SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3knw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3knw PUTATIVE
TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)
(Acinetobacter
sp.
ADP1) 		5 / 11 VAL A  32
GLY A  33
LEU A  34
TYR A  49
PHE A  29
 None
 1.37A 1iolA-3knwA:
2.3		 1iolA-3knwA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3knw PUTATIVE
TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)
(Acinetobacter
sp.
ADP1) 		4 / 7 PHE A  58
LEU A  62
LEU A  63
GLU A  36
 None
 0.97A 2jn3A-3knwA:
undetectable		 2jn3A-3knwA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3knw PUTATIVE
TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)
(Acinetobacter
sp.
ADP1) 		5 / 12 ALA A  84
LYS A  87
LEU A  88
ALA A 163
ILE A 166
 None
 1.17A 3ut5B-3knwA:
undetectable		 3ut5B-3knwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3knw PUTATIVE
TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)
(Acinetobacter
sp.
ADP1) 		5 / 12 ALA A  84
LYS A  87
LEU A  88
ALA A 163
ILE A 166
 None
 1.19A 3ut5D-3knwA:
undetectable		 3ut5D-3knwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3knw PUTATIVE
TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)
(Acinetobacter
sp.
ADP1) 		3 / 3 ARG A  13
LEU A  17
PHE A  21
 None
 0.39A 6nknP-3knwA:
undetectable		 6nknP-3knwA:
20.15