SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kmh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		3 / 3 GLU A 110
HIS A 171
HIS A 105
 MN  A1001 (-2.6A)
MN  A1001 (-3.3A)
MN  A1001 (-3.2A)
 0.60A 1oe2A-3kmhA:
undetectable		 1oe2A-3kmhA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 5 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.01A 1os2A-3kmhA:
undetectable		 1os2A-3kmhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 4 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.01A 1os2D-3kmhA:
undetectable		 1os2D-3kmhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 4 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.09A 1uttA-3kmhA:
undetectable		 1uttA-3kmhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 4 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.04A 1utzA-3kmhA:
undetectable		 1utzA-3kmhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 4 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.07A 1utzB-3kmhA:
undetectable		 1utzB-3kmhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		5 / 11 LEU A  70
HIS A 171
HIS A 103
HIS A 105
GLU A 110
 None
MN  A1001 (-3.3A)
MN  A1001 (-3.6A)
MN  A1001 (-3.2A)
MN  A1001 (-2.6A)
 0.91A 2dttD-3kmhA:
undetectable
2dttE-3kmhA:
undetectable		 2dttD-3kmhA:
19.92
2dttE-3kmhA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 4 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.03A 2hu6A-3kmhA:
undetectable		 2hu6A-3kmhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 6 PRO A 101
MET A 102
HIS A 198
ASP A 196
 None
 1.46A 2lh8A-3kmhA:
undetectable		 2lh8A-3kmhA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 4 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.05A 2ow9B-3kmhA:
undetectable		 2ow9B-3kmhA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 4 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.04A 2ozrC-3kmhA:
undetectable		 2ozrC-3kmhA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 4 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.05A 2ozrD-3kmhA:
undetectable		 2ozrD-3kmhA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 5 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.04A 3likA-3kmhA:
undetectable		 3likA-3kmhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 4 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.05A 3lilA-3kmhA:
undetectable		 3lilA-3kmhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 5 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.01A 3ljgA-3kmhA:
undetectable		 3ljgA-3kmhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 5 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.03A 3lkaA-3kmhA:
undetectable		 3lkaA-3kmhA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		5 / 12 LEU A  10
LEU A 219
ASN A 221
ALA A  57
ILE A 209
 None
 1.21A 3ut5D-3kmhA:
undetectable		 3ut5D-3kmhA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 8 TRP A  53
PHE A  27
VAL A  46
TYR A 223
 None
 1.15A 4f5zA-3kmhA:
undetectable		 4f5zA-3kmhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		3 / 3 ASP A  48
LEU A  51
VAL A 218
 None
 0.62A 4jecB-3kmhA:
undetectable		 4jecB-3kmhA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		3 / 3 ASP A 194
ASN A 197
SER A  77
 None
 0.74A 4obwA-3kmhA:
undetectable		 4obwA-3kmhA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 7 GLU A 110
PHE A 104
TYR A 170
HIS A 171
 MN  A1001 (-2.6A)
GOL  A 228 (-3.9A)
None
MN  A1001 (-3.3A)
 1.41A 4uciB-3kmhA:
undetectable		 4uciB-3kmhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 8 ILE A  91
LEU A 120
LEU A 157
ILE A 113
 None
 0.78A 4xtaB-3kmhA:
undetectable		 4xtaB-3kmhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 4 LEU A 124
ILE A 112
HIS A 171
VAL A 122
 None
None
MN  A1001 (-3.3A)
None
 0.92A 4xyzA-3kmhA:
undetectable		 4xyzA-3kmhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		5 / 12 GLY A 116
GLY A 185
GLY A 180
HIS A  93
LEU A  68
 None
 1.06A 5gwxA-3kmhA:
undetectable		 5gwxA-3kmhA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 4 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.05A 5n5jA-3kmhA:
undetectable		 5n5jA-3kmhA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		4 / 5 HIS A 171
GLU A 110
HIS A 105
HIS A 103
 MN  A1001 (-3.3A)
MN  A1001 (-2.6A)
MN  A1001 (-3.2A)
MN  A1001 (-3.6A)
 1.02A 5n5kA-3kmhA:
undetectable		 5n5kA-3kmhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		3 / 3 HIS A 103
HIS A 171
HIS A 105
 MN  A1001 (-3.6A)
MN  A1001 (-3.3A)
MN  A1001 (-3.2A)
 0.43A 5zrdA-3kmhA:
undetectable		 5zrdA-3kmhA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3kmh D-LYXOSE ISOMERASE
(Escherichia
coli) 		5 / 12 VAL A 184
LEU A  73
PHE A  17
LEU A  24
VAL A  22
 None
None
None
ACT  A 229 (-4.8A)
None
 1.13A 6a93B-3kmhA:
undetectable		 6a93B-3kmhA:
20.98