SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		3 / 3 PHE A 218
LEU A 207
SER A 115
 None
 0.85A 1e7aA-3kq5A:
undetectable		 1e7aA-3kq5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		5 / 12 PHE A 132
LEU A 287
PHE A 293
GLY A 315
GLY A 325
 None
 1.10A 1fe2A-3kq5A:
undetectable		 1fe2A-3kq5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 4 GLY A 117
LEU A 120
GLY A  87
ARG A  90
 None
 1.28A 1j7kA-3kq5A:
undetectable		 1j7kA-3kq5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 4 GLY A 117
LEU A 120
GLY A  91
ARG A  90
 None
 1.11A 1j7kA-3kq5A:
undetectable		 1j7kA-3kq5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		5 / 9 LEU A 366
LEU A 287
ILE A 367
PHE A 314
LEU A 320
 None
 1.27A 2f78A-3kq5A:
undetectable		 2f78A-3kq5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		5 / 9 LEU A 366
LEU A 287
ILE A 367
PHE A 314
LEU A 320
 None
 1.25A 2f78B-3kq5A:
undetectable		 2f78B-3kq5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		5 / 10 LEU A 118
GLY A 117
LEU A 120
LEU A 119
LEU A  83
 None
 0.94A 2f8dA-3kq5A:
undetectable		 2f8dA-3kq5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		5 / 10 LEU A 118
GLY A 117
LEU A 120
LEU A 119
LEU A  83
 None
 0.95A 2f8dB-3kq5A:
undetectable		 2f8dB-3kq5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 7 ILE A 367
LEU A 320
GLY A 319
PHE A 318
 None
 0.76A 2tsrA-3kq5A:
undetectable		 2tsrA-3kq5A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		5 / 12 ILE A 367
LEU A 257
PHE A 256
LEU A 264
ILE A 292
 None
 1.09A 2w3vA-3kq5A:
undetectable		 2w3vA-3kq5A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 8 ALA A 239
LEU A 240
TYR A  16
ILE A 131
 None
 0.70A 3cldB-3kq5A:
undetectable		 3cldB-3kq5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 6 VAL A  69
VAL A  24
ILE A 131
ARG A  64
 None
 1.09A 3pyyA-3kq5A:
undetectable		 3pyyA-3kq5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		5 / 9 LEU A  80
ILE A 131
ILE A 133
PHE A  25
VAL A  24
 None
 1.49A 3tmzA-3kq5A:
undetectable		 3tmzA-3kq5A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		5 / 9 LEU A 244
ILE A 131
ILE A 133
PHE A  25
VAL A  24
 None
 1.35A 3tmzA-3kq5A:
undetectable		 3tmzA-3kq5A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 7 LEU A 257
ALA A 253
THR A 250
SER A 247
 None
 1.04A 4ikjA-3kq5A:
undetectable
4ikjB-3kq5A:
undetectable		 4ikjA-3kq5A:
13.45
4ikjB-3kq5A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 7 SER A 247
LEU A 257
ALA A 253
THR A 250
 None
 1.05A 4ikkA-3kq5A:
undetectable
4ikkB-3kq5A:
undetectable		 4ikkA-3kq5A:
13.45
4ikkB-3kq5A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 7 ILE A 367
LEU A 320
GLY A 319
PHE A 318
 None
 0.72A 4iqqA-3kq5A:
undetectable		 4iqqA-3kq5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 7 ILE A 367
LEU A 320
GLY A 319
PHE A 318
 None
 0.79A 4iqqC-3kq5A:
undetectable		 4iqqC-3kq5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 8 ILE A 367
LEU A 320
GLY A 319
PHE A 318
 None
 0.81A 4iqqD-3kq5A:
undetectable		 4iqqD-3kq5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		5 / 12 LEU A 260
ILE A 292
LEU A 287
VAL A 285
VAL A 280
 None
 0.99A 4nkvB-3kq5A:
undetectable		 4nkvB-3kq5A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		5 / 12 TYR A 311
VAL A 285
LEU A 333
ALA A 253
PHE A 256
 None
 1.32A 4rtbA-3kq5A:
undetectable		 4rtbA-3kq5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		5 / 12 TYR A 311
VAL A 285
LEU A 333
LEU A 307
PHE A 256
 None
 1.41A 4rtbA-3kq5A:
undetectable		 4rtbA-3kq5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		3 / 3 ASN A 272
LEU A 264
PHE A 286
 None
 0.79A 5dsgA-3kq5A:
2.3		 5dsgA-3kq5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 7 PHE A 225
ILE A 230
GLY A  91
LEU A  39
 None
 0.97A 5esmA-3kq5A:
undetectable		 5esmA-3kq5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 7 ILE A 367
LEU A 320
GLY A 315
PHE A 314
 None
 0.83A 5h3aB-3kq5A:
undetectable		 5h3aB-3kq5A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 7 ILE A 367
LEU A 320
GLY A 319
PHE A 318
 None
 0.73A 5h3aB-3kq5A:
undetectable		 5h3aB-3kq5A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 7 ILE A 367
LEU A 320
GLY A 319
PHE A 318
 None
 0.75A 5nooA-3kq5A:
undetectable		 5nooA-3kq5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		4 / 8 ILE A 176
PHE A 147
ASN A 145
PHE A  68
 None
 1.12A 5x23A-3kq5A:
undetectable		 5x23A-3kq5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN
(Coxiella
burnetii) 		3 / 3 VAL A 127
ALA A 123
GLN A 170
 None
 0.67A 6gb9A-3kq5A:
undetectable		 6gb9A-3kq5A:
21.68