SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3knu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Anaplasma
phagocytophilum) 		9 / 12 SER A  87
PRO A  88
GLY A 112
SER A 131
ILE A 132
VAL A 136
LEU A 137
GLY A 139
GLY A 140
 None
 0.40A 1uakA-3knuA:
23.8		 1uakA-3knuA:
40.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Anaplasma
phagocytophilum) 		3 / 3 LEU A  62
ARG A 113
ILE A 117
 None
 0.60A 2xn5B-3knuA:
undetectable		 2xn5B-3knuA:
15.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Anaplasma
phagocytophilum) 		9 / 12 SER A  87
PRO A  88
GLY A 112
GLY A 116
SER A 131
ILE A 132
LEU A 137
GLY A 139
GLY A 140
 None
 0.43A 3axzA-3knuA:
24.8		 3axzA-3knuA:
40.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Anaplasma
phagocytophilum) 		5 / 12 GLY A  23
ILE A 159
ILE A 148
VAL A 155
VAL A 158
 None
 0.93A 3ucbA-3knuA:
undetectable		 3ucbA-3knuA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Anaplasma
phagocytophilum) 		3 / 3 ARG A 113
PHE A   9
PRO A  10
 None
 0.82A 3zoaB-3knuA:
undetectable		 3zoaB-3knuA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Anaplasma
phagocytophilum) 		4 / 8 PHE A  36
LEU A  77
ILE A   2
THR A  81
 None
 0.75A 4em2A-3knuA:
undetectable		 4em2A-3knuA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Anaplasma
phagocytophilum) 		10 / 12 SER A  87
PRO A  88
GLY A 112
GLU A 115
GLY A 116
SER A 131
ILE A 132
LEU A 137
GLY A 139
GLY A 140
 None
 0.40A 4yvgA-3knuA:
21.8		 4yvgA-3knuA:
40.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Anaplasma
phagocytophilum) 		9 / 12 PRO A  88
GLY A 112
GLY A 116
SER A 131
ILE A 132
VAL A 136
LEU A 137
GLY A 139
GLY A 140
 None
 0.36A 5wyqA-3knuA:
21.5		 5wyqA-3knuA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Anaplasma
phagocytophilum) 		8 / 12 PRO A  88
GLY A 112
SER A 131
ILE A 132
TYR A 135
LEU A 137
GLY A 139
GLY A 140
 None
 0.30A 5wyqB-3knuA:
24.0		 5wyqB-3knuA:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Anaplasma
phagocytophilum) 		10 / 12 PRO A  88
GLY A 112
GLU A 115
GLY A 116
SER A 131
ILE A 132
VAL A 136
LEU A 137
GLY A 139
GLY A 140
 None
 0.63A 5zhmB-3knuA:
24.3		 5zhmB-3knuA:
41.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Anaplasma
phagocytophilum) 		4 / 5 VAL A  49
PRO A  10
MET A  12
VAL A   5
 None
 1.35A 6ekzA-3knuA:
undetectable		 6ekzA-3knuA:
20.44