SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kos'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 12 PHE A 242
PRO A 254
ILE A 183
ALA A 228
MET A 224
 None
 1.08A 1fm4A-3kosA:
undetectable		 1fm4A-3kosA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 9 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.33A 1gtfA-3kosA:
undetectable
1gtfB-3kosA:
undetectable		 1gtfA-3kosA:
15.42
1gtfB-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 9 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.31A 1gtnG-3kosA:
undetectable
1gtnH-3kosA:
undetectable		 1gtnG-3kosA:
15.42
1gtnH-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		4 / 5 ILE A 123
LEU A 125
ASP A 142
ALA A 277
 None
None
GOL  A   2 (-2.6A)
None
 0.97A 2opxA-3kosA:
undetectable		 2opxA-3kosA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		4 / 6 LEU A 109
GLY A 107
LEU A 113
SER A 114
 None
 0.89A 3aiaA-3kosA:
undetectable		 3aiaA-3kosA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.36A 5eeuG-3kosA:
undetectable
5eeuH-3kosA:
undetectable		 5eeuG-3kosA:
15.42
5eeuH-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.36A 5eevG-3kosA:
undetectable
5eevH-3kosA:
undetectable		 5eevG-3kosA:
15.42
5eevH-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.36A 5eewG-3kosA:
undetectable
5eewH-3kosA:
undetectable		 5eewG-3kosA:
15.42
5eewH-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.36A 5eexG-3kosA:
undetectable
5eexH-3kosA:
undetectable		 5eexG-3kosA:
15.42
5eexH-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 11 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.34A 5eexI-3kosA:
undetectable
5eexJ-3kosA:
undetectable		 5eexI-3kosA:
15.42
5eexJ-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.35A 5eexA-3kosA:
undetectable
5eexK-3kosA:
undetectable		 5eexA-3kosA:
15.42
5eexK-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.36A 5eeyG-3kosA:
undetectable
5eeyH-3kosA:
undetectable		 5eeyG-3kosA:
15.42
5eeyH-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 11 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.35A 5eeyI-3kosA:
undetectable
5eeyJ-3kosA:
undetectable		 5eeyI-3kosA:
15.42
5eeyJ-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.36A 5eezG-3kosA:
undetectable
5eezH-3kosA:
undetectable		 5eezG-3kosA:
15.42
5eezH-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 11 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.34A 5eezI-3kosA:
undetectable
5eezJ-3kosA:
undetectable		 5eezI-3kosA:
15.42
5eezJ-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.36A 5ef0G-3kosA:
undetectable
5ef0H-3kosA:
undetectable		 5ef0G-3kosA:
15.42
5ef0H-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 11 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.34A 5ef0I-3kosA:
undetectable
5ef0J-3kosA:
undetectable		 5ef0I-3kosA:
15.42
5ef0J-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.35A 5ef0A-3kosA:
undetectable
5ef0K-3kosA:
undetectable		 5ef0A-3kosA:
15.42
5ef0K-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.36A 5ef1G-3kosA:
undetectable
5ef1H-3kosA:
undetectable		 5ef1G-3kosA:
15.42
5ef1H-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 11 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.34A 5ef1I-3kosA:
undetectable
5ef1J-3kosA:
undetectable		 5ef1I-3kosA:
15.42
5ef1J-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.36A 5ef2G-3kosA:
undetectable
5ef2H-3kosA:
undetectable		 5ef2G-3kosA:
15.42
5ef2H-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 11 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.34A 5ef2I-3kosA:
undetectable
5ef2J-3kosA:
undetectable		 5ef2I-3kosA:
15.42
5ef2J-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.36A 5ef3G-3kosA:
undetectable
5ef3H-3kosA:
undetectable		 5ef3G-3kosA:
15.42
5ef3H-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 11 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.34A 5ef3I-3kosA:
undetectable
5ef3J-3kosA:
undetectable		 5ef3I-3kosA:
15.42
5ef3J-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		5 / 10 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.35A 5ef3A-3kosA:
undetectable
5ef3K-3kosA:
undetectable		 5ef3A-3kosA:
15.42
5ef3K-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		4 / 5 CYH A 169
GLN A 253
PRO A 254
ILE A 183
 None
 1.40A 5ki6A-3kosA:
undetectable		 5ki6A-3kosA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM7_A_ACTA603_0
(SALICYLATE-AMP
LIGASE)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		4 / 4 THR A 155
THR A 267
ALA A 157
ARG A 146
 None
 1.23A 5wm7A-3kosA:
undetectable		 5wm7A-3kosA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR
(Citrobacter
freundii) 		4 / 4 GLY A  99
LEU A 141
VAL A 134
GLU A 139
 None
None
GOL  A   4 ( 4.9A)
GOL  A   4 (-3.2A)
 1.44A 5yw0A-3kosA:
undetectable		 5yw0A-3kosA:
22.67