SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kpx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		3 / 3 TRP A  21
ARG A 115
THR A 184
 None
 0.84A 1df7A-3kpxA:
undetectable		 1df7A-3kpxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		4 / 6 TYR A 193
ILE A 133
TYR A 141
GLY A 142
 None
None
CZH  A 201 (-4.6A)
None
 1.03A 1maaB-3kpxA:
undetectable
1maaD-3kpxA:
undetectable		 1maaB-3kpxA:
15.40
1maaD-3kpxA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		5 / 12 TYR A 193
ALA A 189
GLY A 191
ARG A 176
HIS A 178
 None
None
None
None
CZH  A 201 (-3.3A)
 1.07A 1ve3B-3kpxA:
undetectable		 1ve3B-3kpxA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		4 / 6 THR A 140
GLU A 137
PHE A 122
ILE A 124
 None
None
CZH  A 201 (-4.6A)
None
 1.16A 2w98B-3kpxA:
undetectable		 2w98B-3kpxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		3 / 3 ARG A 176
ARG A 115
TRP A 106
 None
 1.19A 4b7nA-3kpxA:
undetectable		 4b7nA-3kpxA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		3 / 3 ARG A 176
ARG A 115
TRP A 106
 None
 1.13A 4cpzE-3kpxA:
undetectable		 4cpzE-3kpxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		3 / 3 ARG A 176
ARG A 115
TRP A 106
 None
 1.19A 4cpzG-3kpxA:
undetectable		 4cpzG-3kpxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		3 / 3 TRP A  21
GLN A 177
THR A 184
 None
 0.89A 4m2xA-3kpxA:
undetectable		 4m2xA-3kpxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		4 / 6 PHE A  91
HIS A  25
TYR A 183
PHE A  74
 CZH  A 201 (-4.2A)
CZH  A 201 (-3.8A)
None
None
 1.46A 4o7gB-3kpxA:
undetectable		 4o7gB-3kpxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		3 / 3 TRP A 117
ILE A 147
SER A 145
 CZH  A 201 (-3.8A)
CZH  A 201 (-4.1A)
CZH  A 201 ( 4.5A)
 1.03A 5gqbA-3kpxA:
undetectable		 5gqbA-3kpxA:
16.27