SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		5 / 11 LEU A 275
ASN A 217
ILE A 219
THR A 249
PHE A 262
 None
 1.43A 1tw4A-3kq4A:
undetectable		 1tw4A-3kq4A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3kq4 CUBILIN
(Homo
sapiens) 		5 / 11 PHE B1270
PHE B1210
PHE B1207
LEU B1205
PHE B1176
 None
 0.94A 1z11A-3kq4B:
undetectable		 1z11A-3kq4B:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3kq4 CUBILIN
(Homo
sapiens) 		5 / 11 PHE B1270
PHE B1210
PHE B1207
LEU B1205
PHE B1176
 None
 0.93A 1z11B-3kq4B:
undetectable		 1z11B-3kq4B:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3kq4 CUBILIN
(Homo
sapiens) 		3 / 3 PHE B1176
PHE B1270
PHE B1207
 None
 0.84A 2od9A-3kq4B:
undetectable		 2od9A-3kq4B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3kq4 CUBILIN
(Homo
sapiens) 		4 / 7 ALA B1031
TYR B1032
ASP B 988
HIS B 954
 None
None
CA  B2014 (-3.2A)
None
 1.46A 2pncA-3kq4B:
undetectable		 2pncA-3kq4B:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3kq4 CUBILIN
(Homo
sapiens) 		3 / 3 PHE B1176
PHE B1270
PHE B1207
 None
 0.84A 2qqgA-3kq4B:
undetectable		 2qqgA-3kq4B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		4 / 7 PRO A 188
LEU A 151
ALA A 154
PHE A 199
 None
 0.82A 2vcvA-3kq4A:
2.4		 2vcvA-3kq4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		4 / 7 PRO A 188
LEU A 151
ALA A 154
PHE A 199
 None
 0.88A 2vcvG-3kq4A:
2.8		 2vcvG-3kq4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		4 / 7 PRO A 188
LEU A 151
ALA A 154
PHE A 199
 None
 0.98A 2vcvL-3kq4A:
2.2		 2vcvL-3kq4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		4 / 8 PRO A 188
LEU A 151
ALA A 154
PHE A 199
 None
 0.85A 2vcvP-3kq4A:
undetectable		 2vcvP-3kq4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		4 / 7 GLY A 173
ALA A 174
MET A 175
LEU A 178
 None
 0.52A 2wekB-3kq4A:
undetectable		 2wekB-3kq4A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 3kq4 CUBILIN
(Homo
sapiens) 		5 / 12 PRO B1179
LEU B1085
ILE B1086
ALA B1087
LEU B1120
 None
 1.10A 3a50A-3kq4B:
undetectable		 3a50A-3kq4B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		4 / 7 VAL A 346
LEU A 347
ILE A 333
ASN A 334
 None
 1.03A 3avpA-3kq4A:
undetectable		 3avpA-3kq4A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		4 / 5 LEU A  99
GLN A  78
THR A  76
LEU A  87
 None
 1.19A 3ce6D-3kq4A:
undetectable		 3ce6D-3kq4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		5 / 11 ILE A 210
LEU A 233
SER A 234
VAL A 235
ALA A 232
 None
 0.96A 3dcmX-3kq4A:
undetectable		 3dcmX-3kq4A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 3kq4 CUBILIN
(Homo
sapiens) 		5 / 11 SER B1233
LEU B1205
SER B1250
ILE B1257
SER B1254
 None
 1.49A 3h6tA-3kq4B:
undetectable
3h6tC-3kq4B:
undetectable		 3h6tA-3kq4B:
20.00
3h6tC-3kq4B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		5 / 12 LEU A  94
THR A  95
ALA A  98
LEU A  75
LEU A  58
 None
 1.07A 3hm1A-3kq4A:
undetectable		 3hm1A-3kq4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3kq4 CUBILIN
GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		4 / 5 SER A 123
