SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3krm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3krm INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 7 LEU A 513
VAL A 521
VAL A 494
ILE A 492
 None
 0.86A 1t87B-3krmA:
undetectable		 1t87B-3krmA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 3krm INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 12 VAL A 486
LEU A 488
ILE A 412
ILE A 420
ALA A 419
 GOL  A   4 ( 4.8A)
None
None
None
None
 0.97A 2gj5A-3krmA:
undetectable		 2gj5A-3krmA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3krm INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 5 LEU A 513
ALA A 519
ILE A 539
SER A 546
 None
 1.15A 2othA-3krmA:
undetectable		 2othA-3krmA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3krm INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 8 LEU A 513
VAL A 521
VAL A 494
ILE A 492
 None
 0.78A 4l4cB-3krmA:
undetectable		 4l4cB-3krmA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 3krm INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1
(Homo
sapiens) 		3 / 3 PHE A 464
ARG A 551
GLN A 547
 None
 1.17A 6g1pB-3krmA:
undetectable		 6g1pB-3krmA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 3krm INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 12 GLY A 506
GLY A 507
VAL A 510
VAL A 523
GLY A 500
 None
 1.09A 6gneA-3krmA:
undetectable		 6gneA-3krmA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 3krm INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 12 GLY A 506
GLY A 507
VAL A 510
VAL A 523
GLY A 500
 None
 1.08A 6gneB-3krmA:
undetectable		 6gneB-3krmA:
16.38