SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kol'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		3 / 3 THR A  56
PRO A  52
THR A  54
 None
 0.87A 1a7yB-3kolA:
undetectable		 1a7yB-3kolA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		3 / 3 THR A  54
THR A  56
PRO A  52
 None
 0.86A 1a7yB-3kolA:
undetectable		 1a7yB-3kolA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		4 / 4 THR A  54
LEU A  55
VAL A  64
LEU A  77
 None
 0.99A 1mz9D-3kolA:
undetectable		 1mz9D-3kolA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		4 / 7 PHE A 138
GLY A  42
ILE A 116
VAL A 115
 None
 0.55A 1p2yA-3kolA:
undetectable		 1p2yA-3kolA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		3 / 3 THR A  56
PRO A  52
THR A  54
 None
 0.86A 1unmF-3kolA:
undetectable		 1unmF-3kolA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		3 / 3 THR A  54
THR A  56
PRO A  52
 None
 0.84A 1unmF-3kolA:
undetectable		 1unmF-3kolA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		3 / 3 THR A  54
THR A  56
PRO A  52
 None
 0.79A 209dC-3kolA:
undetectable		 209dC-3kolA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		4 / 6 LEU A  41
TYR A  37
ILE A 121
ILE A 146
 None
 0.99A 2q8hA-3kolA:
undetectable		 2q8hA-3kolA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		4 / 8 ALA A  65
ASP A  76
GLY A  38
PRO A 141
 None
 0.78A 3nu9A-3kolA:
undetectable		 3nu9A-3kolA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		4 / 5 PHE A 138
GLY A  42
ILE A 116
VAL A 115
 None
 0.74A 3wrkA-3kolA:
undetectable		 3wrkA-3kolA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		3 / 3 PHE A 109
ASP A 151
ARG A 149
 None
 0.84A 4eahF-3kolA:
undetectable		 4eahF-3kolA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		3 / 3 PHE A 109
ASP A 151
ARG A 149
 None
 0.84A 4eahG-3kolA:
undetectable		 4eahG-3kolA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		4 / 5 GLY A 133
ARG A 149
GLY A 135
GLU A 147
 None
None
None
CO  A 302 (-2.6A)
 1.07A 4z2eB-3kolA:
undetectable
4z2eC-3kolA:
undetectable		 4z2eB-3kolA:
14.99
4z2eC-3kolA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Nostoc
punctiforme) 		4 / 5 PHE A 138
LEU A  43
GLY A  42
ILE A 116
 None
 0.97A 5ik1A-3kolA:
undetectable		 5ik1A-3kolA:
18.90