SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3knz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A  25
ALA A  22
LEU A 153
LEU A  81
VAL A  31
 None
 1.25A 2bxeA-3knzA:
undetectable		 2bxeA-3knzA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		4 / 5 GLN A  54
THR A  51
ARG A  50
ALA A  49
 None
 1.47A 2qhfA-3knzA:
undetectable		 2qhfA-3knzA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		4 / 8 LEU A  19
LEU A 152
ALA A 154
MET A 176
 None
 1.03A 2wekA-3knzA:
3.1		 2wekA-3knzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		5 / 12 LEU A 152
LEU A  19
MET A 111
PHE A  52
MET A  53
 None
 1.47A 2yloA-3knzA:
undetectable		 2yloA-3knzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		3 / 3 LEU A  12
LEU A 173
ARG A 175
 None
 0.64A 3hcnB-3knzA:
4.4		 3hcnB-3knzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		3 / 3 LEU A 173
LEU A  12
ARG A  16
 None
 0.65A 3hcnB-3knzA:
4.4		 3hcnB-3knzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		5 / 12 VAL A 219
GLY A 222
ALA A 223
LEU A 227
LEU A 230
 None
 0.65A 3hs6A-3knzA:
0.6		 3hs6A-3knzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		5 / 11 THR A  27
GLN A  24
ALA A 158
GLY A 159
ALA A 156
 None
 1.21A 3mg0H-3knzA:
undetectable
3mg0I-3knzA:
undetectable		 3mg0H-3knzA:
20.40
3mg0I-3knzA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		5 / 9 ALA A  49
LEU A  36
LEU A 153
ASN A 149
ILE A  34
 None
 1.44A 3wdmA-3knzA:
8.2		 3wdmA-3knzA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		5 / 9 ALA A 154
ILE A  34
VAL A  83
ALA A  22
ALA A  23
 None
 1.06A 4lbgB-3knzA:
2.9		 4lbgB-3knzA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		4 / 6 LEU A 215
PRO A 261
GLU A 309
TYR A 310
 None
 1.28A 4z4gA-3knzA:
4.2		 4z4gA-3knzA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		4 / 8 HIS A 144
GLN A 315
LEU A   8
LEU A 183
 None
 1.04A 5hs6A-3knzA:
4.9		 5hs6A-3knzA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		4 / 8 ILE A 320
MET A 226
LEU A 295
ILE A 284
 None
 0.91A 5ieoA-3knzA:
undetectable		 5ieoA-3knzA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3knz PUTATIVE SUGAR
BINDING PROTEIN
(Salmonella
enterica) 		5 / 12 THR A  27
GLN A  24
ALA A 158
GLY A 159
ALA A 156
 None
 1.18A 5l5zH-3knzA:
undetectable
5l5zI-3knzA:
undetectable		 5l5zH-3knzA:
20.39
5l5zI-3knzA:
19.95