SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3krt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		4 / 6 GLN A 403
ASP A 407
VAL A  82
HIS A 413
 None
 1.30A 1ekjG-3krtA:
undetectable
1ekjH-3krtA:
undetectable		 1ekjG-3krtA:
20.44
1ekjH-3krtA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 ASP A  61
GLY A 122
SER A 123
ALA A  33
ALA A 182
 None
 1.10A 1nw5A-3krtA:
undetectable		 1nw5A-3krtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		6 / 12 GLY A 122
GLY A 179
ILE A  34
ALA A  33
PHE A 174
SER A  86
 None
 1.27A 1ri4A-3krtA:
6.3		 1ri4A-3krtA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 SER A 393
LEU A 398
LEU A 181
ILE A  58
ALA A 404
 None
 1.07A 2bxcA-3krtA:
undetectable		 2bxcA-3krtA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		4 / 8 ARG A 221
GLY A 225
THR A 339
ILE A 366
 None
 0.92A 2f9wA-3krtA:
undetectable
2f9wB-3krtA:
undetectable		 2f9wA-3krtA:
22.73
2f9wB-3krtA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 PHE A 370
LEU A 209
VAL A 210
VAL A  82
LEU A 392
 None
 1.20A 2hc4A-3krtA:
undetectable		 2hc4A-3krtA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		3 / 3 ASP A  51
ARG A 410
ARG A  50
 None
 1.07A 2j9dA-3krtA:
undetectable
2j9dC-3krtA:
undetectable		 2j9dA-3krtA:
14.53
2j9dC-3krtA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		4 / 8 LEU A 392
PRO A 196
VAL A 430
GLY A 429
 None
 0.98A 2qd5A-3krtA:
undetectable		 2qd5A-3krtA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 11 ARG A 445
LEU A 218
ILE A 388
ALA A 251
ARG A 270
 None
 1.42A 2v0mA-3krtA:
undetectable		 2v0mA-3krtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		4 / 7 GLY A 122
ALA A 185
ALA A 182
VAL A 187
 None
 0.68A 3a2qA-3krtA:
undetectable		 3a2qA-3krtA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		4 / 7 GLU A 102
ASP A 115
SER A  96
THR A  41
 None
 0.99A 3dzgB-3krtA:
undetectable		 3dzgB-3krtA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.12A 3eeyA-3krtA:
5.5		 3eeyA-3krtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.13A 3eeyB-3krtA:
5.4		 3eeyB-3krtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.15A 3eeyC-3krtA:
5.6		 3eeyC-3krtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.16A 3eeyD-3krtA:
5.6		 3eeyD-3krtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.12A 3eeyE-3krtA:
5.0		 3eeyE-3krtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.13A 3eeyF-3krtA:
5.9		 3eeyF-3krtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.14A 3eeyH-3krtA:
5.6		 3eeyH-3krtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.14A 3eeyI-3krtA:
5.3		 3eeyI-3krtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.11A 3eeyJ-3krtA:
5.0		 3eeyJ-3krtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		3 / 3 HIS A 439
HIS A 198
ILE A 443
 None
 0.84A 3u52A-3krtA:
undetectable
3u52C-3krtA:
undetectable		 3u52A-3krtA:
21.82
3u52C-3krtA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 LEU A  74
ALA A  33
ILE A   8
CYH A 421
GLY A 127
 None
 1.23A 4hfpB-3krtA:
undetectable		 4hfpB-3krtA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 420
ALA A  79
GLU A 202
LEU A 428
ILE A  12
 None
 0.98A 4j24D-3krtA:
undetectable		 4j24D-3krtA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		4 / 8 TYR A 285
VAL A 333
ILE A 315
LEU A 309
 None
 0.84A 4jq1B-3krtA:
undetectable		 4jq1B-3krtA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		3 / 3 PRO A  64
VAL A 120
HIS A 119
 None
 0.76A 4pevC-3krtA:
undetectable		 4pevC-3krtA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 ALA A 404
LEU A 181
ILE A  58
THR A 401
GLY A 122
 None
 0.97A 4rzvA-3krtA:
undetectable		 4rzvA-3krtA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 11 THR A 246
ALA A 245
GLY A 253
GLY A 252
ALA A 251
 None
 1.01A 5lf3K-3krtA:
undetectable
5lf3L-3krtA:
undetectable		 5lf3K-3krtA:
17.69
5lf3L-3krtA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 11 THR A 246
ALA A 245
GLY A 253
GLY A 252
ALA A 251
 None
 1.01A 5lf3Y-3krtA:
undetectable
5lf3Z-3krtA:
undetectable		 5lf3Y-3krtA:
17.69
5lf3Z-3krtA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 VAL A 318
GLU A 320
SER A 330
PHE A 302
GLY A 236
 None
 1.28A 5ogcB-3krtA:
undetectable		 5ogcB-3krtA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 VAL A 408
GLY A 415
VAL A 417
ALA A 214
GLN A 217
 None
 1.19A 5x7fA-3krtA:
5.2		 5x7fA-3krtA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		4 / 5 VAL A 408
PRO A  54
GLY A 402
TYR A 406
 None
 1.08A 5x80A-3krtA:
undetectable
5x80B-3krtA:
undetectable		 5x80A-3krtA:
20.35
5x80B-3krtA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		4 / 5 PRO A  54
GLY A 402
TYR A 406
VAL A 408
 None
 1.09A 5x80C-3krtA:
undetectable
5x80D-3krtA:
undetectable		 5x80C-3krtA:
20.35
5x80D-3krtA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 PRO A 196
LEU A 199
VAL A 145
VAL A 146
LEU A 422
 None
 1.21A 6b52A-3krtA:
undetectable		 6b52A-3krtA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		3 / 3 ARG A 307
GLY A 312
GLU A 313
 None
 0.61A 6fgdA-3krtA:
undetectable		 6fgdA-3krtA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3krt CROTONYL COA
REDUCTASE
(Streptomyces
coelicolor) 		4 / 8 VAL A  65
TYR A  31
HIS A 114
TYR A 118
 None
None
CL  A 501 (-4.4A)
None
 1.30A 6gneB-3krtA:
2.7		 6gneB-3krtA:
22.00