SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		5 / 12 LEU A 676
LEU A 667
LEU A 668
LEU A 687
MET A 525
 None
 1.29A 1a28B-3kn5A:
undetectable		 1a28B-3kn5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		3 / 3 ASP A 426
LEU A 425
HIS A 485
 None
 0.79A 1qknA-3kn5A:
undetectable		 1qknA-3kn5A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		4 / 5 ILE A 664
TRP A 653
LEU A 668
PRO A 621
 None
 1.17A 1s8fA-3kn5A:
undetectable
1s8fB-3kn5A:
undetectable		 1s8fA-3kn5A:
20.49
1s8fB-3kn5A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		5 / 12 LEU A 676
LEU A 667
LEU A 668
LEU A 687
MET A 525
 None
 1.30A 1sqnA-3kn5A:
undetectable		 1sqnA-3kn5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		4 / 7 ALA A 717
ILE A 637
ILE A 641
PHE A 722
 None
 0.90A 1upfB-3kn5A:
undetectable		 1upfB-3kn5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		7 / 12 LEU A 432
GLY A 433
ALA A 453
ASP A 544
LYS A 546
ASN A 549
ASP A 565
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.6A)
ANP  A 400 ( 3.8A)
None
ANP  A 400 ( 4.2A)
ANP  A 400 ( 4.4A)
None
 0.60A 2fumA-3kn5A:
22.4		 2fumA-3kn5A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		5 / 12 LEU A 676
LEU A 667
LEU A 668
LEU A 687
MET A 525
 None
 1.28A 2w8yB-3kn5A:
undetectable		 2w8yB-3kn5A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		4 / 7 LEU A 698
GLU A 518
ALA A 531
ILE A 563
 None
 0.76A 2xkwA-3kn5A:
undetectable		 2xkwA-3kn5A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		5 / 12 LEU A 676
LEU A 667
LEU A 668
LEU A 687
MET A 525
 None
 1.33A 3d90A-3kn5A:
undetectable		 3d90A-3kn5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		5 / 12 LEU A 676
LEU A 667
LEU A 668
LEU A 687
MET A 525
 None
 1.30A 3d90B-3kn5A:
undetectable		 3d90B-3kn5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		8 / 12 LEU A 432
GLY A 433
GLY A 435
ALA A 453
LYS A 455
VAL A 482
MET A 498
LEU A 501
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.6A)
ANP  A 400 ( 4.3A)
ANP  A 400 ( 3.8A)
None
None
None
ANP  A 400 (-4.0A)
 0.61A 3fupB-3kn5A:
21.2		 3fupB-3kn5A:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		4 / 7 LYS A 455
LEU A 496
LEU A 500
ILE A 481
 None
None
ANP  A 400 (-4.6A)
None
 0.97A 3gp0A-3kn5A:
18.1		 3gp0A-3kn5A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		4 / 7 LYS A 455
LEU A 496
LEU A 500
ILE A 563
 None
None
ANP  A 400 (-4.6A)
None
 0.91A 3gp0A-3kn5A:
18.1		 3gp0A-3kn5A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		5 / 12 ALA A 453
LYS A 455
GLU A 468
LEU A 472
LEU A 500
 ANP  A 400 ( 3.8A)
None
None
None
ANP  A 400 (-4.6A)
 0.74A 3hecA-3kn5A:
18.2		 3hecA-3kn5A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		4 / 8 ALA A 453
GLU A 468
LEU A 496
LEU A 500
 ANP  A 400 ( 3.8A)
None
None
ANP  A 400 (-4.6A)
 0.41A 3lfaA-3kn5A:
17.8		 3lfaA-3kn5A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 504
LEU A 501
ILE A 510
ILE A 524
PRO A 547
 None
ANP  A 400 (-4.0A)
None
None
None
 1.04A 3mb5A-3kn5A:
undetectable		 3mb5A-3kn5A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		4 / 7 PHE A 648
PHE A 646
GLY A 666
THR A 669
 None
 0.98A 4ejjB-3kn5A:
undetectable		 4ejjB-3kn5A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		4 / 5 PHE A 648
PHE A 646
GLY A 666
THR A 669
 None
 0.96A 4ejjC-3kn5A:
undetectable		 4ejjC-3kn5A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		7 / 12 ALA A 453
