SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3km5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 3km5 LYSINE SPECIFIC
CYSTEINE PROTEASE
(Porphyromonas
gingivalis) 		4 / 7 ALA A1200
ASP A1326
GLY A1202
GLY A1203
 CA  A2012 ( 4.3A)
CA  A2012 (-2.3A)
CA  A2012 (-4.1A)
CA  A2012 ( 4.6A)
 0.77A 2c49B-3km5A:
undetectable		 2c49B-3km5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 3km5 LYSINE SPECIFIC
CYSTEINE PROTEASE
(Porphyromonas
gingivalis) 		4 / 5 ILE A1323
GLY A1246
CYH A1317
HIS A1248
 None
 1.16A 3r0lD-3km5A:
undetectable		 3r0lD-3km5A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3km5 LYSINE SPECIFIC
CYSTEINE PROTEASE
(Porphyromonas
gingivalis) 		5 / 12 ALA A1260
ASP A1179
ALA A1180
ASP A1220
TYR A1222
 None
CA  A2011 (-3.2A)
None
None
None
 1.10A 5kvaA-3km5A:
undetectable		 5kvaA-3km5A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3km5 LYSINE SPECIFIC
CYSTEINE PROTEASE
(Porphyromonas
gingivalis) 		5 / 12 ALA A1260
ASP A1179
ALA A1180
ASP A1220
TYR A1222
 None
CA  A2011 (-3.2A)
None
None
None
 1.16A 5kvaB-3km5A:
undetectable		 5kvaB-3km5A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3km5 LYSINE SPECIFIC
CYSTEINE PROTEASE
(Porphyromonas
gingivalis) 		4 / 7 GLY A1246
PHE A1244
SER A1211
ASN A1272
 None
 1.12A 5n5dB-3km5A:
undetectable		 5n5dB-3km5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3km5 LYSINE SPECIFIC
CYSTEINE PROTEASE
(Porphyromonas
gingivalis) 		4 / 6 PHE A1281
LEU A1283
ARG A1280
GLY A1214
 None
 0.99A 5o4yA-3km5A:
undetectable		 5o4yA-3km5A:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 3km5 LYSINE SPECIFIC
CYSTEINE PROTEASE
(Porphyromonas
gingivalis) 		4 / 7 GLY A1282
TRP A1212
ASP A1247
TYR A1322
 None
 1.29A 6ag0A-3km5A:
undetectable		 6ag0A-3km5A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 3km5 LYSINE SPECIFIC
CYSTEINE PROTEASE
(Porphyromonas
gingivalis) 		4 / 7 GLY A1282
TRP A1212
ASP A1247
TYR A1322
 None
 1.26A 6ag0C-3km5A:
undetectable		 6ag0C-3km5A:
16.02