SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kmi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3kmi PUTATIVE MEMBRANE
PROTEIN COG4129
(Clostridioides
difficile) 		4 / 4 HIS A 253
ASP A 184
SER A 182
ASP A 170
 None
 1.06A 1n2xA-3kmiA:
undetectable		 1n2xA-3kmiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3kmi PUTATIVE MEMBRANE
PROTEIN COG4129
(Clostridioides
difficile) 		5 / 12 LEU A 185
LEU A 188
ASN A 189
LEU A 191
MET A 218
 None
 1.04A 3d90A-3kmiA:
undetectable		 3d90A-3kmiA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 3kmi PUTATIVE MEMBRANE
PROTEIN COG4129
(Clostridioides
difficile) 		5 / 9 ILE A 255
LYS A 254
LEU A 268
GLU A 271
LEU A 272
 None
 1.27A 3f78A-3kmiA:
undetectable		 3f78A-3kmiA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 3kmi PUTATIVE MEMBRANE
PROTEIN COG4129
(Clostridioides
difficile) 		4 / 5 ASP A 167
GLU A 160
THR A 187
SER A 236
 None
 1.42A 3p2kC-3kmiA:
undetectable		 3p2kC-3kmiA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3kmi PUTATIVE MEMBRANE
PROTEIN COG4129
(Clostridioides
difficile) 		5 / 10 ALA A 245
ILE A 172
ILE A 168
LEU A 231
ILE A 252
 None
 1.31A 4dtaA-3kmiA:
undetectable		 4dtaA-3kmiA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3kmi PUTATIVE MEMBRANE
PROTEIN COG4129
(Clostridioides
difficile) 		3 / 3 ILE A 196
ILE A 203
MET A 218
 None
 0.69A 5i9yA-3kmiA:
undetectable		 5i9yA-3kmiA:
21.29