SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3krs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		5 / 10 GLY A 211
VAL A 214
ALA A 183
ASN A 218
ILE A 228
 None
 1.07A 1likA-3krsA:
undetectable		 1likA-3krsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		4 / 5 GLY A 230
ILE A 223
VAL A 214
SER A 248
 None
 1.14A 1rs7A-3krsA:
undetectable		 1rs7A-3krsA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		4 / 6 GLY A 230
ILE A 223
VAL A 214
SER A 248
 None
 1.08A 1rs7B-3krsA:
undetectable		 1rs7B-3krsA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 238
LYS A 239
VAL A  39
VAL A 233
LEU A  20
 None
 1.50A 1sv5A-3krsA:
undetectable		 1sv5A-3krsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		5 / 12 LEU A 153
LEU A 149
ILE A 125
HIS A 187
LEU A 206
 None
 1.13A 1tw4A-3krsA:
undetectable		 1tw4A-3krsA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		5 / 12 LEU A 153
LEU A 149
ILE A 125
HIS A 187
ILE A 208
 None
 1.20A 1tw4B-3krsA:
undetectable		 1tw4B-3krsA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		5 / 12 PHE A  53
SER A  26
ILE A  24
PHE A 242
ALA A 243
 None
 1.19A 2j0dA-3krsA:
undetectable		 2j0dA-3krsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		4 / 6 ILE A 209
ARG A 207
LEU A 206
LEU A 162
 None
 0.90A 3kp6A-3krsA:
undetectable
3kp6B-3krsA:
undetectable		 3kp6A-3krsA:
19.71
3kp6B-3krsA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		4 / 7 ILE A 228
LEU A 222
HIS A 187
SER A  98
 None
 0.83A 3r9vA-3krsA:
undetectable
3r9vB-3krsA:
undetectable		 3r9vA-3krsA:
24.37
3r9vB-3krsA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		5 / 12 PHE A  61
GLY A   9
GLY A   8
PHE A  11
ALA A 236
 None
 1.06A 4a6dA-3krsA:
undetectable		 4a6dA-3krsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		5 / 12 PHE A  61
GLY A   9
GLY A   8
PHE A  11
ALA A 236
 None
 1.09A 4a6eA-3krsA:
undetectable		 4a6eA-3krsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		5 / 9 LEU A 238
LYS A 239
VAL A  39
GLY A   9
LEU A  20
 None
 1.35A 4b3oA-3krsA:
undetectable		 4b3oA-3krsA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		5 / 12 VAL A 233
PHE A 231
GLY A   8
VAL A  37
PRO A 216
 None
 1.35A 4bvaA-3krsA:
undetectable		 4bvaA-3krsA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		5 / 12 VAL A 233
PHE A 231
GLY A   8
VAL A  37
PRO A 216
 None
 1.39A 4bvaB-3krsA:
undetectable		 4bvaB-3krsA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		4 / 5 GLY A 230
ILE A 223
VAL A 214
SER A 248
 None
 1.11A 4d33A-3krsA:
undetectable		 4d33A-3krsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		4 / 5 GLY A 230
ILE A 223
VAL A 214
SER A 248
 None
 1.07A 4d33B-3krsA:
undetectable		 4d33B-3krsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		4 / 6 GLY A 230
ILE A 223
VAL A 214
SER A 248
 None
 1.03A 4d39B-3krsA:
undetectable		 4d39B-3krsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		4 / 6 GLY A 230
ILE A 223
VAL A 214
SER A 248
 None
 1.10A 4kcnA-3krsA:
undetectable		 4kcnA-3krsA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		3 / 3 SER A  65
ASP A 158
ASP A  91
 None
 0.74A 4uckA-3krsA:
undetectable		 4uckA-3krsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		4 / 6 ARG A   3
ASP A 227
HIS A 187
ILE A 208
 None
 1.25A 5a06A-3krsA:
undetectable		 5a06A-3krsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 3krs TRIOSEPHOSPHATE
ISOMERASE
(Cryptosporidium
parvum) 		5 / 12 LEU A 232
GLY A   8
VAL A  37
PHE A  40
LEU A  94
 None
 1.27A 5jo9A-3krsA:
2.2		 5jo9A-3krsA:
22.61