbA:
11.11
3l35K-3klbA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3klb PUTATIVE
FLAVOPROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A 128
ASN A 127
ALA A  92
ALA A 114
ILE A  96
 None
 1.13A 3ut5D-3klbA:
4.4		 3ut5D-3klbA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3klb PUTATIVE
FLAVOPROTEIN
(Bacteroides
fragilis) 		5 / 12 VAL A   8
ALA A   9
PHE A 156
GLY A  84
THR A  28
 None
 1.13A 4mm4A-3klbA:
undetectable		 4mm4A-3klbA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3klb PUTATIVE
FLAVOPROTEIN
(Bacteroides
fragilis) 		5 / 12 VAL A   8
ALA A   9
PHE A 156
GLY A  84
THR A  28
 None
 1.20A 4mm4B-3klbA:
undetectable		 4mm4B-3klbA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3klb PUTATIVE
FLAVOPROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A 128
ASN A 127
ALA A  92
ALA A 114
ILE A  96
 None
 1.09A 4x1iD-3klbA:
4.2		 4x1iD-3klbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3klb PUTATIVE
FLAVOPROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A 128
ASN A 127
ALA A  92
ALA A 114
ILE A  96
 None
 1.19A 5eypB-3klbA:
4.3		 5eypB-3klbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 3klb PUTATIVE
FLAVOPROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A 128
ASN A 127
ALA A  92
ALA A 114
ILE A  96
 None
 1.15A 5nm5B-3klbA:
4.7		 5nm5B-3klbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3klb PUTATIVE
FLAVOPROTEIN
(Bacteroides
fragilis) 		4 / 7 TYR A 103
PHE A 105
GLY A  84
TYR A  10
 None
GOL  A 165 (-4.9A)
None
None
 0.92A 5uxdA-3klbA:
undetectable		 5uxdA-3klbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 3klb PUTATIVE
FLAVOPROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A 128
ASN A 127
ALA A  92
ALA A 114
ILE A  96
 None
 1.17A 5xiwD-3klbA:
4.3		 5xiwD-3klbA:
19.23