SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3knt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3knt N-GLYCOSYLASE/DNA
LYASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 160
TYR A 159
LEU A 179
LEU A 151
ILE A 150
 None
 0.94A 1fmlB-3kntA:
undetectable		 1fmlB-3kntA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 3knt N-GLYCOSYLASE/DNA
LYASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASN A 137
HIS A 133
GLN A  59
PHE A  66
THR A  47
 None
 1.27A 3bl1A-3kntA:
undetectable		 3bl1A-3kntA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3knt N-GLYCOSYLASE/DNA
LYASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A  93
LEU A  78
LYS A  60
GLY A  54
 None
 0.86A 4hajA-3kntA:
undetectable		 4hajA-3kntA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3knt N-GLYCOSYLASE/DNA
LYASE
(Methanocaldococc
us
jannaschii) 		4 / 6 GLY A 183
GLU A 184
ASP A 142
ASP A 181
 None
 0.99A 4uckB-3kntA:
undetectable		 4uckB-3kntA:
20.39