ARG B1377
GLY B1376
GLU B1379
 None
None
CA  B2017 ( 4.4A)
None
 1.31A 3k9fA-3kq4A:
undetectable
3k9fB-3kq4A:
undetectable
3k9fC-3kq4A:
undetectable		 3k9fA-3kq4A:
21.77
3k9fB-3kq4A:
21.77
3k9fC-3kq4A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kq4 CUBILIN
(Homo
sapiens) 		6 / 12 LEU B1085
ASP B1111
PRO B1118
GLY B1167
LEU B1195
ILE B1257
 None
None
None
NAG  B2007 ( 3.9A)
None
None
 1.24A 3ku1C-3kq4B:
undetectable		 3ku1C-3kq4B:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3kq4 CUBILIN
(Homo
sapiens) 		5 / 11 PHE B1270
PHE B1210
PHE B1207
LEU B1205
PHE B1176
 None
 1.13A 3t3rA-3kq4B:
undetectable		 3t3rA-3kq4B:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3kq4 CUBILIN
(Homo
sapiens) 		3 / 3 ASP B1221
GLU B1263
GLY B1264
 CA  B2016 (-2.2A)
None
CA  B2016 (-4.3A)
 0.62A 3w9tA-3kq4B:
undetectable		 3w9tA-3kq4B:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		5 / 12 LEU A 137
LEU A 140
ALA A 141
GLN A 144
ALA A  98
 None
 0.92A 4fn9A-3kq4A:
undetectable		 4fn9A-3kq4A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		5 / 12 LEU A 137
LEU A 140
ALA A 141
GLN A 144
THR A  88
 None
 0.86A 4fn9B-3kq4A:
undetectable		 4fn9B-3kq4A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3kq4 CUBILIN
(Homo
sapiens) 		4 / 8 PHE B 974
LEU B1022
VAL B 992
ILE B1009
 None
 0.86A 4l4cB-3kq4B:
undetectable		 4l4cB-3kq4B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 3kq4 CUBILIN
(Homo
sapiens) 		4 / 7 ASN B1066
PRO B1065
PHE B1064
PHE B1143
 None
NAG  B2002 (-4.5A)
NAG  B2002 ( 4.8A)
None
 1.48A 4v32C-3kq4B:
undetectable		 4v32C-3kq4B:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 3kq4 CUBILIN
(Homo
sapiens) 		4 / 8 SER B1189
TRP B1193
ILE B1257
GLY B1166
 None
 0.80A 5alcL-3kq4B:
undetectable		 5alcL-3kq4B:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		4 / 4 LEU A 272
TYR A 224
PRO A 265
ILE A  57
 None
B12  A2007 (-3.5A)
None
None
 1.28A 5esgA-3kq4A:
undetectable		 5esgA-3kq4A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		4 / 5 GLY A 391
THR A 393
GLN A 387
THR A 411
 None
None
NAG  A2002 ( 4.8A)
None
 1.03A 5h5fA-3kq4A:
undetectable		 5h5fA-3kq4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens) 		4 / 7 TYR A 195
ILE A 187
GLY A 200
PHE A 199
 None
 0.87A 5nooB-3kq4A:
undetectable		 5nooB-3kq4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3kq4 CUBILIN
(Homo
sapiens) 		3 / 3 VAL B1318
VAL B1388
GLN B1286
 None
 0.67A 5qguA-3kq4B:
undetectable		 5qguA-3kq4B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3kq4 CUBILIN
(Homo
sapiens) 		3 / 3 VAL B1318
VAL B1388
GLN B1286
 None
 0.71A 5qh9A-3kq4B:
undetectable		 5qh9A-3kq4B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3kq4 CUBILIN
(Homo
sapiens) 		3 / 3 VAL B1318
VAL B1388
GLN B1286
 None
 0.71A 5qhcA-3kq4B:
undetectable		 5qhcA-3kq4B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3kq4 CUBILIN
(Homo
sapiens) 		3 / 3 VAL B1318
VAL B1388
GLN B1286
 None
 0.71A 5qheA-3kq4B:
undetectable		 5qheA-3kq4B:
17.53