SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3krb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		3 / 3 ASP A 302
LYS A 308
ARG A 125
 None
 1.18A 1ra8A-3krbA:
undetectable		 1ra8A-3krbA:
16.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 12 TRP A  73
HIS A 104
GLU A 179
TYR A 203
SER A 204
 None
UNX  A 402 (-4.1A)
None
NAP  A 400 (-3.2A)
NAP  A 400 (-2.6A)
 0.27A 1s2aA-3krbA:
39.8		 1s2aA-3krbA:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 6 THR A  69
ASP A  35
SER A 259
VAL A 200
 None
NAP  A 400 (-3.7A)
None
None
 1.29A 2hdnI-3krbA:
undetectable
2hdnJ-3krbA:
undetectable
2hdnL-3krbA:
2.0		 2hdnI-3krbA:
7.86
2hdnJ-3krbA:
20.54
2hdnL-3krbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 6 SER A 259
VAL A 200
THR A  69
ASP A  35
 None
None
None
NAP  A 400 (-3.7A)
 1.24A 2hdnJ-3krbA:
undetectable
2hdnK-3krbA:
undetectable
2hdnL-3krbA:
2.0		 2hdnJ-3krbA:
20.54
2hdnK-3krbA:
7.86
2hdnL-3krbA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2INE_A_PACA317_0
(ALDOSE REDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 5 TRP A  12
VAL A  39
TYR A  40
HIS A 104
TRP A 105
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
NAP  A 400 ( 4.3A)
 0.21A 2ineA-3krbA:
41.1		 2ineA-3krbA:
40.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ISF_A_PACA317_0
(ALDOSE REDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 5 TRP A  12
VAL A  39
TYR A  40
HIS A 104
TRP A 105
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
NAP  A 400 ( 4.3A)
 0.24A 2isfA-3krbA:
40.9		 2isfA-3krbA:
40.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 11 TYR A  40
ASP A  35
VAL A  19
ILE A  46
VAL A  66
 UNX  A 402 (-4.4A)
NAP  A 400 (-3.7A)
None
None
None
 1.41A 2vcdA-3krbA:
undetectable		 2vcdA-3krbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 8 GLY A  47
ILE A  34
VAL A  23
VAL A  19
 None
 0.81A 3fi0B-3krbA:
undetectable		 3fi0B-3krbA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 8 GLY A  47
ILE A  34
VAL A  23
VAL A  19
 None
 0.74A 3fi0G-3krbA:
undetectable		 3fi0G-3krbA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 8 GLY A  47
ILE A  34
VAL A  23
VAL A  19
 None
 0.79A 3fi0I-3krbA:
undetectable		 3fi0I-3krbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 8 GLY A  47
ILE A  34
VAL A  23
VAL A  19
 None
 0.74A 3fi0Q-3krbA:
undetectable		 3fi0Q-3krbA:
22.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 12 TYR A  40
TRP A  73
HIS A 104
ASN A 156
TYR A 203
 UNX  A 402 (-4.4A)
None
UNX  A 402 (-4.1A)
NAP  A 400 (-3.4A)
NAP  A 400 (-3.2A)
 0.32A 3r43A-3krbA:
38.6		 3r43A-3krbA:
36.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 12 TYR A  40
TRP A  73
HIS A 104
TYR A 203
PHE A 306
 UNX  A 402 (-4.4A)
None
UNX  A 402 (-4.1A)
NAP  A 400 (-3.2A)
None
 1.05A 3r43A-3krbA:
38.6		 3r43A-3krbA:
36.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 12 TYR A  40
TRP A  73
HIS A 104
ASN A 156
TYR A 203
 UNX  A 402 (-4.4A)
None
UNX  A 402 (-4.1A)
NAP  A 400 (-3.4A)
NAP  A 400 (-3.2A)
 0.29A 3r6iA-3krbA:
37.5		 3r6iA-3krbA:
36.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 12 TYR A  40
TRP A  73
HIS A 104
TYR A 203
PHE A 306
 UNX  A 402 (-4.4A)
None
UNX  A 402 (-4.1A)
NAP  A 400 (-3.2A)
None
 1.00A 3r6iA-3krbA:
37.5		 3r6iA-3krbA:
36.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RX3_A_SUZA317_1
(ALDOSE REDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		6 / 10 TRP A  12
VAL A  39
TYR A  40
HIS A 104
PHE A 118
CYH A 301
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
None
NAP  A 400 ( 4.0A)
 1.11A 3rx3A-3krbA:
41.3		 3rx3A-3krbA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RX3_A_SUZA317_1
(ALDOSE REDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		6 / 10 TRP A  12
VAL A  39
TYR A  40
HIS A 104
TRP A 105
CYH A 301
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
NAP  A 400 ( 4.3A)
NAP  A 400 ( 4.0A)
 0.50A 3rx3A-3krbA:
41.3		 3rx3A-3krbA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 7 TRP A  12
TYR A  40
HIS A 104
PHE A 118
CYH A 301
 UNX  A 402 (-4.3A)
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
None
NAP  A 400 ( 4.0A)
 1.19A 3s3gA-3krbA:
