SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kr9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 11 HIS A  62
ALA A  27
SER A  24
VAL A  34
ILE A   2
 None
 1.29A 2uxpB-3kr9A:
undetectable		 2uxpB-3kr9A:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		11 / 12 ARG A   5
GLY A  23
VAL A  47
PRO A  51
ASN A  74
GLY A  75
ALA A  91
GLY A  92
MET A  93
LEU A  97
ILE A 101
 None
 0.64A 3ku1A-3kr9A:
35.0		 3ku1A-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		11 / 12 LEU A   6
GLY A  23
VAL A  47
PRO A  51
ASN A  74
GLY A  75
ALA A  91
GLY A  92
MET A  93
LEU A  97
ILE A 101
 None
 0.50A 3ku1A-3kr9A:
35.0		 3ku1A-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		6 / 12 LEU A  29
PRO A  51
ALA A  91
MET A  93
LEU A  97
ILE A 101
 None
 1.47A 3ku1A-3kr9A:
35.0		 3ku1A-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		10 / 12 ARG A   5
GLY A  23
VAL A  47
PRO A  51
GLY A  75
ALA A  91
GLY A  92
MET A  93
LEU A  97
ILE A 101
 None
 0.66A 3ku1C-3kr9A:
34.8		 3ku1C-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		8 / 12 GLY A  23
ASP A  25
GLY A  75
ALA A  91
GLY A  92
MET A  93
LEU A  97
ILE A 101
 None
 1.01A 3ku1C-3kr9A:
34.8		 3ku1C-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		10 / 12 LEU A   6
GLY A  23
VAL A  47
PRO A  51
GLY A  75
ALA A  91
GLY A  92
MET A  93
LEU A  97
ILE A 101
 None
 0.43A 3ku1C-3kr9A:
34.8		 3ku1C-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		6 / 12 LEU A  29
PRO A  51
ALA A  91
MET A  93
LEU A  97
ILE A 101
 None
 1.47A 3ku1C-3kr9A:
34.8		 3ku1C-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		9 / 12 ARG A   5
ASP A  25
VAL A  47
ASN A  74
GLY A  75
ALA A  91
GLY A  92
LEU A  97
ILE A 101
 None
 0.73A 3ku1G-3kr9A:
34.9		 3ku1G-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		9 / 12 ARG A   5
VAL A  47
PRO A  51
ASN A  74
GLY A  75
ALA A  91
GLY A  92
LEU A  97
ILE A 101
 None
 0.64A 3ku1G-3kr9A:
34.9		 3ku1G-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		9 / 12 GLY A  23
ASP A  25
VAL A  47
ASN A  74
GLY A  75
ALA A  91
GLY A  92
LEU A  97
ILE A 101
 None
 0.60A 3ku1G-3kr9A:
34.9		 3ku1G-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A  45
VAL A  47
ASN A  74
GLY A  75
ILE A 101
 None
 1.05A 3ku1G-3kr9A:
34.9		 3ku1G-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		10 / 12 LEU A   6
GLY A  23
VAL A  47
PRO A  51
ASN A  74
GLY A  75
ALA A  91
GLY A  92
LEU A  97
ILE A 101
 None
 0.50A 3ku1G-3kr9A:
34.9		 3ku1G-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		9 / 12 ARG A   5
GLY A  23
ASP A  25
VAL A  48
GLY A  75
ALA A  91
MET A  93
LEU A  97
ILE A 101
 None
 0.93A 3ku1H-3kr9A:
34.9		 3ku1H-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		10 / 12 ARG A   5
GLY A  23
VAL A  47
VAL A  48
PRO A  51
GLY A  75
ALA A  91
MET A  93
LEU A  97
ILE A 101
 None
 0.71A 3ku1H-3kr9A:
34.9		 3ku1H-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		10 / 12 LEU A   6
GLY A  23
VAL A  47
VAL A  48
PRO A  51
GLY A  75
ALA A  91
MET A  93
LEU A  97
ILE A 101
 None
 0.47A 3ku1H-3kr9A:
34.9		 3ku1H-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		6 / 12 LEU A  29
PRO A  51
ALA A  91
MET A  93
LEU A  97
ILE A 101
 None
 1.44A 3ku1H-3kr9A:
34.9		 3ku1H-3kr9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 11 THR A  89
LEU A   6
GLU A   7
LEU A  19
VAL A  34
 None
 1.37A 3tbgA-3kr9A:
undetectable		 3tbgA-3kr9A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 10 THR A  89
LEU A   6
GLU A   7
LEU A  19
VAL A  34
 None
 1.36A 3tbgC-3kr9A:
undetectable		 3tbgC-3kr9A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 GLY A  16
ILE A  18
VAL A  13
SER A  86
 None
 1.25A 4d33A-3kr9A:
undetectable		 4d33A-3kr9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 GLY A  16
ILE A  18
VAL A  13
SER A  86
 None
 1.26A 4d33B-3kr9A:
undetectable		 4d33B-3kr9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 SER A   3
ARG A   5
LEU A   6
ASP A  25
 None
 1.45A 4ifxA-3kr9A:
0.3		 4ifxA-3kr9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 SER A   3
ARG A   5
LEU A   6
ASP A  25
 None
 1.46A 4ig1A-3kr9A:
undetectable		 4ig1A-3kr9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 3kr9 SAM-DEPENDENT
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 9 PHE A  79
ARG A  71
ALA A  78
ALA A  73
LEU A  76
 None
 1.39A 4or0A-3kr9A:
undetectable		 4or0A-3kr9A:
19.66