SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kpb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 434
ASP A 439
VAL A 459
ILE A 460
PRO A 484
 SAM  A1000 ( 4.2A)
SAM  A1000 (-2.6A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
None
 1.12A 2yzqA-3kpbA:
13.5		 2yzqA-3kpbA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		6 / 12 ILE A 434
THR A 456
VAL A 459
ILE A 460
ILE A 480
PRO A 484
 SAM  A1000 ( 4.2A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
SAM  A1000 (-4.0A)
None
 0.54A 2yzqA-3kpbA:
13.5		 2yzqA-3kpbA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 495
ALA A 462
VAL A 459
PRO A 423
LEU A 431
 None
None
SAM  A1000 ( 3.9A)
None
None
 0.99A 3a51E-3kpbA:
undetectable		 3a51E-3kpbA:
14.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		12 / 12 ASN A 420
ILE A 434
THR A 436
TRP A 438
ASP A 439
LYS A 442
THR A 456
VAL A 459
ILE A 460
ILE A 480
SER A 481
PRO A 484
 SAM  A1000 (-4.4A)
SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 (-3.1A)
SAM  A1000 (-2.6A)
SAM  A1000 ( 3.7A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
SAM  A1000 (-4.0A)
SAM  A1000 (-3.2A)
None
 0.01A 3kpbA-3kpbA:
26.9		 3kpbA-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		6 / 12 ILE A 495
THR A 497
ASP A 500
ILE A 399
ILE A 419
PRO A 423
 None
 0.63A 3kpbA-3kpbA:
26.9		 3kpbA-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		12 / 12 HIS A 421
ILE A 434
THR A 436
TRP A 438
ASP A 439
LYS A 442
THR A 456
VAL A 459
ILE A 460
ILE A 480
SER A 481
PRO A 484
 None
SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 (-3.1A)
SAM  A1000 (-2.6A)
SAM  A1000 ( 3.7A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
SAM  A1000 (-4.0A)
SAM  A1000 (-3.2A)
None
 0.22A 3kpbC-3kpbA:
24.6		 3kpbC-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		7 / 12 HIS A 421
ILE A 495
THR A 497
ASP A 500
ILE A 399
ILE A 419
PRO A 423
 None
 0.81A 3kpbC-3kpbA:
24.6		 3kpbC-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		10 / 10 ILE A 434
THR A 436
TRP A 438
ASP A 439
LYS A 442
THR A 456
VAL A 459
ILE A 460
ILE A 480
SER A 481
 SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 (-3.1A)
SAM  A1000 (-2.6A)
SAM  A1000 ( 3.7A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
SAM  A1000 (-4.0A)
SAM  A1000 (-3.2A)
 0.22A 3kpbD-3kpbA:
24.0		 3kpbD-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 495
THR A 497
ASP A 500
ILE A 399
ILE A 419
 None
 0.66A 3kpbD-3kpbA:
24.0		 3kpbD-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		10 / 11 ILE A 434
THR A 436
ASP A 439
THR A 456
VAL A 459
ILE A 460
ASN A 479
ILE A 480
SER A 481
PRO A 484
 SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 (-2.6A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
None
SAM  A1000 (-4.0A)
SAM  A1000 (-3.2A)
None
 0.75A 3kpcA-3kpbA:
21.3		 3kpcA-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		7 / 11 ILE A 495
THR A 497
ASP A 500
ILE A 399
ASN A 418
ILE A 419
PRO A 423
 None
 0.79A 3kpcA-3kpbA:
21.3		 3kpcA-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		10 / 12 ILE A 434
THR A 436
ASP A 439
LYS A 442
THR A 456
VAL A 459
ILE A 460
ASN A 479
ILE A 480
PRO A 484
 SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 (-2.6A)
SAM  A1000 ( 3.7A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
None
SAM  A1000 (-4.0A)
None
 0.80A 3kpdB-3kpbA:
21.9		 3kpdB-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		9 / 12 ILE A 434
THR A 436
TRP A 438
ASP A 439
LYS A 442
THR A 456
VAL A 459
ILE A 460
PRO A 484
 SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 (-3.1A)
SAM  A1000 (-2.6A)
SAM  A1000 ( 3.7A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
None
 0.80A 3kpdB-3kpbA:
21.9		 3kpdB-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		8 / 12 ILE A 434
THR A 436
VAL A 459
ILE A 460
ASN A 479
ILE A 480
SER A 481
PRO A 484
 SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
None
SAM  A1000 (-4.0A)
SAM  A1000 (-3.2A)
None
 0.68A 3kpdB-3kpbA:
21.9		 3kpdB-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		7 / 12 ILE A 495
THR A 497
ASP A 500
ILE A 399
ASN A 418
ILE A 419
PRO A 423
 None
 0.76A 3kpdB-3kpbA:
21.9		 3kpdB-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		11 / 12 ILE A 434
THR A 436
ASP A 439
THR A 456
VAL A 459
ILE A 460
ASN A 479
ILE A 480
SER A 481
VAL A 483
PRO A 484
 SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 (-2.6A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
None
SAM  A1000 (-4.0A)
SAM  A1000 (-3.2A)
SAM  A1000 ( 4.4A)
None
 0.66A 3kpdC-3kpbA:
21.5		 3kpdC-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		7 / 12 ILE A 434
THR A 436
TRP A 438
ASP A 439
THR A 456
ILE A 460
ASN A 479
 SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 (-3.1A)
SAM  A1000 (-2.6A)
SAM  A1000 (-3.0A)
SAM  A1000 (-3.8A)
None
 0.98A 3kpdC-3kpbA:
21.5		 3kpdC-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		7 / 12 ILE A 495
THR A 497
ASP A 500
ILE A 399
ASN A 418
ILE A 419
PRO A 423
 None
 0.86A 3kpdC-3kpbA:
21.5		 3kpdC-3kpbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 401
ILE A 435
GLY A 433
VAL A 432
ILE A 405
 None
 1.10A 3oxvB-3kpbA:
undetectable		 3oxvB-3kpbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3kpb UNCHARACTERIZED
PROTEIN MJ0100
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 426
ARG A 491
LYS A 430
 None
 0.98A 3wipG-3kpbA:
undetectable		 3wipG-3kpbA:
22.81