41.3		 3s3gA-3krbA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 7 TRP A  12
TYR A  40
HIS A 104
TRP A 105
CYH A 301
 UNX  A 402 (-4.3A)
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
NAP  A 400 ( 4.3A)
NAP  A 400 ( 4.0A)
 0.52A 3s3gA-3krbA:
41.3		 3s3gA-3krbA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U2C_A_SUZA2001_1
(ALDOSE REDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		6 / 9 TRP A  12
VAL A  39
TYR A  40
HIS A 104
PHE A 118
CYH A 301
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
None
NAP  A 400 ( 4.0A)
 1.05A 3u2cA-3krbA:
41.6		 3u2cA-3krbA:
40.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U2C_A_SUZA2001_1
(ALDOSE REDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		6 / 9 TRP A  12
VAL A  39
TYR A  40
HIS A 104
TRP A 105
CYH A 301
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
NAP  A 400 ( 4.3A)
NAP  A 400 ( 4.0A)
 0.55A 3u2cA-3krbA:
41.6		 3u2cA-3krbA:
40.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		6 / 12 TYR A  40
TRP A  73
HIS A 104
ASN A 156
TYR A 203
SER A 204
 UNX  A 402 (-4.4A)
None
UNX  A 402 (-4.1A)
NAP  A 400 (-3.4A)
NAP  A 400 (-3.2A)
NAP  A 400 (-2.6A)
 0.40A 3ug8A-3krbA:
37.7		 3ug8A-3krbA:
36.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 8 TRP A  12
TRP A  73
HIS A 104
PHE A 118
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.1A)
None
 1.28A 3v35A-3krbA:
41.5		 3v35A-3krbA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 8 TRP A  12
VAL A  39
TRP A  73
HIS A 104
TRP A 105
 UNX  A 402 (-4.3A)
None
None
UNX  A 402 (-4.1A)
NAP  A 400 ( 4.3A)
 0.32A 3v35A-3krbA:
41.5		 3v35A-3krbA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 8 VAL A  39
TRP A  73
HIS A 104
TRP A 105
PHE A 109
 None
None
UNX  A 402 (-4.1A)
NAP  A 400 ( 4.3A)
None
 1.23A 3v35A-3krbA:
41.5		 3v35A-3krbA:
40.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 11 GLN A  85
LEU A 143
PHE A 101
ASN A  76
VAL A 131
 None
 1.44A 4claA-3krbA:
undetectable		 4claA-3krbA:
18.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 8 VAL A  39
TYR A  40
TRP A  73
HIS A 104
 None
UNX  A 402 (-4.4A)
None
UNX  A 402 (-4.1A)
 0.48A 4jq1B-3krbA:
39.0		 4jq1B-3krbA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 8 VAL A  39
TYR A  40
TRP A  73
HIS A 104
 None
UNX  A 402 (-4.4A)
None
UNX  A 402 (-4.1A)
 0.25A 4jtrA-3krbA:
39.2		 4jtrA-3krbA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 6 VAL A  39
TYR A  40
TRP A  73
HIS A 104
 None
UNX  A 402 (-4.4A)
None
UNX  A 402 (-4.1A)
 0.26A 4jtrB-3krbA:
39.3		 4jtrB-3krbA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WEV_X_SUZX402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		6 / 10 TRP A  12
VAL A  39
TYR A  40
HIS A 104
PHE A 118
CYH A 301
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
None
NAP  A 400 ( 4.0A)
 0.65A 4wevX-3krbA:
40.2		 4wevX-3krbA:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		5 / 9 TYR A  40
TRP A  73
HIS A 104
ASN A 156
TYR A 203
 UNX  A 402 (-4.4A)
None
UNX  A 402 (-4.1A)
NAP  A 400 (-3.4A)
NAP  A 400 (-3.2A)
 0.29A 4yvvA-3krbA:
39.0		 4yvvA-3krbA:
36.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 7 ILE A 224
CYH A 227
LYS A 231
LEU A 230
 None
 0.78A 5a06A-3krbA:
undetectable		 5a06A-3krbA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 7 ILE A 224
CYH A 227
LYS A 231
LEU A 230
 None
 0.76A 5a06B-3krbA:
undetectable		 5a06B-3krbA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 7 ILE A 224
CYH A 227
LYS A 231
LEU A 230
 None
 0.78A 5a06C-3krbA:
undetectable		 5a06C-3krbA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 7 ILE A 224
CYH A 227
LYS A 231
LEU A 230
 None
 0.72A 5a06E-3krbA:
undetectable		 5a06E-3krbA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		4 / 7 ILE A 224
CYH A 227
LYS A 231
LEU A 230
 None
 0.79A 5a06F-3krbA:
undetectable		 5a06F-3krbA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		3 / 3 ILE A  53
ILE A  68
MET A  28
 None
 0.62A 5i9yA-3krbA:
undetectable		 5i9yA-3krbA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3krb ALDOSE REDUCTASE
(Giardia
intestinalis) 		3 / 3 THR A  29
PRO A   5
ARG A   6
 None
 0.78A 5nd7B-3krbA:
undetectable		 5nd7B-3krbA:
24.55