SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3klq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 3klq PUTATIVE PILUS
ANCHORING PROTEIN
(Streptococcus
pyogenes) 		4 / 8 TYR A  90
TYR A  61
VAL A  86
TYR A  87
 None
 1.03A 2fl5E-3klqA:
2.5
2fl5F-3klqA:
3.5		 2fl5E-3klqA:
22.01
2fl5F-3klqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3klq PUTATIVE PILUS
ANCHORING PROTEIN
(Streptococcus
pyogenes) 		5 / 12 PHE A  24
LEU A  15
GLY A  46
VAL A  11
SER A  10
 None
 1.20A 3dh0A-3klqA:
undetectable		 3dh0A-3klqA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3klq PUTATIVE PILUS
ANCHORING PROTEIN
(Streptococcus
pyogenes) 		3 / 3 ARG A 104
ASP A  83
ASP A 107
 None
 0.88A 3jb2A-3klqA:
undetectable		 3jb2A-3klqA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3klq PUTATIVE PILUS
ANCHORING PROTEIN
(Streptococcus
pyogenes) 		5 / 12 PHE A 115
VAL A  11
ILE A   9
TYR A  66
VAL A  84
 None
 1.05A 4a97B-3klqA:
undetectable
4a97C-3klqA:
undetectable		 4a97B-3klqA:
18.12
4a97C-3klqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3klq PUTATIVE PILUS
ANCHORING PROTEIN
(Streptococcus
pyogenes) 		5 / 12 GLU A  16
GLY A  46
ALA A  48
THR A  41
ILE A  40
 None
 1.06A 4hytA-3klqA:
undetectable		 4hytA-3klqA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3klq PUTATIVE PILUS
ANCHORING PROTEIN
(Streptococcus
pyogenes) 		5 / 12 GLU A  16
GLY A  46
ALA A  48
THR A  41
ILE A  40
 None
 1.06A 4hytC-3klqA:
undetectable		 4hytC-3klqA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 3klq PUTATIVE PILUS
ANCHORING PROTEIN
(Streptococcus
pyogenes) 		3 / 3 ARG A 119
THR A  22
ASP A  20
 None
 0.86A 5g5gA-3klqA:
undetectable
5g5gB-3klqA:
undetectable		 5g5gA-3klqA:
19.27
5g5gB-3klqA:
19.23