SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kpa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3kpa PROBABLE UBIQUITIN
FOLD MODIFIER
CONJUGATING ENZYME
(Leishmania
major) 		4 / 6 PRO A  13
HIS A 135
LEU A  15
ALA A  36
 None
 1.19A 3gv1A-3kpaA:
undetectable
3gv1C-3kpaA:
undetectable		 3gv1A-3kpaA:
18.93
3gv1C-3kpaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3kpa PROBABLE UBIQUITIN
FOLD MODIFIER
CONJUGATING ENZYME
(Leishmania
major) 		4 / 6 LEU A  15
ALA A  36
PRO A  13
HIS A 135
 None
 1.23A 3gv1A-3kpaA:
undetectable
3gv1B-3kpaA:
undetectable		 3gv1A-3kpaA:
18.93
3gv1B-3kpaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3kpa PROBABLE UBIQUITIN
FOLD MODIFIER
CONJUGATING ENZYME
(Leishmania
major) 		4 / 4 SER A 134
ILE A  96
TYR A  41
PRO A  94
 None
 1.30A 4lc4A-3kpaA:
0.0		 4lc4A-3kpaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3kpa PROBABLE UBIQUITIN
FOLD MODIFIER
CONJUGATING ENZYME
(Leishmania
major) 		4 / 4 SER A 134
ILE A  96
TYR A  41
PRO A  94
 None
 1.30A 4lc4B-3kpaA:
undetectable		 4lc4B-3kpaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3kpa PROBABLE UBIQUITIN
FOLD MODIFIER
CONJUGATING ENZYME
(Leishmania
major) 		4 / 5 ILE A 114
LEU A  98
GLU A 148
VAL A 153
 None
 0.88A 4nkxB-3kpaA:
undetectable		 4nkxB-3kpaA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3kpa PROBABLE UBIQUITIN
FOLD MODIFIER
CONJUGATING ENZYME
(Leishmania
major) 		5 / 12 GLY A 140
LEU A 145
SER A 146
ILE A  96
HIS A 135
 None
 1.02A 5dpdA-3kpaA:
undetectable		 5dpdA-3kpaA:
12.43