SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Ehrlichia
chaffeensis) 		4 / 8 LEU A 148
ILE A 151
GLY A 181
LYS A 182
 None
 0.90A 3b9lA-3kreA:
undetectable		 3b9lA-3kreA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Ehrlichia
chaffeensis) 		5 / 9 ILE A  89
ILE A 151
LYS A 152
LEU A 148
GLU A 134
 None
 1.41A 3f78A-3kreA:
undetectable		 3f78A-3kreA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Ehrlichia
chaffeensis) 		4 / 6 ILE A 151
LEU A 191
GLU A 179
ALA A 194
 None
 0.89A 3r9sA-3kreA:
undetectable		 3r9sA-3kreA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Ehrlichia
chaffeensis) 		5 / 9 LEU A 191
LEU A 143
GLU A 149
PHE A 180
GLU A 134
 None
 1.48A 3tmzA-3kreA:
undetectable		 3tmzA-3kreA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Ehrlichia
chaffeensis) 		3 / 3 PHE A  28
SER A 198
SER A  54
 None
 0.82A 3ufgB-3kreA:
undetectable		 3ufgB-3kreA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Ehrlichia
chaffeensis) 		4 / 7 TYR A 229
VAL A 232
ILE A 171
GLU A 196
 None
 1.13A 4a97E-3kreA:
undetectable		 4a97E-3kreA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Ehrlichia
chaffeensis) 		4 / 4 LEU A  57
ILE A 197
PRO A 199
LEU A 204
 None
 1.20A 5eb3A-3kreA:
undetectable		 5eb3A-3kreA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Ehrlichia
chaffeensis) 		3 / 3 ARG A 203
ASN A 100
ASP A 129
 CL  A 400 ( 3.7A)
CL  A 400 (-4.8A)
EDO  A 302 (-3.9A)
 0.88A 5gwxA-3kreA:
undetectable		 5gwxA-3kreA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Ehrlichia
chaffeensis) 		5 / 12 LEU A  61
ILE A  66
GLY A  65
LEU A 162
SER A 163
 None
None
None
None
CL  A 401 ( 3.7A)
 1.13A 5twjC-3kreA:
undetectable		 5twjC-3kreA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Ehrlichia
chaffeensis) 		3 / 3 ILE A 117
ASN A 159
CYH A 202
 None
CL  A 401 ( 4.1A)
None
 0.80A 6bp4A-3kreA:
undetectable		 6bp4A-3kreA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Ehrlichia
chaffeensis) 		5 / 10 PHE A 166
LEU A 165
GLY A 170
ILE A 171
PHE A  56
 None
 1.08A 6ebpC-3kreA:
undetectable		 6ebpC-3kreA:
15.09