SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 6 LEU A  47
ILE A  13
ARG A  14
TYR A 295
 None
 1.12A 1db1A-3komA:
undetectable		 1db1A-3komA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		5 / 12 ILE A 341
ILE A 345
MET A 501
ALA A 503
GLU A 338
 None
 1.42A 1ki7B-3komA:
undetectable		 1ki7B-3komA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 5 GLY A 311
GLN A 310
TRP A 309
VAL A 146
 None
 1.36A 1p6kB-3komA:
undetectable		 1p6kB-3komA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 5 GLY A 311
GLN A 310
TRP A 309
VAL A 146
 None
 1.35A 1zzuA-3komA:
undetectable		 1zzuA-3komA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		3 / 3 THR A  40
PRO A   6
TYR A 295
 None
 0.93A 2dxrA-3komA:
0.7		 2dxrA-3komA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 6 MET A  35
PRO A  32
ILE A 249
ASN A  66
 None
 1.12A 2wekB-3komA:
2.1		 2wekB-3komA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 4 TYR A  82
LEU A  84
LEU A  77
HIS A  49
 None
 1.16A 2x7hB-3komA:
2.0		 2x7hB-3komA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 5 ALA A 229
GLY A 220
CYH A 245
LYS A 246
 None
 1.48A 2ylgA-3komA:
undetectable		 2ylgA-3komA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 8 GLY A 250
VAL A 262
LEU A 267
PRO A  29
 None
 0.93A 3bgdB-3komA:
undetectable		 3bgdB-3komA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		5 / 12 VAL A 214
CYH A 244
CYH A 245
MET A  35
HIS A 221
 None
 1.31A 3g8iA-3komA:
undetectable		 3g8iA-3komA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 5 ALA A 229
GLY A 220
CYH A 245
LYS A 246
 None
 1.50A 3zwiA-3komA:
undetectable		 3zwiA-3komA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3kom TRANSKETOLASE
(Francisella
tularensis) 		3 / 3 ASN A  11
TRP A 281
ASP A  37
 None
 1.12A 4a7tA-3komA:
undetectable
4a7tF-3komA:
undetectable		 4a7tA-3komA:
15.46
4a7tF-3komA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		5 / 10 ILE A 537
ILE A 345
LEU A 349
ILE A 498
ASP A 496
 None
 1.28A 4dtaA-3komA:
undetectable		 4dtaA-3komA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		5 / 12 GLY A 432
GLY A 433
LEU A 519
SER A 461
VAL A 364
 None
 0.97A 4htfA-3komA:
undetectable		 4htfA-3komA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		5 / 12 GLY A 432
GLY A 433
LEU A 519
SER A 461
VAL A 364
 None
 0.98A 4htfB-3komA:
undetectable		 4htfB-3komA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 6 ILE A 446
VAL A 459
SER A 449
ASP A 381
 None
 1.10A 4iaqA-3komA:
undetectable		 4iaqA-3komA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 8 VAL A 181
TYR A 152
HIS A 234
ILE A 215
 None
 0.82A 4jq1B-3komA:
undetectable		 4jq1B-3komA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		3 / 3 LEU A  72
ILE A  13
ARG A  14
 None
 0.55A 4mk4B-3komA:
3.4		 4mk4B-3komA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		5 / 11 TYR A 408
PRO A 430
PHE A 376
SER A 379
GLY A 432
 None
 1.25A 4mmaA-3komA:
undetectable		 4mmaA-3komA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		5 / 12 TYR A 408
PRO A 430
PHE A 376
SER A 379
GLY A 432
 None
 1.17A 4mmdB-3komA:
undetectable		 4mmdB-3komA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_2
(ANDROGEN RECEPTOR)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 4 ASN A  91
MET A  71
LEU A  84
HIS A  78
 None
 1.31A 4oktA-3komA:
0.0		 4oktA-3komA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		5 / 12 GLY A 626
VAL A 663
MET A 622
ILE A 601
VAL A 555
 None
 1.34A 4okwA-3komA:
undetectable		 4okwA-3komA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		5 / 12 GLU A 167
GLY A 414
ALA A 445
ALA A 123
ASN A 124
 None
 1.18A 4pclB-3komA:
undetectable		 4pclB-3komA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		5 / 12 ASN A 187
VAL A 248
LEU A 267
ALA A 257
GLY A 264
 None
 1.33A 4qckA-3komA:
undetectable		 4qckA-3komA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		3 / 3 LYS A 505
ARG A 327
VAL A 335
 None
 0.87A 4x3uA-3komA:
undetectable
4x3uB-3komA:
undetectable		 4x3uA-3komA:
7.68
4x3uB-3komA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 6 ILE A   5
HIS A 234
ILE A 243
VAL A 218
 None
 0.94A 4zj8A-3komA:
undetectable		 4zj8A-3komA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 6 ARG A   7
ASP A 219
GLY A 220
ASP A  37
 None
 1.30A 5hp1A-3komA:
2.1		 5hp1A-3komA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 5 ALA A 229
GLY A 220
CYH A 245
LYS A 246
 None
 1.47A 5jliA-3komA:
undetectable		 5jliA-3komA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 5 ALA A 229
GLY A 220
CYH A 245
LYS A 246
 None
 1.45A 5jt4A-3komA:
undetectable		 5jt4A-3komA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 7 ASP A 185
GLY A  69
GLY A  30
HIS A 263
 None
 0.81A 5n9xA-3komA:
2.1		 5n9xA-3komA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		4 / 7 ASP A 185
ASP A 157
GLY A 158
ASN A  66
 None
None
OCS  A 159 ( 2.4A)
None
 1.05A 5x7pA-3komA:
undetectable		 5x7pA-3komA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kom TRANSKETOLASE
(Francisella
tularensis) 		5 / 12 GLN A  94
SER A  97
LEU A  84
ILE A  86
MET A  71
 None
 1.11A 6md4A-3komA:
undetectable		 6md4A-3komA:
8.50