ASP A 544
LYS A 546
ASN A 549
LEU A 551
ILE A 564
ASP A 565
 ANP  A 400 ( 3.8A)
None
ANP  A 400 ( 4.2A)
ANP  A 400 ( 4.4A)
ANP  A 400 (-4.7A)
ANP  A 400 (-3.9A)
None
 0.66A 4i41A-3kn5A:
22.3		 4i41A-3kn5A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		6 / 11 ALA A 453
LYS A 455
GLU A 548
LEU A 551
ILE A 564
ASP A 565
 ANP  A 400 ( 3.8A)
None
ANP  A 400 (-3.2A)
ANP  A 400 (-4.7A)
ANP  A 400 (-3.9A)
None
 0.77A 4iaaA-3kn5A:
21.9		 4iaaA-3kn5A:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		5 / 7 GLY A 433
ALA A 453
ASN A 549
LEU A 551
ASP A 565
 ANP  A 400 (-3.6A)
ANP  A 400 ( 3.8A)
ANP  A 400 ( 4.4A)
ANP  A 400 (-4.7A)
None
 0.77A 4ogrE-3kn5A:
21.1		 4ogrE-3kn5A:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		5 / 12 TRP A 686
LEU A 608
THR A 700
ILE A 510
PHE A 516
 None
 1.40A 4p6xG-3kn5A:
undetectable		 4p6xG-3kn5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		6 / 11 ALA A 453
GLU A 468
MET A 498
LEU A 501
LEU A 551
ASP A 565
 ANP  A 400 ( 3.8A)
None
None
ANP  A 400 (-4.0A)
ANP  A 400 (-4.7A)
None
 0.74A 4qmsA-3kn5A:
22.4		 4qmsA-3kn5A:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		6 / 11 ALA A 453
LYS A 455
GLU A 468
MET A 498
LEU A 501
ASP A 565
 ANP  A 400 ( 3.8A)
None
None
None
ANP  A 400 (-4.0A)
None
 0.81A 4qmsA-3kn5A:
22.4		 4qmsA-3kn5A:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		4 / 8 LEU A 432
ALA A 453
MET A 498
ASN A 502
 ANP  A 400 (-4.1A)
ANP  A 400 ( 3.8A)
None
None
 0.79A 4wboB-3kn5A:
20.5		 4wboB-3kn5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		6 / 12 LEU A 432
ALA A 453
LYS A 455
GLU A 468
LEU A 496
LEU A 500
 ANP  A 400 (-4.1A)
ANP  A 400 ( 3.8A)
None
None
None
ANP  A 400 (-4.6A)
 0.49A 4wkqA-3kn5A:
20.0		 4wkqA-3kn5A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		5 / 12 VAL A 610
ILE A 564
ILE A 481
ASN A 480
HIS A 542
 None
ANP  A 400 (-3.9A)
None
None
None
 1.24A 4xueA-3kn5A:
undetectable		 4xueA-3kn5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		6 / 12 LEU A 432
ALA A 453
LYS A 455
GLU A 468
VAL A 482
LEU A 496
 ANP  A 400 (-4.1A)
ANP  A 400 ( 3.8A)
None
None
None
None
 0.60A 5vcvA-3kn5A:
21.0		 5vcvA-3kn5A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		4 / 4 VAL A 482
LEU A 500
ASN A 549
ASP A 565
 None
ANP  A 400 (-4.6A)
ANP  A 400 ( 4.4A)
None
 1.00A 5vcyA-3kn5A:
21.2		 5vcyA-3kn5A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		7 / 12 LEU A 432
ALA A 453
LYS A 455
GLU A 468
LEU A 496
LEU A 500
ASP A 565
 ANP  A 400 (-4.1A)
ANP  A 400 ( 3.8A)
None
None
None
ANP  A 400 (-4.6A)
None
 0.73A 5y7zB-3kn5A:
14.1		 5y7zB-3kn5A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		7 / 12 LEU A 432
ALA A 453
LYS A 455
GLU A 468
LEU A 500
LEU A 551
ASP A 565
 ANP  A 400 (-4.1A)
ANP  A 400 ( 3.8A)
None
None
ANP  A 400 (-4.6A)
ANP  A 400 (-4.7A)
None
 0.70A 5y7zB-3kn5A:
14.1		 5y7zB-3kn5A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		7 / 12 LEU A 432
ALA A 453
LYS A 455
GLU A 468
LEU A 500
LEU A 551
ASP A 565
 ANP  A 400 (-4.1A)
ANP  A 400 ( 3.8A)
None
None
ANP  A 400 (-4.6A)
ANP  A 400 (-4.7A)
None
 0.62A 5y80A-3kn5A:
22.1		 5y80A-3kn5A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens) 		4 / 8 LEU A 432
LYS A 455
ILE A 564
ASP A 565
 ANP  A 400 (-4.1A)
None
ANP  A 400 (-3.9A)
None
 0.73A 5y9mA-3kn5A:
20.4		 5y9mA-3kn5A:
11.15