SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kmu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		5 / 12 ALA A 302
LEU A 446
LEU A 382
LEU A 281
ALA A 333
 None
 1.02A 1bzfA-3kmuA:
undetectable		 1bzfA-3kmuA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 8 ALA A 298
LEU A 385
HIS A 420
LEU A 424
 None
 0.84A 1ereE-3kmuA:
undetectable		 1ereE-3kmuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 8 ALA A 298
LEU A 385
HIS A 420
LEU A 424
 None
 0.84A 1ereF-3kmuA:
undetectable		 1ereF-3kmuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		7 / 12 LEU A 199
LYS A 220
LEU A 267
THR A 269
MET A 272
GLY A 275
ASP A 339
 None
 0.88A 1m17A-3kmuA:
24.6		 1m17A-3kmuA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 3kmu ALPHA-PARVIN
(Homo
sapiens) 		5 / 12 THR B 357
VAL B 360
LEU B 361
LEU B 303
LEU B 364
 None
 1.14A 1mx1C-3kmuB:
undetectable		 1mx1C-3kmuB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 4 HIS A 247
VAL A 250
THR A 310
LEU A 314
 None
 1.35A 1oq5A-3kmuA:
undetectable		 1oq5A-3kmuA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 8 ARG A 410
ASN A 321
SER A 377
ARG A 436
 None
 1.05A 1u1jA-3kmuA:
undetectable		 1u1jA-3kmuA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 8 ASN A 321
SER A 377
ARG A 436
VAL A 356
 None
 1.31A 1u1jA-3kmuA:
undetectable		 1u1jA-3kmuA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 7 ASN A 279
ASN A 200
ARG A 323
VAL A 218
 None
 1.26A 1wu8A-3kmuA:
undetectable
1wu8C-3kmuA:
undetectable		 1wu8A-3kmuA:
22.62
1wu8C-3kmuA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 7 PHE A 378
LEU A 299
ALA A 302
PHE A 439
 None
 0.83A 2vcvL-3kmuA:
undetectable		 2vcvL-3kmuA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_1
(PHOSPHOLIPASE A2)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 4 SER A 259
PRO A 261
PHE A 190
PRO A 263
 None
 1.18A 3bjwA-3kmuA:
0.0		 3bjwA-3kmuA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_2
(PHOSPHOLIPASE A2)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 4 SER A 259
PRO A 261
PHE A 190
PRO A 263
 None
 1.17A 3bjwG-3kmuA:
0.0		 3bjwG-3kmuA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 5 SER A 259
PRO A 261
PHE A 190
PRO A 263
 None
 1.18A 3bjwC-3kmuA:
undetectable		 3bjwC-3kmuA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_1
(PHOSPHOLIPASE A2)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 4 SER A 259
PRO A 261
PHE A 190
PRO A 263
 None
 1.18A 3bjwD-3kmuA:
0.0		 3bjwD-3kmuA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		3 / 3 ASN A 279
HIS A 282
VAL A 390
 None
 0.82A 3elzB-3kmuA:
undetectable		 3elzB-3kmuA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 6 VAL A 250
MET A 272
ILE A 315
ILE A 335
 None
 0.79A 3gcsA-3kmuA:
18.8		 3gcsA-3kmuA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		5 / 7 LYS A 220
VAL A 250
LEU A 267
MET A 272
ILE A 335
 None
 1.06A 3gp0A-3kmuA:
19.6		 3gp0A-3kmuA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		5 / 12 TYR A 274
ILE A 327
PHE A 287
ALA A 294
PHE A 297
 None
 0.99A 3gwwA-3kmuA:
0.4		 3gwwA-3kmuA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		5 / 11 LEU A 193
ILE A 188
PHE A 235
SER A 232
LEU A 207
 None
 0.95A 4dm8A-3kmuA:
undetectable		 4dm8A-3kmuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 6 PHE A 235
ALA A 256
ALA A 262
PRO A 263
 None
 1.02A 4dtzA-3kmuA:
undetectable		 4dtzA-3kmuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 3kmu ALPHA-PARVIN
(Homo
sapiens) 		4 / 8 ASN B 326
PHE B 329
ALA B 330
LEU B 298
 None
 0.72A 4ejgB-3kmuB:
undetectable		 4ejgB-3kmuB:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		5 / 12 ALA A 302
MET A 375
LEU A 382
ILE A 427
ILE A 445
 None
 1.12A 4nx6A-3kmuA:
undetectable		 4nx6A-3kmuA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3kmu ALPHA-PARVIN
(Homo
sapiens) 		4 / 6 LEU B 361
LEU B 303
PHE B 290
LEU B 276
 None
 0.86A 5gs4A-3kmuB:
undetectable		 5gs4A-3kmuB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 3kmu ALPHA-PARVIN
(Homo
sapiens) 		4 / 5 LEU B 361
LEU B 303
PHE B 290
LEU B 276
 None
 0.92A 5gtrA-3kmuB:
undetectable		 5gtrA-3kmuB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 8 GLU A 238
VAL A 340
GLN A 345
LEU A 222
 None
 0.97A 5syjB-3kmuA:
undetectable		 5syjB-3kmuA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 7 TRP A 271
ASP A 328
MET A 331
TYR A 274
 None
 1.44A 6ag0A-3kmuA:
undetectable		 6ag0A-3kmuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 3kmu INTEGRIN-LINKED
KINASE
(Homo
sapiens) 		4 / 7 TRP A 271
ASP A 328
MET A 331
TYR A 274
 None
 1.45A 6ag0C-3kmuA:
undetectable		 6ag0C-3kmuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kmu INTEGRIN-LINKED
KINASE
ALPHA-PARVIN
(Homo
sapiens;
Homo
sapiens) 		4 / 5 LEU B 364
TYR B 368
ILE A 400
GLY B 337
 None
 0.98A 6hd6A-3kmuB:
undetectable		 6hd6A-3kmuB:
23.20