SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3krc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		5 / 12 GLY A 155
GLY A 151
GLU A 150
ILE A 176
HIS A 172
 None
 0.96A 2oxtC-3krcA:
undetectable		 2oxtC-3krcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		5 / 12 ALA A 109
GLY A 105
MET A  81
SER A  34
TYR A  37
 None
 1.43A 3bxoB-3krcA:
undetectable		 3bxoB-3krcA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		4 / 5 ASN A 100
ASP A  91
GLU A 163
SER A  38
 None
 1.41A 3p2kC-3krcA:
undetectable		 3p2kC-3krcA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		3 / 3 ARG A  36
GLU A  33
PHE A 104
 None
 0.92A 4kszA-3krcA:
undetectable		 4kszA-3krcA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		5 / 8 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
 None
 0.82A 4umjA-3krcA:
39.3		 4umjA-3krcA:
48.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		5 / 9 SER A  79
LEU A  80
ASP A  83
ASP A  89
THR A 181
 None
None
None
None
IPE  A 902 ( 3.7A)
 0.84A 4umjB-3krcA:
39.3		 4umjB-3krcA:
48.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		5 / 9 SER A  79
LEU A  80
ASP A  89
ARG A  94
THR A 181
 None
None
None
None
IPE  A 902 ( 3.7A)
 0.73A 4umjB-3krcA:
39.3		 4umjB-3krcA:
48.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		4 / 6 HIS A  76
GLY A  43
GLU A  73
ARG A  45
 IPE  A 902 (-4.3A)
IPE  A 902 (-3.6A)
IPE  A 902 ( 4.6A)
None
 1.17A 4zbqA-3krcA:
3.8		 4zbqA-3krcA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		5 / 12 GLU A 202
LYS A 199
GLY A  59
LEU A 195
ALA A 131
 None
 1.35A 5kbwA-3krcA:
undetectable		 5kbwA-3krcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		3 / 3 LEU A 272
ILE A 284
TYR A   7
 None
 0.66A 5uunB-3krcA:
undetectable		 5uunB-3krcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		4 / 8 MET A  49
MET A   8
TYR A   7
MET A   1
 None
 1.47A 5wqpA-3krcA:
undetectable		 5wqpA-3krcA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		4 / 6 LEU A  80
ASP A  83
ARG A  94
GLN A 156
 None
 1.34A 6g31J-3krcA:
21.7		 6g31J-3krcA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		4 / 6 LEU A  80
ASP A  83
ASP A  89
ARG A  94
 None
 1.15A 6g31J-3krcA:
21.7		 6g31J-3krcA:
15.21