SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 3kly PUTATIVE FORMATE
TRANSPORTER 1
(Vibrio
cholerae) 		4 / 8 GLY A 123
ILE A 126
VAL A  49
ILE A  46
 None
 0.68A 1d4yB-3klyA:
undetectable		 1d4yB-3klyA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3kly PUTATIVE FORMATE
TRANSPORTER 1
(Vibrio
cholerae) 		4 / 8 ALA A  73
LEU A  76
GLY A  77
GLY A  45
 None
 0.80A 1rukH-3klyA:
undetectable
1rukL-3klyA:
undetectable		 1rukH-3klyA:
19.66
1rukL-3klyA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3kly PUTATIVE FORMATE
TRANSPORTER 1
(Vibrio
cholerae) 		5 / 11 ILE A 238
ALA A 226
PHE A 225
LEU A 132
MET A 218
 None
 1.16A 1uduA-3klyA:
undetectable		 1uduA-3klyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3kly PUTATIVE FORMATE
TRANSPORTER 1
(Vibrio
cholerae) 		5 / 9 ILE A 262
GLY A 260
GLY A 167
SER A  92
LEU A  94
 None
 1.08A 2qmmA-3klyA:
undetectable		 2qmmA-3klyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3kly PUTATIVE FORMATE
TRANSPORTER 1
(Vibrio
cholerae) 		4 / 8 ILE A 210
LYS A  32
ILE A  38
GLY A  85
 None
BOG  A 282 ( 3.9A)
None
BOG  A 282 ( 4.3A)
 0.94A 4hdlA-3klyA:
undetectable		 4hdlA-3klyA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3kly PUTATIVE FORMATE
TRANSPORTER 1
(Vibrio
cholerae) 		5 / 12 GLY A  45
PHE A  48
LEU A 121
ASN A 120
LEU A 254
 None
 1.03A 4n49A-3klyA:
undetectable		 4n49A-3klyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3kly PUTATIVE FORMATE
TRANSPORTER 1
(Vibrio
cholerae) 		4 / 6 LYS A  99
ALA A  98
VAL A 269
TYR A 273
 None
 1.08A 5i8fA-3klyA:
undetectable		 5i8fA-3klyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3kly PUTATIVE FORMATE
TRANSPORTER 1
(Vibrio
cholerae) 		4 / 5 SER A 203
VAL A 202
GLY A  71
ALA A 199
 None
 1.07A 5k50A-3klyA:
undetectable		 5k50A-3klyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 3kly PUTATIVE FORMATE
TRANSPORTER 1
(Vibrio
cholerae) 		4 / 5 PHE A  74
PHE A  50
LEU A  76
LEU A  68
 None
 0.93A 5veuH-3klyA:
1.8		 5veuH-3klyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3kly PUTATIVE FORMATE
TRANSPORTER 1
(Vibrio
cholerae) 		5 / 12 MET A 213
ALA A 211
LEU A 127
ILE A  42
VAL A  81
 None
None
None
BOG  A 282 ( 4.1A)
None
 1.43A 5vlmE-3klyA:
undetectable		 5vlmE-3klyA:
20.70